SPDEF and STK11

Number of citations: 0 (PubMedID 16912160)
Data Source: BioGRID (two hybrid)

		SPDEF	STK11
Name		SAM pointed domain containing ETS transcription factor	serine/threonine kinase 11
Structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Cytoplasm Mitochondrion Centrosome Cytosol Cilium Membrane Extracellular Exosome Intracellular Protein-containing Complex Serine/threonine Protein Kinase Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Magnesium Ion Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity LRR Domain Binding Protein Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Glandular Epithelial Cell Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Cell Differentiation Positive Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Lung Goblet Cell Differentiation Intestinal Epithelial Cell Development Epithelial Cell Fate Commitment	Regulation Of Cell Growth Tissue Homeostasis Vasculature Development Protein Phosphorylation Protein Dephosphorylation Autophagy Apoptotic Process DNA Damage Response Signal Transduction Spermatogenesis Axonogenesis Negative Regulation Of Cell Population Proliferation Response To Ionizing Radiation Positive Regulation Of Autophagy Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Regulation Of Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Protein Localization To Nucleus Glucose Homeostasis Anoikis Positive Thymic T Cell Selection Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Golgi Localization Regulation Of Cell Cycle Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development G1 To G0 Transition Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Canonical Wnt Signaling Pathway Dendrite Extension Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Vesicle Transport Along Microtubule Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling
Pathways		None	AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes
Diseases		None	Peutz-Jeghers syndrome Pancreatic cancer
GWAS		Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Chronic lymphocytic leukemia (time to first treatment) ( 33510140 ) Height ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 27569725 ) Refractive error ( 32231278 ) Weight ( 28552196 )	Asthma (childhood onset) ( 31036433 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Distal/Left-sided colorectal cancer ( 33632709 ) Inflammatory bowel disease ( 28067908 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) PR interval ( 32439900 ) Psychosis in Alzheimer's disease ( 22005930 )
Interacting Genes		13 interacting genes: AR CDK11A CEP57 COX5A ENKD1 FAM161B NKX3-1 PCGF2 PSMA1 SNX20 SRPK2 STK11 TTC23	133 interacting genes: ABCB5 ADIPOR1 AKT1 ALDOB ANP32B APP ARAF ARG2 ARNT ATM AURKA BAP1 BCAS3 BECN1 BRAF CAB39 CALM2 CBLC CCDC180 CCND2 CCNE1 CD44 CDC14B CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFL2 CRY2 CTSB CYLC2 CYP17A1 D2HGDH DACH1 EEF1A2 EPHA2 ERBB2 ERLEC1 ETV4 FAIM2 FBP1 FBP2 FGFR4 FZR1 GLIS2 GNPDA1 GRM1 HERC2 HGF HIF1A HRAS IGFBP3 KAT2A KDELR2 KLK7 LATS2 LEF1 LYPD3 MAP2K1 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MAPK3 MAPRE1 MARK1 MARK2 MARK4 MET MOB4 MOCS2 MT-ND2 MYC NANS NAT2 NF2 PARD3 PDGFRA PDXP PHF23 PIK3CA PLD3 PPP2CB PRKAA2 PRKACA PRSS50 PTEN RASA1 RASSF1 RHOBTB2 RPS6KA3 RPS6KA5 RPS6KB1 S100A14 SEPTIN9 SIK1 SIRT1 SKP2 SMAD1 SMARCA4 SNRK SOX4 SPDEF ST14 STK11IP STK24 STRADA STRADB STX17 TBC1D23 TDRD7 TEAD2 TERT THOP1 THRSP TNFRSF1A TNIP2 TP53 TRIM25 TRMO TSG101 TUBA1A TUBB4A UBE2D2 VPS72 WT1 XPA YWHAG ZNF189 ZNF510
Entrez ID		25803	6794
HPRD ID		12176	03740
Ensembl ID		ENSG00000124664	ENSG00000118046
Uniprot IDs		O95238	A0A0S2Z4D1 Q15831
PDB IDs		1YO5 2DKX	2WTK 4ZDR 5WXN 8VSU
GO Terms Enriched among Interactors		Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Epithelial Cell Proliferation Regulation Of Reproductive Process Nuclear Receptor Activity Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Prostate Gland Growth Epithelial Cell Proliferation Involved In Prostate Gland Development Estrogen Response Element Binding Branching Involved In Prostate Gland Morphogenesis Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Nuclear Receptor-mediated Signaling Pathway Male Gonad Development Androgen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Estrogen Receptor Signaling Pathway Gonad Development Negative Regulation Of Epithelial Cell Proliferation Hormone-mediated Signaling Pathway Steroid Binding 14-3-3 Protein Binding Reproductive Structure Development Nuclear Estrogen Receptor Binding Developmental Process Involved In Reproduction Response To Testosterone Regulation Of Apoptotic Process Prostate Induction Regulation Of Programmed Cell Death Organ Growth Transcription Coactivator Binding Intracellular Receptor Signaling Pathway Male Somatic Sex Determination Positive Regulation Of Androgen Secretion MADS Box Domain Binding Regulation Of Morphogenesis Of A Branching Structure Cytoplasmic Microtubule Chromatin Response To Estrogen Regulation Of Morphogenesis Of An Epithelium Negative Regulation Of Reproductive Process Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Dorsal Aorta Development Centrosome Regulation Of MiRNA Transcription ATPase Binding Lipid Binding	Protein Kinase Activity Intracellular Signal Transduction Protein Serine Kinase Activity Kinase Activity Regulation Of Programmed Cell Death Protein Serine/threonine Kinase Activity Regulation Of Apoptotic Process Protein Kinase Binding Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Protein Phosphorylation Regulation Of Signal Transduction Cytoplasm Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Nucleotide Binding Signal Transduction Regulation Of Cell Population Proliferation Cellular Senescence Apoptotic Process Protein Modification Process Transferase Activity Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Signaling Cell Death Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Cell Cycle Process Intracellular Signaling Cassette Regulation Of Metabolic Process Developmental Process Protein Metabolic Process ATP Binding Regulation Of Protein Modification Process Regulation Of Macromolecule Metabolic Process MAPK Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Cellular Developmental Process Regulation Of Primary Metabolic Process Regulation Of Organelle Organization Positive Regulation Of Macromolecule Metabolic Process