NGEF and FAM118B

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		NGEF	FAM118B
Name		neuronal guanine nucleotide exchange factor	family with sequence similarity 118 member B
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Growth Cone Cell Projection Glutamatergic Synapse	Nucleus Cajal Body
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ephrin Receptor Binding	Protein Binding Identical Protein Binding
	Biological Process	Nervous System Development Cell Differentiation Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Synapse Pruning	None
Pathways		NRAGE signals death through JNK EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	None
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 31043756 ) Contrast sensitivity ( 24152035 ) Heel bone mineral density ( 28869591 30598549 ) Parkinson's disease ( 32201043 ) Pursuit maintenance gain ( 29064472 ) Schizophrenia ( 23974872 25056061 28991256 29483656 30285260 ) Sudden cardiac arrest ( 30169657 ) Superior temporal sulcus banks volume ( 31530798 )	No GWAS studies recorded
Interacting Genes		16 interacting genes: ATP5F1C C7orf25 C8orf33 EPHA4 FAM118B HCK LCOR MRPL44 NUDT21 RHOA SH2D1A SMO TAF1D TRIM55 TRIM63 USP7	29 interacting genes: BAG5 CEP126 CEP70 CTSB FAM118A FAM20C GNB2 ING5 ITFG1 MCM3AP MED31 NGEF PDCD10 PIAS2 QARS1 RAD54L2 RASGRP2 RBM48 SDCBP SEMA5B SETDB1 SHC1 SPRED1 SUMO1 SUMO1P1 TMSB4X VIM ZNF235 ZNF746
Entrez ID		25791	79607
HPRD ID		10442	07952
Ensembl ID		ENSG00000066248	ENSG00000197798
Uniprot IDs		B4DDI2 Q8N5V2	J3KP39 Q9BPY3
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Protein Sumoylation PML Body Organization