GABRA3 and UGT2B7

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		GABRA3	UGT2B7
Name		gamma-aminobutyric acid type A receptor subunit alpha3	UDP glucuronosyltransferase family 2 member B7
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Membrane Chloride Channel Complex Synapse Postsynaptic Membrane Postsynapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Binding Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Retinoic Acid Binding UDP-glycosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity
	Biological Process	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport Inhibitory Synapse Assembly	Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process
Pathways		GABA receptor activation GABA receptor activation	Glucuronidation Aspirin ADME Prednisone ADME
Drugs		Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Butalbital Phenytoin Etomidate Talbutal Talbutal Pentobarbital Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Meprobamate Carisoprodol Eszopiclone Eszopiclone Alprazolam Alprazolam Secobarbital Zolpidem Metharbital Metharbital Chlordiazepoxide Chlordiazepoxide Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Thiopental Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Midazolam Midazolam Flurazepam Flurazepam Isoflurane Primidone Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Methylphenobarbital Triazolam Triazolam Ethanol Zonisamide Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Halothane Desflurane Zopiclone Flumazenil Estazolam Estazolam Sevoflurane Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Glutethimide Barbital Camazepam Camazepam Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Pagoclone Ganaxolone Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam 1,2-Benzodiazepine 1,2-Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2′-trihydroxy-6,8-dimethoxyflavone AZD-7325 Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam	None
GWAS		No GWAS studies recorded	AR-C124910XX levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875 ) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 ) Estradiol levels ( 34255042 ) Gamma glutamyl transferase levels ( 33339817 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Obesity-related traits ( 23251661 ) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102 ) Urinary metabolite levels in chronic kidney disease ( 31959995 )
Interacting Genes		3 interacting genes: SDCBP2 UBQLN1 UGT2B7	2 interacting genes: CYP3A4 GABRA3
Entrez ID		2556	7364
HPRD ID		02375	02508
Ensembl ID		ENSG00000011677	ENSG00000171234
Uniprot IDs		P34903	E9PBP8 P16662
PDB IDs		9CTP	2O6L
GO Terms Enriched among Interactors		Negative Regulation Of Store-operated Calcium Channel Activity	Vitamin D Biosynthetic Process Quinine 3-monooxygenase Activity Anandamide 8,9 Epoxidase Activity Calcitriol Biosynthetic Process From Calciol Vitamin D 24-hydroxylase Activity Anandamide 11,12 Epoxidase Activity Vitamin D Catabolic Process 1,8-cineole 2-exo-monooxygenase Activity Anandamide 14,15 Epoxidase Activity Alkaloid Catabolic Process Vitamin D3 25-hydroxylase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Caffeine Oxidase Activity Testosterone 6-beta-hydroxylase Activity Oxidative Demethylation Vitamin D3 Metabolic Process Retinoic Acid 4-hydroxylase Activity Monoterpenoid Metabolic Process Aflatoxin Metabolic Process Lipid Hydroxylation Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Alkaloid Metabolic Process Demethylation Benzodiazepine Receptor Activity Vitamin D Metabolic Process Steroid Hydroxylase Activity Toxin Metabolic Process GABA-gated Chloride Ion Channel Activity GABA-A Receptor Activity GABA-A Receptor Complex Retinoic Acid Metabolic Process Xenobiotic Catabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Vitamin Metabolic Process Oxygen Binding Androgen Metabolic Process Steroid Catabolic Process Gamma-aminobutyric Acid Signaling Pathway Inhibitory Synapse Assembly Steroid Binding Postsynaptic Specialization Membrane Dendrite Membrane Synaptic Transmission, GABAergic Estrogen Metabolic Process Extracellular Ligand-gated Monoatomic Ion Channel Activity Long-chain Fatty Acid Biosynthetic Process Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Secondary Metabolic Process Retinol Metabolic Process