ACKR1 and CCL7

Number of citations: 0 (PubMedID 13679391)
Data Source: HPRD (in vivo)

		ACKR1	CCL7
Name		atypical chemokine receptor 1 (Duffy blood group)	C-C motif chemokine ligand 7
Structure
GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Membrane Recycling Endosome	Extracellular Region Extracellular Space
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Chemokine Binding C-C Chemokine Binding Signaling Receptor Activity	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CCR1 Chemokine Receptor Binding CCR2 Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Defense Response Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Chemokine-mediated Signaling Pathway	Monocyte Chemotaxis Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction Canonical NF-kappaB Signal Transduction Cell-cell Signaling Regulation Of Cell Shape Response To Gamma Radiation Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cell Migration Eosinophil Chemotaxis Positive Regulation Of Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Ethanol Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Peptide ligand-binding receptors	Chemokine receptors bind chemokines
GWAS		Eotaxin levels ( 27989323 ) Growth-regulated protein alpha levels ( 27989323 ) Midgestational total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095 ) Monocyte chemoattractant protein-1 levels ( 27989323 31217265 ) Neutrophil level response to clozapine in treatment-resistant schizophrenia ( 30647433 )	Blood protein levels ( 30072576 ) Crohn's disease ( 21102463 22412388 28067908 ) Gut microbiota (functional units) ( 27694959 ) Inflammatory bowel disease ( 28067908 )
Interacting Genes		9 interacting genes: CCL17 CCL2 CCL5 CCL7 CCL8 CXCL1 CXCL5 CXCL8 MTNR1B	18 interacting genes: ACKR1 ACKR2 ACKR4 CCR1 CCR10 CCR3 CCR5 CXCL6 FEZ1 MMP1 MMP13 MMP14 MMP2 MMP3 TLE5 UBQLN1 UBQLN2 XCL2
Entrez ID		2532	6354
HPRD ID		00192	01150
Ensembl ID		ENSG00000213088	ENSG00000108688
Uniprot IDs		Q16570 Q5Y7A1 Q5Y7A2	P80098
PDB IDs		4NUU 4NUV 7P93 8A44 8JPS	1BO0 1NCV 4ZKC 7S58 7S59 7SCU 8FJ3 8FK6 8FK8 8JPS
GO Terms Enriched among Interactors		Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Humoral Immune Response Chemotaxis Locomotion Granulocyte Chemotaxis Granulocyte Migration Myeloid Leukocyte Migration Inflammatory Response Leukocyte Chemotaxis Eosinophil Chemotaxis Immune Response Eosinophil Migration Defense Response To Symbiont Defense Response To Other Organism Defense Response CCR Chemokine Receptor Binding Leukocyte Migration Cell Migration Cell Motility Positive Regulation Of Leukocyte Migration Response To Other Organism Immune System Process Response To External Biotic Stimulus G Protein-coupled Receptor Signaling Pathway Extracellular Region Regulation Of Leukocyte Migration Chemokine-mediated Signaling Pathway Extracellular Space Positive Regulation Of Leukocyte Chemotaxis Monocyte Chemotaxis Regulation Of Lymphocyte Chemotaxis Cell-cell Signaling Signaling Killing Of Cells Of Another Organism Cellular Response To Fibroblast Growth Factor Stimulus Cell Communication Signal Transduction Positive Regulation Of Chemotaxis Response To Fibroblast Growth Factor CCR2 Chemokine Receptor Binding Response To Stress Cell Killing Cellular Response To Interleukin-1 Regulation Of Granulocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Chemotaxis	Chemokine-mediated Signaling Pathway C-C Chemokine Binding Chemokine Receptor Activity C-C Chemokine Receptor Activity Cell Chemotaxis Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Collagen Catabolic Process Extracellular Matrix Disassembly Collagen Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Migration Cell Surface Receptor Signaling Pathway Calcium-mediated Signaling Endopeptidase Activity Metalloendopeptidase Activity Cell Motility G Protein-coupled Receptor Signaling Pathway Cellular Response To UV-A G Protein-coupled Receptor Activity Metallopeptidase Activity Response To UV-A Serine-type Endopeptidase Activity Chemokine (C-C Motif) Ligand 5 Binding Inflammatory Response Immune System Process External Side Of Plasma Membrane Immune Response Response To Stress Extracellular Structure Organization Extracellular Matrix Organization Leukocyte Chemotaxis Chemokine Binding Intracellular Signaling Cassette Response To Amyloid-beta Defense Response Extracellular Matrix Leukocyte Migration Peptidase Activity Cellular Response To UV Signal Transduction Dendritic Cell Chemotaxis Positive Regulation Of ERAD Pathway Mononuclear Cell Migration Proteolysis Cellular Response To Light Stimulus Plasma Membrane Response To Cytokine Dendritic Cell Migration