NR5A2 and NPPA

Number of citations: 0 (PubMedID 15604093)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		NR5A2	NPPA
Name		nuclear receptor subfamily 5 group A member 2	natriuretic peptide A
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm RNA Polymerase II Transcription Regulator Complex	Extracellular Region Extracellular Space Cytoplasm Brush Border Protein-containing Complex Mast Cell Granule Cell Projection Perikaryon Perinuclear Region Of Cytoplasm Glycinergic Synapse
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Guanylate Cyclase Activator Activity Hormone Receptor Binding Neuropeptide Receptor Binding
	Biological Process	Primary Ovarian Follicle Growth Inner Cell Mass Cell Differentiation Positive Regulation Of T Cell Anergy Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Bile Acid Metabolic Process Hormone-mediated Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Tissue Development Neurogenesis Intracellular Receptor Signaling Pathway Exocrine Pancreas Development Positive Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Chondrocyte Differentiation Somatic Stem Cell Population Maintenance Embryonic Cleavage Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Homeostatic Process Cholesterol Homeostasis Positive Regulation Of Viral Genome Replication Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of T Cell Activation Cartilage Development Sertoli Cell Development Pancreas Morphogenesis Acinar Cell Differentiation Calcineurin-mediated Signaling Morula Formation Zygotic Genome Activation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Tendon Cell Differentiation	Response To Hypoxia System Process Negative Regulation Of Systemic Arterial Blood Pressure Cardiac Conduction System Development Aortic Valve Morphogenesis CGMP Biosynthetic Process Protein Folding Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Regulation Of Blood Pressure Positive Regulation Of Heart Rate Positive Regulation Of CGMP-mediated Signaling Cardiac Muscle Hypertrophy In Response To Stress CGMP-mediated Signaling Negative Regulation Of Cell Growth Response To Insulin Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Regulation Of Vascular Permeability Negative Regulation Of JUN Kinase Activity Negative Regulation Of Blood Pressure Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Blood Vessel Diameter Maintenance Synaptic Signaling Via Neuropeptide Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Collecting Lymphatic Vessel Constriction Cellular Response To Angiotensin Response To 3-methylcholanthrene
Pathways		Estrogen-dependent gene expression	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Amyloid fiber formation
Diseases		None	Atrial fibrillation
GWAS		Age at voice drop ( 27182965 ) Cerebrospinal T-tau levels ( 28247064 ) Cervical high-risk human papilloma virus infection (persistent) ( 33225922 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) FEV1 ( 30804560 ) Gamma glutamyl transferase levels ( 29403010 33339817 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hepcidin/transferrin saturation ratio ( 27846281 ) Hyperinsulinemia in obesity ( 30327367 ) Hyperinsulinemia x BMI interaction ( 30327367 ) Inflammatory bowel disease ( 28067908 ) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) Length of menstrual cycle ( 30202859 ) Lung adenocarcinoma ( 28604730 ) Lung function (FVC) ( 30804560 30061609 ) Menarche (age at onset) ( 25231870 ) Myopia ( 27182965 ) Nicotine dependence ( 28440896 ) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600 ) Pancreatic cancer ( 29422604 20101243 25086665 27579533 26098869 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 25014791 ) Ulcerative colitis ( 28067908 ) Uric acid levels ( 21294900 ) Urinary albumin excretion ( 30220432 )	Atrial fibrillation ( 19597492 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Midregional pro atrial natriuretic peptide levels ( 29237677 ) Psoriasis ( 25854761 ) Pulse pressure ( 30578418 ) Systolic blood pressure ( 19430483 30578418 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Tuberculosis ( 29036319 )
Interacting Genes		24 interacting genes: ALB BCKDK CTNNB1 DDB2 EDF1 FTH1 GTF2H2C HSP90B1 NCOA1 NCOA3 NPPA NR0B2 NR1I2 NRIP1 NSD1 PNRC1 PNRC2 POLR2D PROX1 RAD54L2 RANBP2 SMARCD3 SREBF1 UBE2I	14 interacting genes: EPB41 ESR1 HNF4A HSF2BP MAGEA12 MME NPR1 NPR2 NPR3 NR5A2 RORB UBQLN1 UBQLN2 UBQLN4
Entrez ID		2494	4878
HPRD ID		06830	00164
Ensembl ID		ENSG00000116833	ENSG00000175206
Uniprot IDs		F1D8R9 O00482	P01160
PDB IDs		1YOK 1YUC 1ZDU 2A66 3PLZ 3TX7 4DOR 4DOS 4IS8 4ONI 4PLD 4PLE 4RWV 5L0M 5L11 5SYZ 5UNJ 6OQX 6OQY 6OR1 6VC2 6VIF 7JYD 7JYE 7TT8 8F8M 8PKI	1ANP 1YK0 3N57 7BRH 7BRJ 7BRK 8TG9 9BCQ
GO Terms Enriched among Interactors		Nuclear Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Retinoic Acid Receptor Binding Nucleus Nuclear Estrogen Receptor Binding Transcription Coregulator Binding Protein-containing Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Transcription Coregulator Activity Positive Regulation Of RNA Metabolic Process Transcription Coactivator Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Nuclear Thyroid Hormone Receptor Binding Acinar Cell Differentiation Regulation Of Metabolic Process SUMO Ligase Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Response To Estradiol Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Primary Metabolic Process Rhythmic Process Regulation Of Neuroblast Proliferation Negative Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Neuron Fate Determination Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Protein-containing Complex Binding Nucleobase-containing Compound Biosynthetic Process Lens Morphogenesis In Camera-type Eye Hypothalamus Development Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Macromolecule Metabolic Process SUMO Transferase Activity	Natriuretic Peptide Receptor Activity Nuclear Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Polyubiquitin Modification-dependent Protein Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Intracellular Receptor Signaling Pathway Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Autophagosome Rhythmic Process Nucleobase-containing Compound Biosynthetic Process Female Genitalia Development Positive Regulation Of ERAD Pathway Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine Ribonucleotide Biosynthetic Process Regulation Of ERAD Pathway Peptide Binding Ribose Phosphate Biosynthetic Process Protein-containing Complex Ovulation Cycle Process Sequence-specific DNA Binding Transcription Coregulator Binding Genitalia Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process Blood Circulation G Protein-coupled Peptide Receptor Activity Vacuole Organization Blood Vessel Remodeling Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Macroautophagy Nucleotide Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Developmental Process Involved In Reproduction Organ Growth Zygotic Genome Activation Regulation Of Ornithine Metabolic Process Neuropeptide Processing ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Negative Regulation Of Store-operated Calcium Channel Activity Purine-containing Compound Biosynthetic Process Regulation Of Hormone Levels