SSBP3 and NXT2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SSBP3	NXT2
Name		single stranded DNA binding protein 3	nuclear transport factor 2 like export factor 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear RNA Export Factor Complex Nuclear Pore Central Transport Channel Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Protein Binding	Protein Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Cell Population Proliferation Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Mesendoderm Development Head Development Head Morphogenesis Protein-containing Complex Assembly Positive Regulation Of Anterior Head Development	MRNA Export From Nucleus Nucleocytoplasmic Transport Protein Transport Poly(A)+ MRNA Export From Nucleus MRNA Transport
GWAS		Adult body size ( 32376654 ) Blood urea nitrogen levels ( 29403010 31152163 ) Body mass index ( 25673413 ) Body size at age 10 ( 32376654 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) Food allergy ( 25710614 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Menarche (age at onset) ( 27182965 ) Monocyte count ( 32888494 ) P wave duration ( 28794112 ) Platelet distribution width ( 32888494 27863252 ) PR interval ( 32439900 ) Refractive error ( 32231278 ) Serum bilirubin levels in metabolic syndrome ( 30621171 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) T wave morphology restitution during recovery from exercise ( 31607149 ) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149 ) TPE interval (resting) ( 32386560 ) Triglyceride levels ( 32203549 32154731 )	No GWAS studies recorded
Interacting Genes		20 interacting genes: ANKEF1 APP ARNT2 BLK CLK1 DTNB EWSR1 HCLS1 IL36RN LDB1 LDB2 NXT2 PIN1 RFC1 SIVA1 SS18L1 SUPT5H TBC1D23 YES1 ZNF226	24 interacting genes: APP CCDC102B CEP63 DDIT4L GOLGA2 GOLGA6L9 IKZF3 LNX1 NXF1 NXF2 NXF2B NXF3 PKM PTPN3 RASSF10 REL SRPK1 SRPK2 SSBP3 STAT3 TCF4 TRIM23 USP54 ZNF655
Entrez ID		23648	55916
HPRD ID		09578	02264
Ensembl ID		ENSG00000157216	ENSG00000101888
Uniprot IDs		Q9BWW4 Q9NW25	Q9NPJ8
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process LIM Domain Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Enzyme Binding Negative Regulation Of Transcription By RNA Polymerase II Antifungal Humoral Response Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein Tyrosine Kinase Activity Transcription Coregulator Activity Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Protein Localization To Nucleus Epithelial Structure Maintenance Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Dendrite Development Cis-trans Isomerase Activity Hair Follicle Development CD27 Receptor Binding Regulation Of Metabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Defense Response To Fungus Acetylcholine Receptor Activator Activity Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Fungus Lipoprotein Particle	Nuclear RNA Export Factor Complex Poly(A)+ MRNA Export From Nucleus MRNA Export From Nucleus RNA Export From Nucleus Cytoplasm Nuclear Transport Nucleocytoplasmic Transport MRNA Transport Nuclear Export RNA Transport Intracellular Transport Nucleobase-containing Compound Transport Innate Immune Response Defense Response To Symbiont Protein Serine/threonine Kinase Binding Defense Response To Other Organism Response To Other Organism Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Localization Establishment Of Localization In Cell RNA Binding Positive Regulation Of Viral Genome Replication Amyloid-beta Complex Immune Response Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Spindle Pole Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation