SSBP2 and IL36RN

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (two hybrid, affinity chromatography technology), HPRD (two hybrid)

		SSBP2	IL36RN
Name		single stranded DNA binding protein 2	interleukin 36 receptor antagonist
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	DNA Binding Single-stranded DNA Binding Protein Binding	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Cytokine-mediated Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Antifungal Humoral Response Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Innate Immune Response Cellular Response To Lipopolysaccharide
Pathways		None	Interleukin-36 pathway
GWAS		Adult body size ( 32376654 ) Anorexia nervosa ( 21079607 ) Bipolar disorder ( 31043756 33263727 34002096 ) Glioblastoma ( 22472174 ) HDL cholesterol levels in HIV infection ( 33109212 ) Plateletcrit ( 32888494 )	Menstruation quality of life impact (dysmenorrhea) ( 29855537 ) Pain medicine use during menstruation ( 29855537 ) Stroke ( 26089329 )
Interacting Genes		7 interacting genes: CDK6 EWSR1 IL36RN LDB1 LDB2 PIN1 TOM1	18 interacting genes: AGR2 AP3M1 CNOT4 CRACR2B DDIT4L HPCA INCA1 IRAK4 MCM6 REL SH2B2 SKIL SSBP2 SSBP3 SSBP4 UBL4B ZKSCAN4 ZNF512B
Entrez ID		23635	26525
HPRD ID		09577	16112
Ensembl ID		ENSG00000145687	ENSG00000136695
Uniprot IDs		A0A087X159 P81877	Q9UBH0
PDB IDs		6IWV 6TYD 8HIB	4P0J 4P0K 4P0L
GO Terms Enriched among Interactors		LIM Domain Binding Transcription Coregulator Activity Regulation Of Metabolic Process Epithelial Structure Maintenance Negative Regulation Of Metabolic Process Regulation Of Erythrocyte Differentiation Cyclin D2-CDK6 Complex Cis-trans Isomerase Activity Cell Leading Edge Hair Follicle Development Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Establishment Of Protein Localization To Mitochondrion Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Somatic Stem Cell Population Maintenance Hair Cycle Process Myosin VI Binding Negative Regulation Of Biosynthetic Process	Single-stranded DNA Binding