PIK3R5 and SDHB

Number of citations: 0 (PubMedID 18624398)
Data Source: BioGRID (two hybrid)

		PIK3R5	SDHB
Name		phosphoinositide-3-kinase regulatory subunit 5	succinate dehydrogenase complex iron sulfur subunit B
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Complex, Class IB Membrane Centriolar Satellite	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex II (succinate Dehydrogenase)
	Molecular Function	G-protein Beta/gamma-subunit Complex Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Protein Binding Succinate Dehydrogenase (quinone) Activity Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Ubiquinone Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Tricarboxylic Acid Cycle Succinate Metabolic Process Mitochondrial Electron Transport, Succinate To Ubiquinone Aerobic Respiration Respiratory Electron Transport Chain Proton Motive Force-driven Mitochondrial ATP Synthesis
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Co-stimulation by ICOS	Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle
Drugs		None	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1
GWAS		Atypical femoral fracture in phosphonate treatment ( 31006051 ) Autoimmune thyroid disease ( 32581359 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Monocyte percentage of white cells ( 32888494 )	A body shape index ( 34021172 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Height ( 20189936 ) Hip circumference adjusted for BMI ( 34021172 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		5 interacting genes: APP CFTR PIK3CG SDHB SNX9	8 interacting genes: ABCA1 CARTPT GEM MSRA PIK3R5 SPRY2 TMEM132D XRN1
Entrez ID		23533	6390
HPRD ID		11433	01707
Ensembl ID		ENSG00000141506	ENSG00000117118
Uniprot IDs		J3KSW1 L7RT34 Q8WYR1	A0AAQ5BHD9 P21912
PDB IDs		Not available	7KCL 7KCM 7KLU 7KLV 8GS8
GO Terms Enriched among Interactors		Cellular Response To CAMP Response To CAMP Response To Purine-containing Compound Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Blood Circulation Regulation Of Membrane Protein Ectodomain Proteolysis Ephrin Receptor Binding Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Phosphate Metabolic Process Regulation Of Monoatomic Ion Transport Endocytosis Clathrin-coated Pit Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein-folding Chaperone Binding Regulation Of Phosphorus Metabolic Process Regulation Of Transport Import Into Cell Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Recycling Endosome Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Natural Killer Cell Chemotaxis Succinate Dehydrogenase (quinone) Activity 3 Iron, 4 Sulfur Cluster Binding Lipid Tube Assembly Positive Regulation Of Inflammatory Response	Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction