CBX6 and PCGF2

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)

		CBX6	PCGF2
Name		chromobox 6	polycomb group ring finger 2
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Nuclear Body PcG Protein Complex PRC1 Complex	Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	Chromatin Binding Single-stranded RNA Binding Protein Binding	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Organization Chromatin Remodeling Anterior/posterior Pattern Specification Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Oxidative Stress Induced Senescence RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional Regulation by E2F6
GWAS		Bladder cancer ( 20972438 24163127 ) Plateletcrit ( 32888494 )	No GWAS studies recorded
Interacting Genes		7 interacting genes: H3-3A H3C1 H3C14 HOXC9 PCGF2 PCGF6 RNF2	26 interacting genes: ABHD6 AKT1 CBX6 CCND2 CD247 CDK2 CTNNAL1 GJB5 HOXC9 HSF2 LMNA OGT PELI2 RBCK1 RNF2 SPDEF STX2 SUMO3 TRAF2 UBE2D3 UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7
Entrez ID		23466	7703
HPRD ID		13005	10621
Ensembl ID		ENSG00000183741	ENSG00000277258
Uniprot IDs		B0QXZ6 O95503	P35227
PDB IDs		3GV6 3I90	Not available
GO Terms Enriched among Interactors		Chromatin Remodeling PRC1 Complex Chromatin Organization PcG Protein Complex Sex Chromatin Structural Constituent Of Chromatin Nucleosome Assembly Nucleosome Nucleosome Organization Nucleoplasm Protein-DNA Complex Assembly Chromosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Epigenetic Regulation Of Gene Expression Gene Expression Embryonic Skeletal System Development Protein Heterodimerization Activity Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Pattern Specification Process DNA Binding Chromatin Embryonic Skeletal System Morphogenesis Embryonic Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Nucleus Skeletal System Morphogenesis Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Telomere Organization Embryonic Organ Morphogenesis Negative Regulation Of Macromolecule Metabolic Process RING-like Zinc Finger Domain Binding Negative Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Condensation Histone H2AK119 Ubiquitin Ligase Activity Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Anterior/posterior Pattern Specification Pericentric Heterochromatin Formation Regulation Of Centromere Complex Assembly Skeletal System Development Germ Cell Development Barr Body	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein Modification Process Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Transferase Activity TORC1 Signaling Protein Metabolic Process Protein K6-linked Ubiquitination TOR Signaling Protein K48-linked Ubiquitination Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Protein Monoubiquitination Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Protein K29-linked Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Ubiquitin Protein Ligase Activity Protein K63-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Metabolic Process Regulation Of Protein Localization PRC1 Complex Positive Regulation Of Protein Localization To Cell Surface Ubiquitin-like Protein Transferase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Response To Nitric Oxide Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Cycle Phase Transition PcG Protein Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process