AP4E1 and AP4B1

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology), HPRD (two hybrid)

		AP4E1	AP4B1
Name		adaptor related protein complex 4 subunit epsilon 1	adaptor related protein complex 4 subunit beta 1
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Membrane Membrane Coat AP-4 Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane	Golgi Apparatus Trans-Golgi Network Cytosol Membrane Membrane Coat AP-4 Adaptor Complex Clathrin Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane Cytoplasmic Side Of Trans-Golgi Network Transport Vesicle Membrane
	Molecular Function	Protein Binding Cargo Adaptor Activity	Protein Binding Clathrin Binding
	Biological Process	Protein Targeting Intracellular Protein Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization	Protein Targeting Intracellular Protein Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Protein Localization To Somatodendritic Compartment
Pathways		Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Diseases		Cerebral palsy	Cerebral palsy
GWAS		Chloride levels ( 29403010 ) Creatinine levels ( 29403010 ) Glomerular filtration rate ( 29403010 ) Height ( 31562340 ) Keratoconus ( 33649486 ) Potassium levels ( 29403010 ) Response to fenofibrate (HDL cholesterol levels) ( 27002377 )	Alopecia areata ( 25608926 ) Breast cancer ( 23535729 ) Crohn's disease ( 28067908 ) Mean corpuscular volume ( 32888494 ) Obesity-related traits ( 23251661 ) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655 )
Interacting Genes		3 interacting genes: AP4B1 ARF1 MTNR1B	4 interacting genes: AP4E1 BUB1 BUB1B ZNF576
Entrez ID		23431	10717
HPRD ID		06258	06259
Ensembl ID		ENSG00000081014	ENSG00000134262
Uniprot IDs		B4DM48 Q9UPM8	A0AAQ5BGI8 B1ALD1 B1ALD3 B3KSJ4 B4DTG3 Q9Y6B7
PDB IDs		Not available	2MJ7
GO Terms Enriched among Interactors		Cleavage Furrow Ingression Mitotic Cleavage Furrow Ingression Cytoplasmic Side Of Trans-Golgi Network Transport Vesicle Membrane Protein Localization To Somatodendritic Compartment Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Cholate-CoA Ligase Activity Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep AP-4 Adaptor Complex Fatty Acid Transmembrane Transporter Activity Very Long-chain Fatty Acid Catabolic Process Methyl-branched Fatty Acid Metabolic Process Fatty Acid Alpha-oxidation Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Long-chain Fatty Acid Import Into Cell Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Clathrin Adaptor Complex Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Intracellular Copper Ion Homeostasis Long-term Synaptic Depression Negative Regulation Of Cytosolic Calcium Ion Concentration Long-chain Fatty Acid Transmembrane Transporter Activity Long-chain Fatty Acid-CoA Ligase Activity Lipid Import Into Cell Regulation Of Transmission Of Nerve Impulse Copper Ion Homeostasis Negative Regulation Of Nervous System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm Regulation Of Circadian Sleep/wake Cycle Endosome Lumen Bile Acid Biosynthetic Process Intracellular Protein Transport Mitotic Cytokinetic Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Behavior Membrane Coat Dendritic Spine Organization Bile Acid Metabolic Process Regulation Of Actin Nucleation	Meiotic Sister Chromatid Cohesion, Centromeric Meiotic Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Outer Kinetochore Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Cohesion Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Segregation Regulation Of Nuclear Division Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition Kinetochore Mitotic Checkpoint Complex Kidney Development AP-4 Adaptor Complex Cargo Adaptor Activity Regulation Of Centromeric Sister Chromatid Cohesion Positive Regulation Of Sarcomere Organization Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Receptor Serine/threonine Kinase Binding Negative Regulation Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Atrial Cardiac Muscle Tissue Morphogenesis Telethonin Binding Negative Regulation Of Cell Cycle Phase Transition Metaphase/anaphase Transition Of Cell Cycle Regulation Of Sarcomere Organization Regulation Of Chromosome Organization Positive Regulation Of Sister Chromatid Cohesion Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cell Cycle Process Adult Heart Development Heart Trabecula Formation Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Regulation Of Organelle Organization Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Regulation Of Sister Chromatid Cohesion Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Cardiac Muscle Hypertrophy In Response To Stress