FNTB and CENPF

Number of citations: 0 (PubMedID 10852915)
Data Source: HPRD (in vitro)

		FNTB	CENPF
Name		farnesyltransferase, CAAX box, subunit beta	centromere protein F
Structure			No pdb structure
GO Annotations	Cellular Component	Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex	Chromosome, Centromeric Region Kinetochore Chromatin Spindle Pole Outer Kinetochore Nucleus Nuclear Envelope Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Axoneme Nuclear Matrix Midbody Ciliary Basal Body Pronucleus Perinuclear Region Of Cytoplasm Ciliary Transition Fiber
	Molecular Function	Catalytic Activity Prenyltransferase Activity Protein Farnesyltransferase Activity Protein Binding Zinc Ion Binding Protein Prenyltransferase Activity Acetyltransferase Activator Activity Transferase Activity Enzyme Binding Peptide Binding Metal Ion Binding	Chromatin Binding Protein Binding Microtubule Binding Protein Homodimerization Activity Dynein Complex Binding DNA-binding Transcription Factor Binding
	Biological Process	Lipid Metabolic Process Positive Regulation Of Cell Population Proliferation Protein Farnesylation Positive Regulation Of Cell Cycle Regulation Of Microtubule-based Movement	Mitotic Cell Cycle Kidney Development Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Muscle Organ Development Response To Xenobiotic Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Regulation Of Striated Muscle Tissue Development Ventricular System Development Cell Differentiation Negative Regulation Of DNA-templated Transcription Cell Division Metaphase Chromosome Alignment Kinetochore Assembly DNA Biosynthetic Process
Pathways		Inactivation, recovery and regulation of the phototransduction cascade RAS processing Potential therapeutics for SARS	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		AZD3409 Tipifarnib Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE	None
GWAS		Blood trace element (Zn levels) ( 23720494 ) Eosinophil count ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Mean corpuscular hemoglobin ( 27863252 32888494 28017375 ) Mean corpuscular hemoglobin concentration ( 32888494 27863252 29403010 ) Mean corpuscular volume ( 19862010 32888494 28017375 27863252 ) Mean platelet volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 23823483 ) Neutrophil count ( 32888494 ) Platelet count ( 27863252 32888494 ) Plateletcrit ( 32888494 ) Red blood cell count ( 27863252 32888494 ) Red blood cell traits ( 23222517 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325 ) Lung function (FVC) ( 30061609 ) Response to antineoplastic agents ( 21659360 ) Serum immune biomarker levels ( 32066700 )
Interacting Genes		17 interacting genes: AGXT APOL6 ATPAF2 CCDC24 CENPF FNTA GBP1 HDAC6 HOXC8 HRAS KRABD3 KRAS PTP4A3 RAP2A RRAS2 SMG9 TLX3	12 interacting genes: BRAP CDK1 CENPE CHMP2B FNTA FNTB KPNA1 NDEL1 NUP133 SNAP25 SVIL TOP3B
Entrez ID		2342	1063
HPRD ID		00608	02582
Ensembl ID		ENSG00000257365	ENSG00000117724
Uniprot IDs		A0A384MEJ5 P49356	A0A9L9PXU7 P49454
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37	Not available
GO Terms Enriched among Interactors		GDP Binding G Protein Activity GTPase Activity GTP Binding Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Dynein Complex Binding Regulation Of Long-term Neuronal Synaptic Plasticity Defense Response To Protozoan Regulation Of Rac Protein Signal Transduction Regulation Of Protein Localization To Membrane Microtubule Associated Complex Response To Protozoan Hydrolase Activity Protein-membrane Adaptor Activity Response To Mineralocorticoid L-serine-pyruvate Transaminase Activity Peptide Pheromone Maturation Alpha-tubulin Binding Hsp90 Protein Binding Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Glycine Biosynthetic Process, By Transamination Of Glyoxylate Oxalic Acid Secretion Microtubule Binding CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Regulation Of Microtubule-based Movement Protein Farnesyltransferase Activity Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Protein Farnesyltransferase Complex Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Cell Migration Glial Cell Development GTPase Complex Regulation Of Dendrite Morphogenesis Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Tubulin Deacetylase Activity Positive Regulation Of Cell Motility Positive Regulation Of Small GTPase Mediated Signal Transduction Glyoxylate Catabolic Process Alanine-glyoxylate Transaminase Activity Protein Farnesylation	Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Protein Farnesylation Microtubule Associated Complex Protein Prenyltransferase Activity Kinetochore Midbody Protein Prenylation Prenyltransferase Activity Acetyltransferase Activator Activity Chromosome Localization Nuclear Pore Nucleus Organization Kinetochore Microtubule Nuclear Localization Sequence Binding Nuclear Envelope Organization Microtubule Cytoskeleton Organization Involved In Mitosis Organelle Fusion Chromosome Organization Chromosome Segregation Cytosol Organelle Organization Pronuclear Fusion Chromosome, Centromeric Region Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Metaphase Chromosome Alignment Peptide Pheromone Maturation Alpha-tubulin Binding Cortisol Dehydrogenase (NADP+) Activity 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity 7-beta-hydroxysteroid Dehydrogenase (NADP+) Activity Glutamatergic Postsynaptic Density Negative Regulation Of Zinc Ion Transmembrane Import RNA Topoisomerase Activity Nuclear Membrane Organization Organelle Localization Regulation Of Microtubule-based Movement Regulation Of Cellular Localization Mitotic DNA-templated DNA Replication Spindle Cyclin B1-CDK1 Complex Regulation Of Protein Localization Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Metaphase Chromosome Alignment CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Hydroxylysine Biosynthetic Process Detoxification Of Zinc Ion