ZFPM2 and GATA3

Number of citations: 106 (PubMedID 35140242)
Data Source: BioGRID (proximity labelling technology), HPRD (two hybrid, in vitro)

		ZFPM2	GATA3
Name		zinc finger protein, FOG family member 2	GATA binding protein 3
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm	Chromatin Nucleus Nucleoplasm
	Molecular Function	DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Interleukin-2 Receptor Binding Protein Binding Zinc Ion Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding HMG Box Domain Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis In Utero Embryonic Development Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Right Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Transcription By RNA Polymerase II Gonadal Mesoderm Development Heart Development Cell Differentiation Lung Development Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Cell Fate Determination Neuron Migration Cell Activation Type IV Hypersensitivity Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Kidney Development Mesonephros Development Lens Development In Camera-type Eye Immune System Process Immune System Development Pro-T Cell Differentiation Aortic Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Septum Development Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Defense Response Inflammatory Response Humoral Immune Response Signal Transduction Nervous System Development Axon Guidance Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Xenobiotic Stimulus Response To Virus Anatomical Structure Morphogenesis Post-embryonic Development Positive Regulation Of Signal Transduction Response To Gamma Radiation Gene Expression Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Cell Differentiation Neuron Differentiation T Cell Differentiation Erythrocyte Differentiation Macrophage Differentiation Regulation Of Epithelial Cell Differentiation TOR Signaling Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production T Cell Differentiation In Thymus Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Embryonic Hemopoiesis Cellular Response To Interferon-alpha Ureter Maturation Parathyroid Hormone Secretion Norepinephrine Biosynthetic Process Inner Ear Morphogenesis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Neuron Apoptotic Process Ear Development Response To Estrogen Thymic T Cell Selection T-helper 2 Cell Differentiation Innate Immune Response Cell Fate Commitment Response To Ethanol Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of T-helper Cell Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Sympathetic Nervous System Development Thymus Development Embryonic Organ Development Developmental Growth Anatomical Structure Formation Involved In Morphogenesis System Development Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Regulation Of Developmental Process T Cell Receptor Signaling Pathway Cartilage Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Parathyroid Gland Development Pharyngeal System Development Uterus Development Canonical Wnt Signaling Pathway Mesenchymal To Epithelial Transition Mast Cell Differentiation Ureteric Bud Formation Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor Otic Vesicle Development Cellular Response To BMP Stimulus Positive Regulation Of Ureteric Bud Formation Nephric Duct Morphogenesis Nephric Duct Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Ureter Morphogenesis Lymphocyte Migration Cochlea Development Positive Regulation Of MiRNA Transcription Regulation Of Establishment Of Cell Polarity Negative Regulation Of Cell Motility Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Positive Regulation Of Thyroid Hormone Generation Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Cellular Response To X-ray Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation
Pathways		Transcriptional regulation of testis differentiation Factors involved in megakaryocyte development and platelet production	Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Formation of the nephric duct Factors involved in megakaryocyte development and platelet production Developmental Lineage of Mammary Stem Cells
Diseases		Tetralogy of Fallot	None
GWAS		Apolipoprotein A1 levels ( 32203549 ) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885 ) Basophil count ( 32888494 ) Birth weight ( 31043758 ) Brugada syndrome ( 35210625 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Coronary artery calcification ( 23870195 ) Coronary artery disease ( 29212778 33020668 ) Cytokine levels ( 31679650 ) Cytokine network levels (multivariate analysis) ( 31679650 ) Daytime nap ( 33568662 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Glaucoma (primary open-angle) ( 22570617 ) HDL cholesterol levels ( 32203549 ) HOMA-B (corrected for HOMA-IR) ( 30369944 ) Impulsivity (attentional) ( 30718321 ) Mean platelet volume ( 27863252 32888494 ) Metabolite levels ( 23823483 ) Monocyte count ( 32888494 ) Myocardial infarction ( 33532862 ) Neutrophil count ( 32888494 ) Platelet count ( 32888494 29403010 33545615 27863252 26805783 22139419 ) Platelet distribution width ( 32888494 27863252 ) Plateletcrit ( 27863252 32888494 ) PR interval ( 30046033 32439900 ) Red blood cell count ( 32888494 ) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552 ) Sudden cardiac arrest ( 21658281 ) Systolic blood pressure ( 28739976 ) Takayasu arteritis ( 25604533 ) Tuberculosis ( 24057671 ) Vascular endothelial growth factor levels ( 21757650 26910538 ) Venous thromboembolism ( 31676865 31420334 28373160 25772935 ) White blood cell count ( 32888494 ) White blood cell count (basophil) ( 27863252 )	Acute lymphoblastic leukemia (adolescents and young adults) ( 25468567 ) Acute lymphoblastic leukemia (B-cell precursor) ( 29296818 23996088 ) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011 ) Allergic rhinitis ( 31361310 30013184 ) Allergy ( 27182965 ) Asthma ( 34103634 29273806 27182965 30929738 32296059 31361310 31619474 31959851 ) Asthma (adult onset) ( 30929738 31036433 ) Asthma (childhood onset) ( 30929738 31036433 ) Asthma (moderate or severe) ( 30552067 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Autoimmune traits (pleiotropy) ( 30572963 ) B cell acute lymphoblastic leukaemia (abnormal cytogenetics) ( 29296818 ) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818 ) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818 ) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818 ) B cell acute lymphoblastic leukaemia in adulthood ( 29296818 ) B cell acute lymphoblastic leukaemia in young adulthood ( 29296818 ) B-cell acute lymphoblastic leukaemia ( 31767839 ) Basal cell carcinoma ( 25855136 27539887 ) Benign prostatic hyperplasia and/or lower urinary tract symptoms ( 28656603 ) Calcium levels ( 24068962 ) Colorectal cancer ( 30529582 28869801 25990418 24737748 31826910 ) Colorectal cancer (diet interaction) ( 24743840 ) Colorectal cancer or advanced adenoma ( 30510241 ) Craniofacial microsomia ( 26853712 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Fasting glucose change (short-term) ( 31263163 ) General risk tolerance (MTAG) ( 30643258 ) Glycemic traits (pleiotropy) ( 31021400 ) Hair shape ( 29220522 ) Hodgkin's lymphoma ( 29196614 24920014 21037568 ) Intracranial aneurysm ( 29531279 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mild influenza (H1N1) infection ( 26379185 ) Multiple sclerosis ( 31604244 ) Nasal polyps ( 30643255 ) Neutrophil percentage of white cells ( 32888494 ) Nodular sclerosis Hodgkin lymphoma ( 29196614 ) Obstetric antiphospholipid syndrome ( 28424481 ) Paclitaxel disposition in epithelial ovarian cancer ( 29367611 ) Plasma parathyroid hormone levels ( 30134803 ) Recalcitrant atopic dermatitis ( 25935106 ) Rheumatoid arthritis ( 23143596 30572963 24390342 30423114 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596 ) Scalp hair shape ( 26926045 ) Selective IgA deficiency ( 27723758 ) Self-reported allergy ( 23817569 ) Smoking status (ever vs never smokers) ( 30643258 ) Stroke ( 26089329 ) Systemic lupus erythematosus ( 26502338 ) Takayasu arteritis ( 25604533 ) Thyroid stimulating hormone levels ( 30367059 ) Type 1 diabetes ( 31152121 34012112 )
Interacting Genes		13 interacting genes: CTBP1 CTBP2 E2F6 EP300 FMR1 GATA1 GATA3 GATA4 IL32 ITSN1 PRPF3 STAT3 UBQLN4	33 interacting genes: ACTN2 CDK2 CYSRT1 ETS1 ETS2 FBXW7 HDAC2 HDAC3 HIF1A KDM1A KRTAP12-1 KRTAP13-2 KRTAP6-2 KRTAP6-3 LCK LMO1 LMO2 MAPK14 MED1 NFIA NFIB NFIC PLEKHG4 PSMA3 RARB REPIN1 SATB1 SP1 SPI1 TAL1 TRIM55 TRIM63 ZFPM2
Entrez ID		23414	2625
HPRD ID		04737	00572
Ensembl ID		ENSG00000169946	ENSG00000107485
Uniprot IDs		E7ET52 Q8WW38 Q9NPQ0	P23771
PDB IDs		Not available	4HC7 4HC9 4HCA
GO Terms Enriched among Interactors		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Coregulator Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Cell Fate Commitment Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Autophagy Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Male Gonad Development Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Gonad Development Negative Regulation Of Metabolic Process Transcription Coactivator Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Reproductive Structure Development Transcription Repressor Complex Identical Protein Binding Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Developmental Process Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Chromatin DNA Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction T-helper 17 Cell Lineage Commitment Transcription Cis-regulatory Region Binding Cardiac Right Ventricle Morphogenesis Nucleic Acid Metabolic Process Transcription By RNA Polymerase II Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA White Fat Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process T-helper Cell Lineage Commitment Chromatin Viral Genome Replication DNA-binding Transcription Factor Activity CD4-positive, Alpha-beta T Cell Lineage Commitment Fat Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulator Complex Platelet Formation Alpha-beta T Cell Lineage Commitment Embryonic Hemopoiesis	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Erythrocyte Differentiation Chromatin DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression DNA-binding Transcription Factor Activity Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Binding Regulation Of Myeloid Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Neural Precursor Cell Proliferation Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein De-2-hydroxyisobutyrylase Activity Positive Regulation Of Myeloid Cell Differentiation Regulation Of Cell Population Proliferation Regulation Of Hemopoiesis Regulation Of Macromolecule Metabolic Process Generation Of Neurons Positive Regulation Of Chromatin Organization Protein Lysine Delactylase Activity Sequence-specific DNA Binding Positive Regulation Of Blood Vessel Endothelial Cell Migration Embryonic Hemopoiesis Protein Binding Regulation Of Metabolic Process Nucleus