ZDHHC17 and HBG1

Number of citations: 111 (PubMedID 24705354)
Data Source: BioGRID (two hybrid)

		ZDHHC17	HBG1
Name		zDHHC palmitoyltransferase 17	hemoglobin subunit gamma 1
Structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse Perforant Pathway To Dendrate Granule Cell Synapse Postsynaptic Golgi Apparatus	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Protein-cysteine S-stearoyltransferase Activity	Oxygen Carrier Activity Oxygen Binding Heme Binding Hemoglobin Alpha Binding Metal Ion Binding
	Biological Process	Axonogenesis Protein Palmitoylation Lipoprotein Transport Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission	Carbon Dioxide Transport Oxygen Transport Erythrocyte Development
Pathways		None	Factors involved in megakaryocyte development and platelet production
GWAS		Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009 ) Metabolite levels ( 23823483 ) Visceral fat ( 30942860 )	Beta thalassemia/hemoglobin E disease ( 20183929 ) Hematology traits ( 23263863 ) Hemoglobin levels ( 26366553 ) Logical memory (delayed recall) in normal cognition ( 29274321 ) Logical memory (immediate recall) in normal cognition ( 29274321 ) Malaria ( 31844061 ) Mean corpuscular hemoglobin concentration ( 23263863 )
Interacting Genes		192 interacting genes: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCDC7 CCNE2 CDSN CENPBD2P CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DELE1 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM9A FBH1 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 H2AP H2BC9 H3C10 HBG1 HECTD3 HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT IFT20 IFT57 INPP5D JMJD7-PLA2G4B KHDC4 KIAA0408 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LCMT1P1 LGALS9C LIN28A LMAN2L LNCRI LRRC45 LY6G6C MANF MAP2K4 MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF ODF2 OFCC1 OTUD7B OTX2 PABIR3 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L RUBCNL SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SLX9 SMARCB1 SNAP25 SOX14 SP2 SPRY3 SPRY4 SREBF2 SRSF4 STK25 STN1 SUMF2 SYT1 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TUT7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VN1R10P VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9	5 interacting genes: APP KRTAP10-3 KRTAP10-9 TRIM54 ZDHHC17
Entrez ID		23390	3047
HPRD ID		09697	00789
Ensembl ID		ENSG00000186908	ENSG00000213934
Uniprot IDs		A8KA01 Q8IUH5	D9YZU8 P69891
PDB IDs		3EU9 5W7I 5W7J	1I3D 1I3E
GO Terms Enriched among Interactors		Protein Binding	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Regulation Of ERK1 And ERK2 Cascade Regulation Of Type II Interferon Production Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Type II Interferon Production Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Glial Cell Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of MAPK Cascade Phospholipase C Activator Activity GTPase Complex Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Keratin Filament Regulation Of JNK Cascade Axonogenesis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate Filament Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Defense Response To Other Organism Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Positive Regulation Of ERK1 And ERK2 Cascade Protein-cysteine S-myristoyltransferase Activity Regulation Of Spontaneous Synaptic Transmission