ZDHHC17 and CTCFL

Number of citations: 111 (PubMedID 24705354)
Data Source: BioGRID (two hybrid)

		ZDHHC17	CTCFL
Name		zDHHC palmitoyltransferase 17	CCCTC-binding factor like
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse Perforant Pathway To Dendrate Granule Cell Synapse Postsynaptic Golgi Apparatus	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body
	Molecular Function	Signaling Receptor Binding Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Protein-cysteine S-stearoyltransferase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Histone Binding Chromatin Insulator Sequence Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Axonogenesis Protein Palmitoylation Lipoprotein Transport Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Protein Localization To Chromosome Epigenetic Regulation Of Gene Expression Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Establishment Of Protein Localization To Chromatin Genomic Imprinting
GWAS		Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009 ) Metabolite levels ( 23823483 ) Visceral fat ( 30942860 )	Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Mean corpuscular hemoglobin ( 29403010 ) Mean corpuscular volume ( 29403010 ) Obesity-related traits ( 23251661 ) Prudent dietary pattern ( 28644415 ) Response to cytadine analogues (cytosine arabinoside) ( 24483146 ) Response to statin therapy ( 20339536 ) Triglyceride levels ( 32203549 ) Type 2 diabetes ( 23300278 )
Interacting Genes		192 interacting genes: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCDC7 CCNE2 CDSN CENPBD2P CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DELE1 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM9A FBH1 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 H2AP H2BC9 H3C10 HBG1 HECTD3 HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT IFT20 IFT57 INPP5D JMJD7-PLA2G4B KHDC4 KIAA0408 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LCMT1P1 LGALS9C LIN28A LMAN2L LNCRI LRRC45 LY6G6C MANF MAP2K4 MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF ODF2 OFCC1 OTUD7B OTX2 PABIR3 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L RUBCNL SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SLX9 SMARCB1 SNAP25 SOX14 SP2 SPRY3 SPRY4 SREBF2 SRSF4 STK25 STN1 SUMF2 SYT1 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TUT7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VN1R10P VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9	10 interacting genes: AURKA BAG6 BRCA1 H1-1 H2AC20 H3C1 PRMT7 SP1 TBP ZDHHC17
Entrez ID		23390	140690
HPRD ID		09697	09512
Ensembl ID		ENSG00000186908	ENSG00000124092
Uniprot IDs		A8KA01 Q8IUH5	A6XGM0 A6XGM9 Q8NI51 V9GY73 V9GYX4
PDB IDs		3EU9 5W7I 5W7J	Not available
GO Terms Enriched among Interactors		Protein Binding	Chromatin Organization Chromatin Remodeling Euchromatin Pronucleus Epigenetic Regulation Of Gene Expression Structural Constituent Of Chromatin Nucleosome Nucleoplasm Regulation Of Macromolecule Metabolic Process Protein-DNA Complex Assembly Transcription Cis-regulatory Region Binding Centrosome Cycle Regulation Of Centrosome Cycle DNA Binding Chromosome Regulation Of Metabolic Process Male Germ Cell Nucleus Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Perforant Pathway To Dendrate Granule Cell Synapse Ubiquitin Protein Ligase Binding Histone H2AK127 Ubiquitin Ligase Activity Nucleus Microtubule Organizing Center Organization Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Programmed Cell Death Cellular Component Assembly Chromosome Organization Response To Wortmannin Protein Heterodimerization Activity Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Protein Modification Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Oocyte Maturation BAT3 Complex Protein-arginine Omega-N Symmetric Methyltransferase Activity Nucleosome Assembly BRCA1-B Complex Regulation Of Cell Cycle G2/M Phase Transition Male Gamete Generation Spermatogenesis Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Positive Regulation Of Proteasomal Protein Catabolic Process Histone H3S10 Kinase Activity TFIIB-class Transcription Factor Binding