ZDHHC17 and ADD1

Number of citations: 111 (PubMedID 24705354)
Data Source: BioGRID (two hybrid)

		ZDHHC17	ADD1
Name		zDHHC palmitoyltransferase 17	adducin 1
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse Perforant Pathway To Dendrate Granule Cell Synapse Postsynaptic Golgi Apparatus	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion F-actin Capping Protein Complex Postsynaptic Density Membrane Nuclear Body Cell Junction
	Molecular Function	Signaling Receptor Binding Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Protein-cysteine S-stearoyltransferase Activity	RNA Binding Actin Binding Protein Binding Calmodulin Binding Cytoskeletal Anchor Activity Spectrin Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Protein Dimerization Activity Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Axonogenesis Protein Palmitoylation Lipoprotein Transport Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission	Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cellular Component Size Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Positive Regulation Of Developmental Process Positive Regulation Of Cellular Component Organization Cellular Response To Calcium Ion Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Adherens Junction Organization Regulation Of Multicellular Organismal Development
Pathways		None	Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Miscellaneous transport and binding events
GWAS		Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009 ) Metabolite levels ( 23823483 ) Visceral fat ( 30942860 )	Coffee consumption (cups per day) ( 31837886 ) Household income ( 31844048 ) Household income (MTAG) ( 31844048 ) Huntington's disease progression ( 28642124 ) Monocyte percentage of white cells ( 32888494 )
Interacting Genes		192 interacting genes: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCDC7 CCNE2 CDSN CENPBD2P CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DELE1 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM9A FBH1 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 H2AP H2BC9 H3C10 HBG1 HECTD3 HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT IFT20 IFT57 INPP5D JMJD7-PLA2G4B KHDC4 KIAA0408 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LCMT1P1 LGALS9C LIN28A LMAN2L LNCRI LRRC45 LY6G6C MANF MAP2K4 MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF ODF2 OFCC1 OTUD7B OTX2 PABIR3 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L RUBCNL SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SLX9 SMARCB1 SNAP25 SOX14 SP2 SPRY3 SPRY4 SREBF2 SRSF4 STK25 STN1 SUMF2 SYT1 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TUT7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VN1R10P VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9	24 interacting genes: ADD2 AIRIM ATP1A1 CALM1 CASP3 CDK1 CSNK2B GEMIN7 HMG20A HSF2BP HSPH1 ID2 ID3 KLHL42 MAP1LC3B PRKACA PRKCA PRKCD RFX1 ROCK1 SPTA1 SPTB TK1 ZDHHC17
Entrez ID		23390	118
HPRD ID		09697	00036
Ensembl ID		ENSG00000186908	ENSG00000087274
Uniprot IDs		A8KA01 Q8IUH5	A0A804HL01 P35611
PDB IDs		3EU9 5W7I 5W7J	Not available
GO Terms Enriched among Interactors		Protein Binding	Negative Regulation Of Actin Filament Polymerization Cytosol DNA Synthesis Involved In Mitotic DNA Replication Peptidyl-threonine Phosphorylation Protein Phosphorylation Actin Filament Capping Phosphorylation Kinase Activity Thymidine Biosynthetic Process Protein Serine/threonine Kinase Activity Regulation Of Angiotensin-activated Signaling Pathway Protein Kinase C Signaling Negative Regulation Of Actin Filament Depolymerization Regulation Of Muscle System Process Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Organization Negative Regulation Of Protein-containing Complex Assembly Thymidine Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Length Spectrin-associated Cytoskeleton Negative Regulation Of Cytoskeleton Organization Protein Kinase Activity Cytoplasm Negative Regulation Of Supramolecular Fiber Organization Spectrin Response To Reactive Oxygen Species ATP Binding Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Nucleocytoplasmic Transport Mitotic Nuclear Membrane Disassembly Regulation Of Actin Cytoskeleton Organization Protein Serine Kinase Activity Pyrimidine Nucleoside Metabolic Process Intracellular Signaling Cassette Regulation Of Actin Filament-based Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Supramolecular Fiber Organization Regulation Of Amide Metabolic Process Nuclear Membrane Disassembly Response To Hormone Cell Communication By Electrical Coupling Involved In Cardiac Conduction Membrane Disassembly Positive Regulation Of Macrophage Differentiation Regulation Of Cell Activation Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Depolymerization Protein Modification Process