NCSTN and APH1B

Number of citations: 0 (PubMedID 12857757)
Data Source: HPRD (in vitro, in vivo)

		NCSTN	APH1B
Name		nicastrin	aph-1B gamma-secretase subunit
Structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Focal Adhesion Synaptic Vesicle Endosome Membrane Endomembrane System Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Azurophil Granule Membrane Sarcolemma Melanosome Presynaptic Membrane Extracellular Exosome Gamma-secretase Complex Synaptic Membrane Secretory Vesicle	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Membrane Transport Vesicle Gamma-secretase Complex
	Molecular Function	Endopeptidase Activity Protein Binding Peptidase Activity Protein-macromolecule Adaptor Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving ATPase Binding Endopeptidase Activator Activity Growth Factor Receptor Binding	Protein Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity
	Biological Process	Myeloid Cell Homeostasis Proteolysis Membrane Protein Ectodomain Proteolysis G Protein-coupled Dopamine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Learning Or Memory Protein Processing Cerebellum Development Central Nervous System Myelination Adult Behavior Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation T Cell Proliferation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Amyloid Precursor Protein Catabolic Process Amyloid-beta Metabolic Process Epithelial Cell Proliferation Neuron Apoptotic Process Cellular Response To Calcium Ion Regulation Of Long-term Synaptic Potentiation Short-term Synaptic Potentiation	Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process
Pathways		Nuclear signaling by ERBB4 Degradation of the extracellular matrix Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells Neutrophil degranulation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation	Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation
Diseases		Acne inversa; Hidradenitis supprativa	None
GWAS		Post bronchodilator FEV1 in COPD ( 26634245 )	Alzheimer's disease or family history of Alzheimer's disease ( 30617256 ) Estimated glomerular filtration rate ( 31152163 ) Family history of Alzheimer's disease ( 30617256 ) Metabolite levels ( 23823483 ) Myopia ( 27182965 ) Refractive error ( 32231278 ) Response to fenofibrate (triglyceride levels) ( 27002377 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 )
Interacting Genes		11 interacting genes: ABL1 APH1A APH1B APP BACE1 MAPK9 PSEN1 PSEN2 PSENEN SPP1 TMED10	7 interacting genes: FXYD6-FXYD2 NCSTN PSEN1 PSEN2 TM4SF4 TRARG1 VSTM1
Entrez ID		23385	83464
HPRD ID		05584	06361
Ensembl ID		ENSG00000162736	ENSG00000138613
Uniprot IDs		A0A8V8TPQ8 A0A8V8TPR8 B4DR82 Q92542	Q8WW43
PDB IDs		2N7Q 2N7R 4UIS 5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X 7Y5T 7Y5X 7Y5Z 8IM7 8K8E 8KCO 8KCP 8KCS 8KCT 8KCU 8OQY 8OQZ 8X52 8X53 8X54	8OQY 8OQZ
GO Terms Enriched among Interactors		Gamma-secretase Complex Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Notch Receptor Processing Membrane Protein Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Protein Processing Protein Maturation Membrane Protein Intracellular Domain Proteolysis Synaptic Membrane Enzyme Binding Positive Regulation Of Proteolysis Endopeptidase Activator Activity Modulation Of Chemical Synaptic Transmission Golgi Apparatus Protein Metabolic Process Endoplasmic Reticulum Early Endosome Presynaptic Membrane Synaptic Vesicle Golgi Membrane Astrocyte Activation Involved In Immune Response Neuron Projection Organization Plasma Membrane Regulation Of Proteolysis Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Cellular Response To Amyloid-beta Negative Regulation Of Axonogenesis Aspartic Endopeptidase Activity, Intramembrane Cleaving Response To Amyloid-beta Cell Surface Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cytokine Production Cellular Response To Manganese Ion Positive Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Learning Or Memory Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Transport Neuron Projection Maintenance Endoplasmic Reticulum Membrane Endosome Membrane Signal Transduction	Gamma-secretase Complex Aspartic Endopeptidase Activity, Intramembrane Cleaving Notch Receptor Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Membrane Protein Proteolysis Growth Factor Receptor Binding Synaptic Membrane Notch Signaling Pathway Presynaptic Membrane Synaptic Vesicle Protein Processing Cerebellum Development Azurophil Granule Membrane Protein Maturation Early Endosome Negative Regulation Of Core Promoter Binding Amyloid Precursor Protein Biosynthetic Process ATPase Binding Endopeptidase Activity Myelination Axon Ensheathment Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Peptidase Activity Cajal-Retzius Cell Differentiation Neuron Apoptotic Process Sarcolemma Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Short-term Synaptic Potentiation Negative Regulation Of Transcription By RNA Polymerase III Positive Regulation Of L-glutamate Import Across Plasma Membrane Synaptic Vesicle Targeting Astrocyte Activation Involved In Immune Response Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Sequestering Of Calcium Ion Positive Regulation Of Amyloid Fibril Formation Kinetochore Golgi Membrane Regulation Of Calcium Import Into The Mitochondrion Cytoplasmic Vesicle Membrane Glucose Import In Response To Insulin Stimulus Epithelial Cell Proliferation Schwann Cell Differentiation Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Synaptic Plasticity Regulation Of L-glutamate Import Across Plasma Membrane