CRTC1 and CREB1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CRTC1	CREB1
Name		CREB regulated transcription coactivator 1	cAMP responsive element binding protein 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrial Matrix Centrosome Cytosol Axon Ciliary Basal Body RNA Polymerase II Transcription Regulator Complex ATF4-CREB1 Transcription Factor Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding CAMP Response Element Binding Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Hsp70 Protein Binding Histone Acetyltransferase Binding CAMP Response Element Binding Identical Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Arrestin Family Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Memory Positive Regulation Of CREB Transcription Factor Activity Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein Homotetramerization Cellular Response To CAMP Energy Homeostasis Negative Regulation Of Membrane Hyperpolarization	Response To Hypoxia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Axonogenesis Lactation Memory Circadian Rhythm Regulation Of Cell Size Visual Learning Response To Xenobiotic Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Transcription By Competitive Promoter Binding Response To Purine-containing Compound Response To Activity Pituitary Gland Development Cell Differentiation Osteoclast Differentiation Mammary Gland Development Positive Regulation Of Transforming Growth Factor Beta3 Production Secretory Granule Organization Response To Glucagon Chemotaxis To Arachidonate Response To Nicotine Cellular Response To Hepatocyte Growth Factor Stimulus Response To Erythropoietin Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Multicellular Organism Growth Response To Cocaine MRNA Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Response To Morphine Response To Ethanol Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Hormone Secretion Positive Regulation Of Hormone Secretion Positive Regulation Of Lipid Biosynthetic Process Regulation Of Fibroblast Proliferation Rhythmic Process Protein Stabilization Positive Regulation Of Cardiac Muscle Tissue Development Regulation Of Glial Cell Proliferation Lung Epithelium Development Lung Saccule Development Type I Pneumocyte Differentiation Cellular Response To Zinc Ion Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Cellular Response To Fatty Acid Cellular Response To Transforming Growth Factor Beta Stimulus CAMP/PKA Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation Response To L-glutamate Response To Dehydroepiandrosterone Positive Regulation Of Membrane Depolarization Cellular Response To Forskolin Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Leukemia Inhibitory Factor Response To Hypobaric Hypoxia Regulation Of Testosterone Biosynthetic Process
Pathways		Transcriptional activation of mitochondrial biogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	None
Drugs		None	Adenosine phosphate Naloxone
GWAS		Adult body size ( 32376654 ) Barrett's esophagus ( 24121790 ) Barrett's esophagus or Esophageal adenocarcinoma ( 32918910 27527254 ) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910 ) Body fat percentage ( 26833246 ) Body mass index ( 28448500 28552196 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index in physically active individuals ( 28448500 ) Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined) ( 24121790 ) Esophageal adenocarcinoma ( 24121790 ) Estimated glomerular filtration rate ( 31152163 ) Gastroesophageal reflux disease ( 31527586 34187846 ) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401 ) Menarche (age at onset) ( 21102462 25231870 ) Walking pace ( 33128006 )	Body mass index ( 25673413 28892062 ) Diastolic blood pressure ( 27841878 ) Food antigen IgG levels ( 24962563 ) Mean corpuscular hemoglobin ( 32888494 ) Refractive error ( 32231278 ) Systolic blood pressure ( 27841878 )
Interacting Genes		5 interacting genes: CREB1 MAP3K1 SRPK2 TBK1 YWHAG	86 interacting genes: ABL1 AGR2 AKT1 ATF1 ATF6 ATF7IP ATM ATR BRD10 CAMK2A CCDC6 CDK1 CEBPB CHD3 CHD8 CREBBP CREM CRTC1 CRTC2 CSNK1D CSNK2A1 CSNK2B DNMT3L DYRK1A EDF1 ERG28 ETS1 FHL5 GLI2 GSK3A GSK3B GTF2A1 GTF2F2 HIPK3 HIVEP1 HNF1B HPS6 KAT5 KCNIP3 MAPK14 MAPKAPK2 MTF2 NR3C1 PDX1 PIAS1 PIAS2 POGZ POU2F1 PPP1CA PRKACA PRKG1 PTEN RAB1A RBBP4 RECQL5 RFX3 RGS13 RNF111 RNF4 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 SGK1 SMARCA4 SMARCA5 SMCO1 SOX9 SRA1 SREBF2 SRF SUZ12 THRA TOX4 TRIM22 TSSK4 UBE2I VIM YY1 ZHX1 ZMYM2 ZNF35 ZNF436 ZNF451 ZNF92
Entrez ID		23373	1385
HPRD ID		06339	00442
Ensembl ID		ENSG00000105662	ENSG00000118260
Uniprot IDs		Q6UUV9	B7Z5C6 P16220 Q53X93 Q5U0J5
PDB IDs		7D8H 7D8P 7D9V	2LXT 5ZK1 5ZKO 7TBH
GO Terms Enriched among Interactors		Protein Modification Process Protein Phosphorylation Phosphorylation Protein Metabolic Process Intracellular Signal Transduction Intracellular Signaling Cassette Phosphoprotein Binding Peptidyl-serine Phosphorylation Positive Regulation Of Translational Initiation MRNA Transcription Signal Transduction Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression Chemotaxis To Arachidonate TOR Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Modulation Of Chemical Synaptic Transmission Phosphate-containing Compound Metabolic Process Macromolecule Metabolic Process Protein Kinase Activity Regulation Of TORC1 Signaling Regulation Of Translational Initiation Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Transforming Growth Factor Beta3 Production Cytoplasmic Translation MRNA Metabolic Process Kinase Activity Response To Dehydroepiandrosterone Regulation Of Immune System Process Response To Stress Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Protein Kinase C Inhibitor Activity Dendritic Cell Proliferation Positive Regulation Of Multicellular Organismal Process Regulation Of TOR Signaling Positive Regulation Of Translation ATF4-CREB1 Transcription Factor Complex Response To Hypobaric Hypoxia Trans-synaptic Signaling By BDNF Nuclear Speck Organization Cellular Response To Peptide Hormone Stimulus Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly	Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Serine/threonine Kinase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Serine Kinase Activity Protein Kinase Activity PML Body Kinase Activity Chromatin DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation ATP Binding Transferase Activity Chromatin Remodeling Phosphorylation Cellular Response To Oxygen-containing Compound Cellular Response To Stress Positive Regulation Of CREB Transcription Factor Activity DNA-binding Transcription Factor Activity Chromatin Organization Sequence-specific DNA Binding Nucleic Acid Metabolic Process Intracellular Signal Transduction