FNBP4 and SYNJ1

Number of citations: 0 (PubMedID 11292345)
Data Source: HPRD (in vitro)

		FNBP4	SYNJ1
Name		formin binding protein 4	synaptojanin 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Cytoplasm Cytosol Microtubule Vesicle Membrane Membrane Membrane Coat Clathrin Coat Of Coated Pit Terminal Bouton Perinuclear Region Of Cytoplasm Synaptic Membrane Presynapse
	Molecular Function	Protein Binding	Nucleic Acid Binding RNA Binding Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity
	Biological Process	None	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Neurotransmitter Transport Endocytosis Learning Synaptic Vesicle Priming Synaptic Vesicle Uncoating Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Membrane Organization Positive Regulation Of Endosome Organization
Pathways		None	Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Clathrin-mediated endocytosis
GWAS		Alcohol use disorder (consumption score) ( 30336701 ) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Appendicular lean mass ( 33097823 ) Body mass index ( 28892062 ) Brain morphology (MOSTest) ( 32665545 ) Free thyroxine concentration ( 30367059 ) Fruit consumption ( 32066663 ) Global electrical heterogeneity phenotypes ( 29622589 ) Iron status biomarkers (ferritin levels) ( 33536631 ) Loneliness ( 29970889 ) Loneliness (MTAG) ( 29970889 ) Medication use (antiglaucoma preparations and miotics) ( 31015401 ) Neuroticism ( 29255261 ) Refractive error ( 32231278 ) Sleep duration (short sleep) ( 30846698 )	Platelet reactivity in response to clopidogrel treatment ( 32472697 )
Interacting Genes		10 interacting genes: CSNK2A1 FYN ITSN1 ITSN2 KHDRBS1 LBR PLXNA2 PRPF40A SNRPB SYNJ1	30 interacting genes: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 FOXRED1 GRB2 ITSN1 LRRK2 PACSIN1 PACSIN2 PACSIN3 PAX6 PPP3CA RASAL2 SH3BP1 SH3D19 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SH3YL1 SORBS1 SORBS2
Entrez ID		23360	8867
HPRD ID		10996	09182
Ensembl ID		ENSG00000109920	ENSG00000159082
Uniprot IDs		Q8N3X1	A0A0D9SGJ6 B9EGN3 C9JFZ1 J3KQV8 O43426 Q05CZ1
PDB IDs		Not available	1W80 2DNR 2VJ0 7A0V
GO Terms Enriched among Interactors		Clathrin-dependent Synaptic Vesicle Endocytosis Presynaptic Endocytosis Synaptic Vesicle Endocytosis Vesicle-mediated Transport In Synapse Intracellular Vesicle U2-type Prespliceosome U1 SnRNP Clathrin-dependent Endocytosis MRNA Metabolic Process Regulation Of Cell Morphogenesis Cellular Response To Glycine Response To Singlet Oxygen Positive Regulation Of Endosome Organization Grb2-Sos Complex	Endocytosis Import Into Cell Vesicle-mediated Transport Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle-mediated Transport In Synapse Regulation Of Endocytosis Glutamatergic Synapse Endosome Regulation Of Vesicle-mediated Transport Postsynaptic Endocytic Zone Clathrin-dependent Endocytosis Clathrin-coated Pit Lipid Binding Establishment Of Localization In Cell Regulation Of Cellular Component Organization Receptor-mediated Endocytosis Cytosol Endolysosome Membrane Cytoskeleton Organization Clathrin-coated Endocytic Vesicle Receptor Internalization Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Plasma Membrane Postsynaptic Neurotransmitter Receptor Internalization Synapse Positive Regulation Of Endocytosis Cell Projection Morphogenesis Negative Regulation Of Transport Intracellular Protein Localization Cellular Localization AP-2 Adaptor Complex Regulation Of Transport Cytoplasmic Vesicle Membrane Organization Plasma Membrane Tubulation Regulation Of Protein Localization To Plasma Membrane Phospholipid Binding Intracellular Transport Intracellular Protein Transport Synaptic Vesicle Identical Protein Binding Clathrin Coat Assembly Cell Projection Negative Regulation Of Endocytosis Clathrin-coated Endocytic Vesicle Membrane Neuron Projection Morphogenesis Cytoskeletal Protein Binding Regulation Of Protein Localization To Cell Periphery