DMXL2 and RAB3A

Number of citations: 0 (PubMedID 11809763)
Data Source: HPRD (in vivo)

		DMXL2	RAB3A
Name		Dmx like 2	RAB3A, member RAS oncogene family
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle RAVE Complex Synapse Neuronal Dense Core Vesicle	Acrosomal Vesicle Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Synaptic Vesicle Membrane Transport Vesicle Axon Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Vesicle Cell Projection Terminal Bouton Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane Presynapse Postsynapse Extracellular Vesicle
	Molecular Function	Small GTPase Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein-macromolecule Adaptor Activity GTP-dependent Protein Binding Myosin V Binding Metal Ion Binding
	Biological Process	Vacuolar Acidification	Plasma Membrane Repair Respiratory System Process Exocytosis Mitochondrion Organization Neuromuscular Synaptic Transmission Axonogenesis Post-embryonic Development Protein Transport Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Lung Development Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Lysosome Localization Synaptic Vesicle Recycling Constitutive Secretory Pathway Regulated Exocytosis Positive Regulation Of Exocytosis Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Transport Maintenance Of Presynaptic Active Zone Structure Sensory Perception Of Touch Response To Electrical Stimulus Establishment Of Localization In Cell Acrosomal Vesicle Exocytosis Evoked Neurotransmitter Secretion Synaptic Vesicle Clustering Regulation Of Presynaptic Dense Core Granule Exocytosis Positive Regulation Of Regulated Secretory Pathway Regulation Of Plasma Membrane Repair
Pathways		None	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
GWAS		BMI (adjusted for smoking behaviour) ( 28443625 ) Body mass index ( 25673413 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) C-reactive protein levels ( 30388399 ) Intelligence (MTAG) ( 29326435 ) Triglyceride levels ( 32203549 )	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189 )
Interacting Genes		5 interacting genes: AKTIP ETS2 MTNR1B PCNT RAB3A	32 interacting genes: A2M ADRB2 AP1M2 APP CASK CHM CHML CHRM4 DMXL2 ECSIT EGFR GRSF1 KRTAP10-8 MAST1 MYO5A PSEN1 RAB3IL1 RAB3IP RABAC1 RABGGTB RABIF REP15 RIMS1 RIMS2 RNF32 RPH3A RPH3AL SGSM2 SNCA SYTL4 SYTL5 VRTN
Entrez ID		23312	5864
HPRD ID		10188	01535
Ensembl ID		ENSG00000104093	ENSG00000105649
Uniprot IDs		H0YLM8 Q8TDJ6	A0A024R7I7 P20336
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Ectodermal Cell Fate Commitment Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Constitutive Secretory Pathway Synaptic Vesicle Maturation Regulation Of Presynaptic Dense Core Granule Exocytosis Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Regulation Of Plasma Membrane Repair Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Acrosomal Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Dense Core Granule Exocytosis Evoked Neurotransmitter Secretion Maintenance Of Presynaptic Active Zone Structure Clathrin-sculpted Monoamine Transport Vesicle Membrane Sensory Perception Of Touch FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Primitive Streak Formation Cell Fate Commitment Involved In Formation Of Primary Germ Layer Nuclear Glucocorticoid Receptor Binding Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Vesicle Organization Synaptic Vesicle Clustering Regulation Of Short-term Neuronal Synaptic Plasticity Presynaptic Active Zone Organization Positive Regulation Of Protein Binding HOPS Complex Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Plasma Membrane Organization Myosin V Binding Synaptic Vesicle Recycling Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Nervous System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Ubiquitin-like Protein Transferase Activity Positive Regulation Of Circadian Rhythm Regulation Of Protein Transport GTP-dependent Protein Binding	Small GTPase Binding Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Intracellular Transport Intracellular Protein Localization Rab-protein Geranylgeranyltransferase Complex Synaptic Vesicle Priming Regulation Of Exocytosis Protein Geranylgeranylation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Vesicle-mediated Transport Synapse Intracellular Protein Transport Protein Prenylation Secretion By Cell Neurexin Family Protein Binding Exocytosis Modulation Of Excitatory Postsynaptic Potential Cytoplasmic Vesicle Secretion Regulation Of Regulated Secretory Pathway Synaptic Vesicle Positive Regulation Of Vesicle Fusion Neuronal Dense Core Vesicle Signal Release Positive Regulation Of Exocytosis Astrocyte Activation Involved In Immune Response Rab Geranylgeranyltransferase Activity Regulation Of Neurotransmitter Secretion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Neurotransmitter Transport Synaptic Vesicle Exocytosis Regulation Of Vesicle Fusion Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Neurotransmitter Secretion Regulation Of Nervous System Process Regulation Of Secretion By Cell Structural Constituent Of Presynaptic Active Zone Modulation Of Inhibitory Postsynaptic Potential Maintenance Of Presynaptic Active Zone Structure Synapse Organization Regulation Of Synaptic Vesicle Exocytosis Presynaptic Membrane Cellular Response To Amyloid-beta