MTUS2 and CXCL11

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		MTUS2	CXCL11
Name		microtubule associated scaffold protein 2	C-X-C motif chemokine ligand 11
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytoskeleton Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Intercellular Bridge	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Microtubule Binding Protein Homodimerization Activity	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CXCR3 Chemokine Receptor Binding
	Biological Process	None	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling T Cell Chemotaxis Killing Of Cells Of Another Organism Regulation Of Cell Population Proliferation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway
Pathways		None	Chemokine receptors bind chemokines G alpha (i) signalling events
GWAS		HDL cholesterol levels in HIV infection ( 33109212 ) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597 ) Insomnia (caffeine-induced) ( 22754043 ) Obesity-related traits ( 23251661 ) Triptolide cytotoxicity ( 26121980 )	Blood protein levels ( 30072576 ) Hippocampal volume ( 29274321 ) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952 )
Interacting Genes		327 interacting genes: ABHD15 ACSM1 AEN AIRIM AKT1 ANKRD11 ANKS1A ANXA2R-AS1 AQP1 ARL4A ARNT2 AXIN1 BANF2 BARD1 BCL6 BEX2 BMP7 BYSL C19orf44 C1orf216 C1orf35 C21orf58 C8orf34 CACNB3 CATIP CATSPER1 CATSPERT CBX8 CCAR1 CCDC116 CCDC120 CCDC146 CCDC17 CCDC185 CCDC187 CCDC198 CCDC60 CCHCR1 CDC20B CDC5L CDC7 CDC73 CDK18 CDK5R1 CDKL3 CDKN1A CDKN1B CEP57L1 CEP95 CERK CHIC2 CNNM3 COG2 CREB5 CRY2 CSF1 CTSZ CWF19L2 CXCL11 CXCL16 CYSLTR2 DCDC2B DCTN4 DCX DDX6 DHRS1 DLGAP4 DLGAP5 DMRT3 DOCK2 DSCR9 DTNB EHHADH EIF3D ENKD1 ENPP7 EXOC8 FAM107A FAM110A FAM124B FAM13C FAM161A FAM161B FAM74A4 FAM90A1 FASTKD5 FBXL18 FBXO34 FBXW5 FCHSD2 FHL3 FLYWCH1 FNDC11 FXR1 GADD45GIP1 GAL3ST2 GARIN5B GAS2L2 GEM GGN GNL3L GOLGA2P11 GPKOW GRAP2 GSTP1 GTF2I GTPBP10 HAPLN2 HAUS1 HBZ HCK HDAC4 HOXB5 HOXB9 HSF2 ICAM4 IL16 INO80B IQCE ITGB4 ITGB5 ITSN1 JMY JOSD1 JRK KANK2 KAT5 KIF1A KIFC3 KRT6A KRT75 KRT76 LENG1 LIMS2 LINC00636 LMO2 LMO3 LMO4 LNX1 LRR1 LYSMD1 MAGEA8 MARK4 MBD3 METTL17 MFAP1 MOS MRPL11 MTMR6 MYO15B MYOM1 MYPOP NDEL1 NDOR1 NEFL NELFE NHSL2 NTAQ1 NUBPL NUDT10 NXF1 ODAD3 ODF1 PCDHB14 PDE4DIP PDZD4 PIBF1 PIN1 PKN1 PKN3 PKP2 PLEKHN1 PLK4 PLSCR4 POLDIP2 POLDIP3 PPHLN1 PPP1R18 PRKAA1 PRKAA2 PRPF18 PRPF31 PRR35 PSMA1 PSMB1 PTCD1 PTK7 PTPMT1 RAB3IL1 RALY RANBP3L RAP1B RASAL3 RASD1 RBM41 RCOR3 RGS2 RHPN1 RIBC2 RNF6 ROBO3 RPA1 RPL9 RPS19BP1 RTP5 SAMD4A SCEL SCNM1 SDCBP SELENOM SETD5 SH2D4A SH3RF2 SHFL SLC22A5 SLC23A1 SLC25A42 SLC25A48 SLC25A6 SLIRP SMARCD1 SMARCE1 SMG9 SNAI1 SNHG11 SNRPA SNRPB2 SNW1 SPATA8 SPATC1L SPG21 SPG7 STK16 SYT6 TACO1 TAF13 TBC1D22B TCEA2 TCEANC TCHP TEAD4 TEPSIN THAP7 TLE5 TNIP3 TNNI1 TP53RK TRIM29 TRIM42 TSGA10IP TSHZ3 TTC23 TTLL10 TULP2 TXN2 UBC UBTFL1 USP2 USP22 UTP14C VASN WAC ZBTB16 ZBTB38 ZBTB47 ZC2HC1C ZFC3H1 ZFHX3 ZFP1 ZFP2 ZFP64 ZFYVE21 ZMAT2 ZMYND10 ZNF124 ZNF136 ZNF17 ZNF20 ZNF224 ZNF23 ZNF230 ZNF232 ZNF239 ZNF250 ZNF266 ZNF3 ZNF329 ZNF337 ZNF35 ZNF408 ZNF410 ZNF414 ZNF415 ZNF417 ZNF426 ZNF438 ZNF439 ZNF440 ZNF48 ZNF490 ZNF497 ZNF512B ZNF557 ZNF564 ZNF572 ZNF580 ZNF581 ZNF587 ZNF599 ZNF607 ZNF613 ZNF624 ZNF648 ZNF655 ZNF669 ZNF670 ZNF696 ZNF76 ZNF764 ZNF774 ZNF775 ZNF785 ZNF792 ZNF837 ZNF844 ZSCAN12 ZSCAN26	25 interacting genes: CCL1 CCL11 CCL13 CCL20 CCL21 CCL24 CCL25 CCL26 CCL5 CCL8 CCR3 CXCL10 CXCL12 CXCL14 CXCL2 CXCL9 CXCR3 DPP4 LRRK2 MTUS2 PF4 PF4V1 PPBP SMARCB1 XCL1
Entrez ID		23281	6373
HPRD ID		11108	05329
Ensembl ID		ENSG00000132938	ENSG00000169248
Uniprot IDs		Q5JR59	O14625
PDB IDs		Not available	1RJT 8HNK
GO Terms Enriched among Interactors		Regulation Of Transcription By RNA Polymerase II Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Regulation Of RNA Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Metal Ion Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Protein K6-linked Ubiquitination Microtubule-based Process Spliceosomal Complex Lipid Droplet Disassembly	Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Antimicrobial Humoral Response Cytokine Activity Leukocyte Chemotaxis Humoral Immune Response Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Leukocyte Migration Granulocyte Migration Cell Migration Killing Of Cells Of Another Organism Myeloid Leukocyte Migration Cell Motility Inflammatory Response Cell Killing CCR Chemokine Receptor Binding Defense Response Eosinophil Chemotaxis Defense Response To Symbiont Eosinophil Migration Defense Response To Other Organism Immune Response Cytokine-mediated Signaling Pathway Immune System Process Response To Other Organism Extracellular Space Response To External Biotic Stimulus Regulation Of Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Response To Stress CXCR Chemokine Receptor Binding Positive Regulation Of Locomotion Extracellular Region Mononuclear Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Migration Positive Regulation Of Leukocyte Migration Regulation Of Cell Motility Chemokine Receptor Binding Regulation Of Chemotaxis Positive Regulation Of T Cell Migration Positive Regulation Of Chemotaxis Positive Regulation Of Lymphocyte Migration Cell Surface Receptor Signaling Pathway