ADGRL2 and SHANK2

Number of citations: 0 (PubMedID 10964907)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		ADGRL2	SHANK2
Name		adhesion G protein-coupled receptor L2	SH3 and multiple ankyrin repeat domains 2
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse Postsynaptic Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Neurofilament Plasma Membrane Postsynaptic Density Membrane Apical Plasma Membrane Growth Cone Brush Border Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Latrotoxin Receptor Activity Carbohydrate Binding	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Excitatory Synapse Assembly	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Associative Learning Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Synapse Organization Cognition Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior
Pathways		None	Neurexins and neuroligins Neurexins and neuroligins
GWAS		Cataracts ( 34127677 ) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856 ) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136 ) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001 ) Low density lipoprotein cholesterol levels ( 30498476 ) Major depressive episode treated with electroconvulsive therapy ( 33483693 )	Bipolar disorder ( 31043756 34002096 ) Eosinophilic esophagitis ( 34506852 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Hip circumference ( 28552196 ) Hodgkin's lymphoma ( 34216518 ) Kawasaki disease ( 33692975 ) Late-onset Alzheimer's disease ( 27770636 ) Obesity-related traits ( 23251661 ) Response to fenofibrate (adiponectin levels) ( 23149075 ) Urate levels in obese individuals ( 25811787 )
Interacting Genes		3 interacting genes: NCK1 SHANK1 SHANK2	21 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 AKT1 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		23266	22941
HPRD ID		06116	04479
Ensembl ID		ENSG00000117114	ENSG00000162105
Uniprot IDs		A0A6I8PIV6 A0A6I8PLG0 A0A6I8PTT2 A0A8I5KUX3 O95490	A0A590UJ45 A6NHU9 Q9UPX8
PDB IDs		Not available	8ATJ 8B10
GO Terms Enriched among Interactors		Synaptic Receptor Adaptor Activity Vocalization Behavior Signaling Receptor Complex Adaptor Activity Ionotropic Glutamate Receptor Binding Social Behavior Associative Learning SH3 Domain Binding Determination Of Affect Somatostatin Receptor Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cap-independent Translational Initiation Eukaryotic Initiation Factor EIF2 Binding Positive Regulation Of Cap-dependent Translational Initiation Dendritic Spine Learning Adult Behavior Structural Constituent Of Postsynaptic Density Regulation Of Signal Transduction Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Habituation Sensory Processing Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Postsynaptic Membrane Maintenance Of Postsynaptic Density Structure AMPA Selective Glutamate Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cytoplasmic Translational Initiation Regulation Of Actin Filament Organization Positive Regulation Of Translation In Response To Stress Postsynaptic Density Learning Or Memory Synapse Organization Nonassociative Learning Ankyrin Repeat Binding Negative Regulation Of Signal Transduction Signal Complex Assembly Regulation Of Translation In Response To Endoplasmic Reticulum Stress Substrate-dependent Cell Migration, Cell Extension Regulation Of Actin Cytoskeleton Organization Regulation Of Translational Initiation In Response To Stress Cognition Neuron Projection Righting Reflex Maintenance Of Postsynaptic Specialization Structure Olfactory Behavior Negative Regulation Of Cell Communication Negative Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Signaling	Synapse Glutamatergic Synapse Postsynaptic Specialization Postsynapse Postsynaptic Density Neuron Projection Modulation Of Chemical Synaptic Transmission Vesicle Scission Latrotoxin Receptor Activity Modification Of Postsynaptic Structure Dendritic Spine Modification Of Synaptic Structure Plasma Membrane Cell Projection Morphogenesis Cell Projection PDZ Domain Binding Regulation Of Synapse Organization Regulation Of Cellular Component Organization Membrane Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Cell Projection Organization Membrane Presynapse Cellular Response To Peptide Neuron Spine Synapse Organization Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Regulation Of Nervous System Development Cell Projection Organization Cholinergic Synapse Cell Junction Organization Protein Localization To Membrane Receptor-mediated Endocytosis Clathrin-coated Pit Negative Regulation Of Cellular Component Organization Cell Cortex Signal Transduction Endocytic Vesicle Membrane Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Molecular Adaptor Activity Lamellipodium Neuromuscular Junction Proline-rich Region Binding Intracellular Protein Transport Neuron Projection Terminus Calcineurin-NFAT Signaling Cascade G Protein-coupled Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse