SCFD1 and USP22

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid)

		SCFD1	USP22
Name		sec1 family domain containing 1	ubiquitin specific peptidase 22
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi-associated Vesicle Cis-Golgi Network Cytosol Membrane Golgi Cisterna Membrane	SAGA Complex Nucleus Nucleoplasm Cytoplasm Transcription Factor TFTC Complex
	Molecular Function	Protein Binding Syntaxin Binding Protein-containing Complex Binding	Transcription Coactivator Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Histone H4 Acetyltransferase Activity Hydrolase Activity Enzyme Binding Metal Ion Binding Histone H2B Deubiquitinase Activity Histone H2A Deubiquitinase Activity
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Post-Golgi Vesicle-mediated Transport Response To Toxic Substance Protein Transport Vesicle-mediated Transport Regulation Of Protein Transport Regulation Of ER To Golgi Vesicle-mediated Transport Negative Regulation Of Autophagosome Assembly	G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Repair Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Proteolysis Embryo Development Ending In Birth Or Egg Hatching Protein Deubiquitination Positive Regulation Of Type I Interferon Production Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle
Pathways		COPII-mediated vesicle transport RHOA GTPase cycle	HATs acetylate histones Ub-specific processing proteases
GWAS		Amyotrophic lateral sclerosis ( 27455348 29566793 ) Cognitive decline (age-related) ( 28078323 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 23823483 ) Night sleep phenotypes ( 27126917 )	Body mass index ( 26426971 ) Mosquito bite size ( 28199695 )
Interacting Genes		5 interacting genes: DLST PPBP STX5 USO1 USP22	17 interacting genes: BAG4 CEBPA H2AC20 H2AC4 H2BC21 H2BC3 HEXA MRPL10 MRPL44 MTUS2 PALB2 PSME1 PTGS2 RCAN1 SCFD1 UBC ZEB1
Entrez ID		23256	23326
HPRD ID		10210	19411
Ensembl ID		ENSG00000092108	ENSG00000124422
Uniprot IDs		A0A7I2V590 B7Z5N7 B7Z738 H0YIZ7 Q8WVM8	Q9UPT9
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Dihydrolipoyllysine-residue Succinyltransferase Activity ER To Golgi Transport Vesicle Membrane Vesicle Docking Organelle Localization By Membrane Tethering Membrane Docking Golgi Vesicle Docking Vesicle Fusion Organelle Membrane Fusion Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Organelle Fusion L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Oxoadipate Dehydrogenase Complex L-lysine Catabolic Process Membrane Fusion Histone H2B Deubiquitinase Activity Lysine Catabolic Process Oxoglutarate Dehydrogenase Complex Golgi Disassembly Positive Regulation Of Protein Catabolic Process Vesicle Fusion With Golgi Apparatus Histone H2A Deubiquitinase Activity Succinyl-CoA Metabolic Process D-glucose Transmembrane Transporter Activity Golgi Vesicle Transport Histone H4 Acetyltransferase Activity Amide Catabolic Process CXCR Chemokine Receptor Binding Vesicle Organization Cadherin Binding 2-oxoglutarate Metabolic Process Platelet Alpha Granule Early Endosome To Golgi Transport Regulation Of Golgi Organization Bounding Membrane Of Organelle Regulation Of Protein Catabolic Process Transcytosis Transcription Factor TFTC Complex	Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome