SCFD1 and DLST

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		SCFD1	DLST
Name		sec1 family domain containing 1	dihydrolipoamide S-succinyltransferase
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi-associated Vesicle Cis-Golgi Network Cytosol Membrane Golgi Cisterna Membrane	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Oxoglutarate Dehydrogenase Complex Oxoadipate Dehydrogenase Complex
	Molecular Function	Protein Binding Syntaxin Binding Protein-containing Complex Binding	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Post-Golgi Vesicle-mediated Transport Response To Toxic Substance Protein Transport Vesicle-mediated Transport Regulation Of Protein Transport Regulation Of ER To Golgi Vesicle-mediated Transport Negative Regulation Of Autophagosome Assembly	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine
Pathways		COPII-mediated vesicle transport RHOA GTPase cycle	Glycine degradation OGDH complex synthesizes succinyl-CoA from 2-OG Protein lipoylation OADH complex synthesizes glutaryl-CoA from 2-OA
GWAS		Amyotrophic lateral sclerosis ( 27455348 29566793 ) Cognitive decline (age-related) ( 28078323 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 23823483 ) Night sleep phenotypes ( 27126917 )	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Appendicular lean mass ( 33097823 ) Depression ( 29700475 ) Eosinophil count ( 32888494 ) Mood instability ( 29187730 ) Non-small cell lung cancer ( 23144319 )
Interacting Genes		5 interacting genes: DLST PPBP STX5 USO1 USP22	21 interacting genes: ARIH2 CCDC86 DLG5 FLII GRIK1 HUNK NAP1L1 NDRG1 OGDH OGT PAK4 PFN2 RUSC2 SCFD1 SIAH2 TUBB4B UMPS USP7 WEE2-AS1 ZBTB16 ZHX1
Entrez ID		23256	1743
HPRD ID		10210	00520
Ensembl ID		ENSG00000092108	ENSG00000119689
Uniprot IDs		A0A7I2V590 B7Z5N7 B7Z738 H0YIZ7 Q8WVM8	B7Z6J1 P36957
PDB IDs		Not available	6H05
GO Terms Enriched among Interactors		Dihydrolipoyllysine-residue Succinyltransferase Activity ER To Golgi Transport Vesicle Membrane Vesicle Docking Organelle Localization By Membrane Tethering Membrane Docking Golgi Vesicle Docking Vesicle Fusion Organelle Membrane Fusion Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Organelle Fusion L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Oxoadipate Dehydrogenase Complex L-lysine Catabolic Process Membrane Fusion Histone H2B Deubiquitinase Activity Lysine Catabolic Process Oxoglutarate Dehydrogenase Complex Golgi Disassembly Positive Regulation Of Protein Catabolic Process Vesicle Fusion With Golgi Apparatus Histone H2A Deubiquitinase Activity Succinyl-CoA Metabolic Process D-glucose Transmembrane Transporter Activity Golgi Vesicle Transport Histone H4 Acetyltransferase Activity Amide Catabolic Process CXCR Chemokine Receptor Binding Vesicle Organization Cadherin Binding 2-oxoglutarate Metabolic Process Platelet Alpha Granule Early Endosome To Golgi Transport Regulation Of Golgi Organization Bounding Membrane Of Organelle Regulation Of Protein Catabolic Process Transcytosis Transcription Factor TFTC Complex	None