RPRD2 and UPF1

Number of citations: 47 (PubMedID 15231747)
Data Source: HPRD (two hybrid)

		RPRD2	UPF1
Name		regulation of nuclear pre-mRNA domain containing 2	UPF1 RNA helicase and ATPase
Structure
GO Annotations	Cellular Component	Nucleoplasm Transcription Preinitiation Complex	Chromosome, Telomeric Region Chromatin P-body Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex Supraspliceosomal Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Complex Binding RNA Polymerase II C-terminal Domain Binding	Nucleotide Binding DNA Binding Chromatin Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Double-stranded DNA Helicase Activity Telomeric DNA Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	MRNA 3'-end Processing	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process DNA Replication DNA Repair MRNA Export From Nucleus Regulation Of Translational Termination Regulation Of Gene Expression Telomere Maintenance Via Semi-conservative Replication Regulation Of Telomere Maintenance Cell Cycle Phase Transition Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Histone MRNA Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
GWAS		Bitter non-alcoholic beverage consumption ( 31046077 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Broad depression or bipolar disorder ( 30626913 ) Caffeine consumption from tea ( 33287642 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Lung function (FEV1) ( 30175238 ) Neutrophil count ( 32888494 ) Refractive error ( 32231278 ) Schizophrenia ( 28991256 ) Spontaneous coronary artery dissection ( 32887874 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Attention deficit hyperactivity disorder ( 32595297 )
Interacting Genes		7 interacting genes: CSNK2A1 CTDSP1 MTNR1B PPP1CA PPP1CC SPOP UPF1	106 interacting genes: ABHD16A ACSS2 ATR CEBPA CSNK2B DCP1A DCP2 DXO EIF3A EIF3B EIF4A3 EXOSC2 EXOSC4 GNPTG HIRA LINC00113 LSM8 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NADSYN1 NDRG1 NDUFB10 PLEKHA5 PLEKHB2 POLR2A PTEN RHOXF2 RNF10 RPRD2 SMG1 SMG5 STAU1 SUMO2 UPF2 UPF3A UPF3B XRN1
Entrez ID		23248	5976
HPRD ID		11084	03254
Ensembl ID		ENSG00000163125	ENSG00000005007
Uniprot IDs		Q5VT52	A0A024R7L5 B3KY55 Q92900
PDB IDs		4FLB	2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP 6EJ5 6Z3R 8RXB
GO Terms Enriched among Interactors		Protein Dephosphorylation Phosphatase Activity PTW/PP1 Phosphatase Complex Protein Serine/threonine Phosphatase Activity Regulation Of Circadian Rhythm Dephosphorylation Phosphoprotein Phosphatase Activity Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Chromosome, Telomeric Region Rhythmic Process Double-strand Break Repair Via Nonhomologous End Joining Glycogen Metabolic Process Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Protein-containing Complex Binding Chromosome Organization Polysaccharide Metabolic Process Regulation Of Translation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Translational Initiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body DNA Repair Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Telomere Maintenance Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Regulation Of Protein-containing Complex Disassembly Telomere Organization Circadian Rhythm Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Double-stranded DNA Helicase Activity Supraspliceosomal Complex Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Muscle Cell Projection Membrane Positive Regulation Of Aggrephagy Regulation Of Neuronal Action Potential Dendritic Spine Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Transmission Of Nerve Impulse Glycogen Granule Positive Regulation Of Transmission Of Nerve Impulse	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression RNA Destabilization MRNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of Translation Negative Regulation Of Locomotion Regulation Of Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Angiogenesis Regulation Of RNA Stability Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus