SIK2 and CRTC2

Number of citations: 50 (PubMedID 29211348)
Data Source: BioGRID (imaging technique), HPRD (in vitro, in vivo)

		SIK2	CRTC2
Name		salt inducible kinase 2	CREB regulated transcription coactivator 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Transcription Coactivator Activity Protein Binding CAMP Response Element Binding Protein Binding
	Biological Process	Protein Phosphorylation Lipid Biosynthetic Process Intracellular Signal Transduction ERAD Pathway Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation	Gluconeogenesis Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cellular Response To CAMP
Pathways		None	Transcriptional activation of mitochondrial biogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs		Fostamatinib	None
GWAS		A body shape index ( 34021172 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011 ) Asthma ( 34103634 30929738 31361310 31619474 32296059 ) Asthma (adult onset) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Brain morphology (MOSTest) ( 32665545 ) Diastolic blood pressure ( 30224653 ) Eosinophil percentage of white cells ( 32888494 ) Fish- and plant-related diet ( 32066663 ) Household income (MTAG) ( 31844048 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) Primary sclerosing cholangitis ( 23603763 27992413 ) Triglyceride levels ( 32154731 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Age at first birth ( 27798627 34211149 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cooked vegetable consumption ( 32066663 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Empathy quotient ( 29527006 ) Fish- and plant-related diet ( 32066663 ) Fruit consumption ( 32066663 ) Raw vegetable consumption ( 32066663 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		8 interacting genes: APP CRTC2 CRTC3 EP300 FBXW7 GABARAPL2 HDAC5 IRS1	15 interacting genes: ATPAF2 CCDC57 CDC23 CREB1 MFHAS1 NEDD4 PPP3CA PRKAA1 SIK1 SIK2 SIK3 SUFU YWHAB YWHAG YWHAZ
Entrez ID		23235	200186
HPRD ID		12348	12347
Ensembl ID		ENSG00000170145	ENSG00000160741
Uniprot IDs		Q9H0K1	Q53ET0
PDB IDs		Not available	4HTM
GO Terms Enriched among Interactors		Cellular Response To Oxygen-containing Compound Cellular Response To CAMP Positive Regulation Of Transcription By RNA Polymerase II Protein Tetramerization Response To CAMP CAMP Response Element Binding Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Catabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Generation Of Precursor Metabolites And Energy Response To Purine-containing Compound Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Insulin Receptor Binding Regulation Of Establishment Of Protein Localization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Leukocyte Activation Protein Homooligomerization Positive Regulation Of Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Macromolecule Metabolic Process Homeostatic Process Cell Activation Protein Complex Oligomerization Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Protein Kinase C Binding Protein-containing Complex Positive Regulation Of Gene Expression, Epigenetic Regulation Of Glycolytic Process Gluconeogenesis Transcription Coactivator Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Negative Regulation Of Metabolic Process Myeloid Cell Development Chemical Homeostasis Response To Light Stimulus Positive Regulation Of Establishment Of Protein Localization Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Regulation Of Carbohydrate Catabolic Process Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway	Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Protein Modification Process Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Negative Regulation Of Protein Localization Regulation Of TORC1 Signaling Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of TOR Signaling Protein Sequestering Activity Phosphorylation Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Negative Regulation Of Cell Communication Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Signaling Cellular Response To Glucose Starvation Protein Localization To Lysosome Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Targeting Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell TORC1 Signaling Negative Regulation Of Biosynthetic Process Protein Domain Specific Binding Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell TOR Signaling Positive Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of Immune Response To Tumor Cell Protein Localization To Vacuole Phosphate-containing Compound Metabolic Process Regulation Of Protein Localization Negative Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Regulation Of T Cell Mediated Immune Response To Tumor Cell Modification-dependent Protein Catabolic Process Negative Regulation Of Protein Import Into Nucleus Positive Regulation Of Immune Response To Tumor Cell Protein Catabolic Process Negative Regulation Of Metabolic Process Response To Light Stimulus Regulation Of Nucleocytoplasmic Transport