FLT3LG and FLT3

Number of citations: 0 (PubMedID 7505204)
Data Source: HPRD (in vivo)

		FLT3LG	FLT3
Name		fms related receptor tyrosine kinase 3 ligand	fms related receptor tyrosine kinase 3
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Cell Surface Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane Endosome Membrane Membrane Protein-containing Complex Receptor Complex
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Receptor Tyrosine Kinase Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Nuclear Glucocorticoid Receptor Binding Protein-containing Complex Binding Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	Signal Transduction Positive Regulation Of Cell Population Proliferation B Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Embryonic Hemopoiesis Dendritic Cell Differentiation	Leukocyte Homeostasis Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Cell Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Lymphocyte Proliferation Protein Autophosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation Liver Regeneration
Pathways		PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants	PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation FLT3 mutants bind TKIs STAT5 activation downstream of FLT3 ITD mutants KW2449-resistant FLT3 mutants semaxanib-resistant FLT3 mutants crenolanib-resistant FLT3 mutants gilteritinib-resistant FLT3 mutants lestaurtinib-resistant FLT3 mutants midostaurin-resistant FLT3 mutants pexidartinib-resistant FLT3 mutants ponatinib-resistant FLT3 mutants quizartinib-resistant FLT3 mutants sorafenib-resistant FLT3 mutants sunitinib-resistant FLT3 mutants tandutinib-resistant FLT3 mutants linifanib-resistant FLT3 mutants tamatinib-resistant FLT3 mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants
Drugs		None	Sorafenib Sunitinib XL999 Tandutinib Linifanib Lestaurtinib Midostaurin Ponatinib Nintedanib Pacritinib Tivozanib Fostamatinib Gilteritinib Brigatinib Fedratinib Amuvatinib Quizartinib Pexidartinib Pralsetinib
Diseases		None	Acute myeloid leukemia (AML)
GWAS		Monocyte percentage of white cells ( 32888494 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269 )	Apolipoprotein A1 levels ( 32203549 ) Autoimmune thyroid disease ( 32581359 ) Basophil count ( 32888494 ) Body mass index ( 25673413 29273807 ) Body size at age 10 ( 32376654 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) HDL cholesterol levels ( 32203549 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (thyroid preparations) ( 31015401 ) Monocyte count ( 29403010 32888494 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Non-albumin protein levels ( 29403010 ) Pancreatic cancer ( 25086665 ) Plateletcrit ( 32888494 ) Psoriasis ( 25854761 ) Rapid automised naming of digits ( 30741946 ) Serum total protein levels ( 29403010 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Tourette syndrome ( 30818990 ) White blood cell count ( 27863252 32888494 ) White blood cell count (monocyte) ( 28158719 )
Interacting Genes		5 interacting genes: FLT3 KITLG KRTAP5-9 PFN2 S100A6	18 interacting genes: CBL CBLB CTNNB1 ERBB2 FIZ1 FLT3LG GRB2 IKBKG INPP5D NCK1 PTPN11 PTPN12 PTPN6 SH3BP2 SLA SOCS1 SRC UBE2L6
Entrez ID		2323	2322
HPRD ID		02477	00635
Ensembl ID		ENSG00000090554	ENSG00000122025
Uniprot IDs		B7ZLY4 P49771	P36888
PDB IDs		1ETE 3QS7 3QS9 7NBI 7QDP 7ZV9	1RJB 3QS7 3QS9 4RT7 4XUF 5X02 6IL3 6JQR 7QDP 7ZV9 8XB1
GO Terms Enriched among Interactors		Positive Regulation Of Cell Population Proliferation Lymphocyte Proliferation Leukocyte Proliferation Hematopoietic Progenitor Cell Differentiation Vascular Endothelial Growth Factor Receptor Activity Positive Regulation Of Phosphorylation Common Myeloid Progenitor Cell Proliferation Pro-B Cell Differentiation Myeloid Progenitor Cell Differentiation Mononuclear Cell Proliferation Phosphatidylinositol 3-kinase Activator Activity Hemopoiesis Positive Regulation Of Protein Phosphorylation Mast Cell Apoptotic Process Regulation Of Melanocyte Differentiation Positive Regulation Of Mast Cell Proliferation Negative Regulation Of Mast Cell Apoptotic Process Melanocyte Migration Mast Cell Proliferation Mast Cell Migration Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Pigment Cell Differentiation Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Stem Cell Factor Receptor Binding Positive Regulation Of Melanocyte Differentiation Presynaptic Actin Cytoskeleton Organization Presynaptic Cytoskeleton Organization Negative Regulation Of Ruffle Assembly Positive Regulation Of Developmental Pigmentation Regulation Of Mast Cell Proliferation Positive Regulation Of Hematopoietic Stem Cell Proliferation Lymphoid Progenitor Cell Differentiation Positive Regulation Of Phosphate Metabolic Process Modification Of Postsynaptic Actin Cytoskeleton Monoatomic Ion Transmembrane Transporter Activity Regulation Of Developmental Pigmentation Tropomyosin Binding Nuclear Glucocorticoid Receptor Binding S100 Protein Binding Leukocyte Differentiation Positive Regulation Of Protein Modification Process Myeloid Cell Apoptotic Process Negative Regulation Of Epithelial Cell Migration Regulation Of Protein Phosphorylation Regulation Of Hematopoietic Stem Cell Proliferation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Phosphorylation Modification Of Postsynaptic Structure	Phosphotyrosine Residue Binding Receptor Tyrosine Kinase Binding Regulation Of Lymphocyte Activation Ephrin Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Activation ERBB Signaling Pathway Negative Regulation Of Immune System Process Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Activation Regulation Of Leukocyte Proliferation Cellular Response To Growth Factor Stimulus SH3 Domain Binding Response To Growth Factor Negative Regulation Of Leukocyte Activation Regulation Of MAPK Cascade Positive Regulation Of Lymphocyte Activation Negative Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Activation Positive Regulation Of Cell Activation Immune System Process Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Neutrophil Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Cell Activation Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Proliferation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Neutrophil Activation T Cell Receptor Signaling Pathway T Cell Costimulation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Neutrophil Activation Involved In Immune Response Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Cell Adhesion