ARHGEF9 and PLEKHA5

Number of citations: 36 (PubMedID 20936779)
Data Source: BioGRID (two hybrid)

		ARHGEF9	PLEKHA5
Name		Cdc42 guanine nucleotide exchange factor 9	pleckstrin homology domain containing A5
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Postsynaptic Density Synapse GABA-ergic Synapse Postsynaptic Specialization	Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynaptic Specialization Assembly	Reproductive System Development
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RHOQ GTPase cycle GABA receptor activation GABA receptor activation	Synthesis of PIPs at the plasma membrane
Diseases		Hyperekplexia Early infantile epileptic encephalopathy; Ohtahara syndrome	None
GWAS		Male-pattern baldness ( 28196072 )	Adult body size ( 32376654 ) Age at first sexual intercourse ( 34211149 ) Chronic mountain sickness ( 31417607 ) Daytime sleep phenotypes ( 27126917 ) Gut microbiota (bacterial taxa) ( 27694959 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848 ) Platelet reactivity in response to clopidogrel treatment ( 32472697 ) Thalamus volume ( 31530798 )
Interacting Genes		12 interacting genes: BCL6 CDC42 CFTR FAM90A1 GPHN IHO1 KHDRBS1 PLEKHA5 SMURF1 TBC1D22B TFIP11 TSGA10IP	30 interacting genes: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX MTCL2 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG
Entrez ID		23229	54477
HPRD ID		02337	09684
Ensembl ID		ENSG00000131089	ENSG00000052126
Uniprot IDs		A0A1B0GWI5 A0A5F9ZHY9 A0A5F9ZI31 B1AMR3 O43307	A0A8V8TQ09 A0A8V8TQJ8 A0A9L9PX43 Q9HAU0
PDB IDs		2YSQ	2DKP
GO Terms Enriched among Interactors		None	Structural Constituent Of Cytoskeleton Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Cytoskeleton Cytoskeleton Organization Double-stranded DNA Helicase Activity Intermediate Filament Organization Intermediate Filament Cadherin Binding Supramolecular Fiber Organization Extracellular Exosome Spectrin Vesicle Cytoskeletal Trafficking Contractile Muscle Fiber Centriole-centriole Cohesion Centriole Cytoskeletal Protein Binding Costamere Structural Molecule Activity Intracellular Protein Localization Ankyrin Binding Cytoskeleton-dependent Intracellular Transport Actin Cytoskeleton Organization Actin Filament Binding Purine Nucleoside Metabolic Process Epithelial Cell Differentiation Microtubule Anchoring Protein Localization To Centrosome Establishment Of Vesicle Localization Actin Filament-based Process Cytosol DATP Biosynthetic Process Adenosine Kinase Activity Membrane Organization Sarcolemma Metanephric Glomerular Basement Membrane Development MLL1 Complex Microtubule Binding Cilium Assembly Vesicle Localization Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle Actin Filament Capping Establishment Of Organelle Localization Regulation Of Protein-containing Complex Disassembly