JMJD6 and ANKEF1

Number of citations: 0 (PubMedID 23455924)
Data Source: BioGRID (two hybrid)

		JMJD6	ANKEF1
Name		jumonji domain containing 6, arginine demethylase and lysine hydroxylase	ankyrin repeat and EF-hand domain containing 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex	None
	Molecular Function	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3R2 Demethylase Activity Histone H4R3 Demethylase Activity Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Protein Demethylase Activity Transcription Regulator Activator Activity	Calcium Ion Binding Protein Binding
	Biological Process	Blood Vessel Development Kidney Development Sprouting Angiogenesis Chromatin Organization Chromatin Remodeling MRNA Processing Phagocytosis Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Cell Differentiation Lung Development Negative Regulation Of Protein Homooligomerization T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Apoptotic Cell Clearance Recognition Of Apoptotic Cell Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Membraneless Organelle Assembly	None
Pathways		HDMs demethylate histones Protein hydroxylation	None
GWAS		Neutrophil count ( 32888494 ) Retinal arteriolar caliber ( 23776548 )	Brain imaging measurements (variance) ( 32047264 ) Hip circumference ( 28552196 )
Interacting Genes		30 interacting genes: AEBP2 ANKEF1 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 IRF3 LARP7 LIAT1 NAA50 NFIX NHP2 OGT PRPF38A PSMC1 RNF5 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451	4 interacting genes: JMJD6 KDM1A SSBP3 VHL
Entrez ID		23210	63926
HPRD ID		05371	10652
Ensembl ID		ENSG00000070495	ENSG00000132623
Uniprot IDs		B2WTI3 B2WTI4 Q6NYC1	Q9NU02
PDB IDs		3K2O 3LD8 3LDB 6BNH 6GDY 6MEV	Not available
GO Terms Enriched among Interactors		Pre-mRNA 3'-splice Site Binding SnRNA Modification Nucleoplasm Nucleus	Protein Demethylase Activity Histone Demethylase Activity Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Positive Regulation Of Anterior Head Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Protein Homooligomerization Oxidative RNA Demethylase Activity P-TEFb Complex Binding Negative Regulation Of Protein Oligomerization DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process MRF Binding Response To Fungicide Guanine Metabolic Process Recognition Of Apoptotic Cell Transcription Elongation Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone H3K4 Demethylase Activity Oxidative Demethylation Peptidyl-lysine Hydroxylation Mesendoderm Development Formation Of Anatomical Boundary Transcription Regulator Complex Histone H3K9 Demethylase Activity Head Morphogenesis Demethylation Transcription Regulator Activator Activity Transcription Coactivator Activity Positive Regulation Of Cell Size Phagocytosis, Recognition Regulation Of Transcription By RNA Polymerase II DNA Repair Complex Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Hydroxylation Positive Regulation Of Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II RNA Splicing