GANAB and PRKCSH

Number of citations: 172 (PubMedID 40437099)
Data Source: BioGRID (biochemical), HPRD (in vitro)

		GANAB	PRKCSH
Name		glucosidase II alpha subunit	PRKCSH beta subunit of glucosidase II
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Membrane Glucosidase II Complex Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Glucosidase II Complex Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Catalytic Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Glucan 1,3-alpha-glucosidase Activity Alpha-glucosidase Activity Glc2Man9GlcNAc2 Oligosaccharide Glucosidase Activity	Protein Kinase C Binding Calcium Ion Binding Protein Binding Transmembrane Transporter Binding Metal Ion Binding Phosphoprotein Binding
	Biological Process	Carbohydrate Metabolic Process N-glycan Processing	Liver Development N-glycan Processing Intracellular Signal Transduction
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle Calnexin/calreticulin cycle Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) N-glycan trimming in the ER and Calnexin/Calreticulin cycle Advanced glycosylation endproduct receptor signaling Post-translational protein phosphorylation Calnexin/calreticulin cycle Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs		Miglitol	None
Diseases		None	Polycystic liver disease
GWAS		A body shape index ( 34021172 ) Hip index ( 34021172 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Presence of antiphospholipid antibodies ( 27098658 ) Serum metabolite levels (CMS) ( 31636271 )
Interacting Genes		11 interacting genes: AURKB CCNH CREB3L4 CSNK2A1 LINC01554 MAPK8 PRKCSH PRRC2A PTPRC RAP1A RNF10	11 interacting genes: ARL4D CANX ESR1 FXR1 GANAB GBA3 GET4 PTPRC RGS2 RPS6 VDR
Entrez ID		23193	5589
HPRD ID		03516	03518
Ensembl ID		ENSG00000089597	ENSG00000130175
Uniprot IDs		B4DIW2 B4DSM6 B4DZ53 E9PKU7 F5H6X6 Q14697	B4DJQ5 K7ELL7 P14314
PDB IDs		8D43 8EMR	8D43 8EMR
GO Terms Enriched among Interactors		Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Protein Localization To Chromosome Protein Localization To Site Of Double-strand Break	Maternal Process Involved In Female Pregnancy Mammary Gland Branching Involved In Pregnancy Nucleolus Branching Involved In Mammary Gland Duct Morphogenesis Nuclear Steroid Receptor Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Membrane RNA Binding ERAD Pathway Presynapse Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Estrogen Receptor Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Cell Population Proliferation Transcription Preinitiation Complex Assembly TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Transcription Coregulator Binding Regulation Of MiRNA Transcription Positive Regulation Of Catalytic Activity Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of MiRNA Metabolic Process Developmental Process Involved In Reproduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Steroid Hormone Receptor Signaling Pathway Regulation Of Inflammatory Response Negative Regulation Of Biosynthetic Process Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Receptor Activity Antral Ovarian Follicle Growth Negative Regulation Of Gene Expression Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Cell Differentiation DN2 Thymocyte Differentiation Plasma Membrane Raft Distribution Cytoplasmic Side Of Plasma Membrane Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Differentiation Response To Alcohol Membrane Microdomain Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Negative Regulation Of Glycine Import Across Plasma Membrane Adenylate Cyclase Inhibitor Activity Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Negative Regulation Of Transmembrane Transport Cytoplasmic Ribonucleoprotein Granule