SEPTIN8 and JADE1

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		SEPTIN8	JADE1
Name		septin 8	jade family PHD finger 1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Septin Ring Microtubule Cytoskeleton Membrane Axon Synaptic Vesicle Membrane Septin Complex Cytoplasmic Vesicle Cell Division Site Cell Projection Synapse Presynapse	Histone Acetyltransferase Complex Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Nuclear Speck Ciliary Basal Body Cell Projection
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Molecular Adaptor Activity	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Histone H3K14 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity
	Biological Process	Intracellular Protein Localization Regulation Of Protein Stability Regulation Of Intracellular Protein Transport Regulation Of SNARE Complex Assembly Cytoskeleton-dependent Cytokinesis	Regulation Of Cell Growth Regulation Of DNA Replication Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Growth Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process
Pathways		None	HATs acetylate histones
GWAS		No GWAS studies recorded	Arterial stiffness index ( 31235810 ) Bone mineral density (total hip) ( 29883787 )
Interacting Genes		11 interacting genes: A2M CDK14 ESR1 JADE1 KMT2B PPHLN1 SEPTIN4 SEPTIN5 SH3GL1 SH3GL3 SPTBN1	16 interacting genes: AKT1 CFTR CTNNB1 H3C14 H4C1 HMOX2 PFDN1 SEPTIN8 SMN1 TK1 UBE2E1 UBE2H UBE3A VHL YJU2 ZNF148
Entrez ID		23176	79960
HPRD ID		12228	10151
Ensembl ID		ENSG00000164402	ENSG00000077684
Uniprot IDs		A6NFQ9 B7ZVZ1 Q92599	B4E2E2 Q6IE81
PDB IDs		6UPR 6WSM	8GDX 8GE0
GO Terms Enriched among Interactors		Cytoskeleton-dependent Cytokinesis Cell Division Site Septin Ring Septin Complex Central Nervous System Development Presynapse Protein Localization To Chromatin	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Negative Regulation Of TOR Signaling Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Proteasomal Protein Catabolic Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Regulation Of TORC1 Signaling Protein K48-linked Ubiquitination Regulation Of Protein Localization Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Catabolic Process Disordered Domain Specific Binding Macromolecule Catabolic Process Regulation Of TOR Signaling 14-3-3 Protein Binding Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Enzyme Binding Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Protein Localization To Cell Surface Negative Regulation Of Intracellular Signal Transduction Protein K11-linked Ubiquitination Protein-containing Complex Regulation Of Myelination Proteolysis Regulation Of TRNA Methylation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein-containing Complex Assembly Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Sperm Entry Positive Regulation Of Golgi Lumen Acidification Nucleus Response To Ketone Regulation Of Cellular Localization Microtubule Cytoskeleton Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of TORC1 Signaling Negative Regulation Of Protein Localization To Lysosome Regulation Of Post-translational Protein Modification