SEPTIN6 and NSD3

Number of citations: 0 (PubMedID 23455924)
Data Source: BioGRID (two hybrid)

		SEPTIN6	NSD3
Name		septin 6	nuclear receptor binding SET domain protein 3
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Spindle Cytoskeleton Cilium Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Midbody Septin Complex Motile Cilium Cell Division Site Cleavage Furrow Septin Collar Cell Projection Axon Terminus Sperm Annulus Presynapse	Chromatin Nucleus Nucleoplasm Chromosome
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Molecular Adaptor Activity	Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Histone H3K4 Methyltransferase Activity Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3K27 Methyltransferase Activity Transcription Regulator Activator Activity Histone H3 Methyltransferase Activity Histone H3K4 Dimethyltransferase Activity Histone H3K27 Trimethyltransferase Activity Histone H3K27 Dimethyltransferase Activity
	Biological Process	Mitotic Cytokinesis Spermatogenesis Intracellular Protein Localization Cell Differentiation Cell Division Cytoskeleton-dependent Cytokinesis	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of DNA-templated Transcription
Pathways		None	PKMTs methylate histone lysines
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		15 interacting genes: CDC42EP2 CDC42EP3 CEBPA CRK KDM1A MORN4 NSD3 PLEKHF2 RHOU S100A4 SEPTIN1 SEPTIN2 SEPTIN9 SH3KBP1 TK1	41 interacting genes: AKT1 ATM BCAR3 CASP8 CBLC CBX3 CBX5 CDKN2A CHEK2 DAXX DOCK7 ESR1 ETV3 FGFR4 GLIS2 GLYR1 H1-1 H3-5 H3C1 H4C1 HOXC4 MLLT6 MNDA NFIC PAX2 PPM1D RB1CC1 SEPTIN6 SLU7 SOX3 SOX4 SPAG8 STAC3 TCF3 TEAD2 TERT TGFB1 TRIM55 TRIM63 UBE2I ZNF557
Entrez ID		23157	54904
HPRD ID		06716	06155
Ensembl ID		ENSG00000125354	ENSG00000147548
Uniprot IDs		B1AMS2 Q14141 Q541S4 Q548C9	Q9BZ95
PDB IDs		2QAG 6UPA 6WBP 7M6J	2DAQ 2NCZ 2ND1 4GND 4GNE 4GNF 4GNG 4RXJ 5UPD 6CEN 6G24 6G25 6G27 6G29 6G2B 6G2C 6G2E 6G2F 6G2O 6G3P 6G3T 7CRP 7CRQ 7CRR 7JYN
GO Terms Enriched among Interactors		Regulation Of Cell Shape Cell Division Site Septin Ring Septin Complex Regulation Of Cell Morphogenesis Organelle Organization Cytoskeleton-dependent Cytokinesis Microtubule Cytoskeleton Positive Regulation Of Pseudopodium Assembly Actin Cytoskeleton Cytoskeleton Organization GTPase Activity Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Cell Projection Organization GTP Binding Positive Regulation Of Cell Projection Organization Non-motile Cilium Actin Filament-based Process Molecular Adaptor Activity Regulation Of Anatomical Structure Morphogenesis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Actin Filament Polymerization Cytoskeletal Regulatory Protein Binding Histone H3K4 Dimethyltransferase Activity Histone H3K27 Dimethyltransferase Activity Cytoskeleton Regulation Of Cell Projection Assembly Response To Vitamin B2 C/EBP Complex Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Meiotic Metaphase Chromosome Alignment Thymidine Kinase Activity Endomembrane System Rho Protein Signal Transduction Regulation Of Cellular Component Size Actin Filament Organization Small GTPase-mediated Signal Transduction Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity CHOP-C/EBP Complex Regulation Of Stem Cell Proliferation Identical Protein Binding Regulation Of Developmental Process Cerebral Cortex Development Cerebellar Neuron Development Epithelial To Mesenchymal Transition	Nucleus Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Replicative Senescence Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process PML Body Euchromatin Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Chromatin Negative Regulation Of Biosynthetic Process Regulation Of Programmed Cell Death Negative Regulation Of Transcription By RNA Polymerase II Protein K63-linked Ubiquitination Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Protein Localization To Nucleus Cell Differentiation Chromosome, Telomeric Region Cellular Developmental Process Chromatin Remodeling DNA-binding Transcription Factor Activity Pexophagy Negative Regulation Of B Cell Proliferation