MAST2 and SLC34A1

Number of citations: 0 (PubMedID 11099500)
Data Source: HPRD (two hybrid)

		MAST2	SLC34A1
Name		microtubule associated serine/threonine kinase 2	solute carrier family 34 member 1
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane	Nucleoplasm Endosome Cytosol Plasma Membrane Brush Border Cell Surface Membrane Apical Plasma Membrane Nuclear Speck Brush Border Membrane Vesicle Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity	Sodium:phosphate Symporter Activity Protein Binding Symporter Activity PDZ Domain Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Protein Phosphorylation Cytoskeleton Organization Regulation Of Interleukin-12 Production Intracellular Signal Transduction Spermatid Differentiation	Ossification Kidney Development Monoatomic Ion Transport Sodium Ion Transport Phosphate Ion Transport Response To Nutrient Glycoprotein Metabolic Process Response To Xenobiotic Stimulus Response To Lead Ion Cellular Response To Phosphate Starvation Intracellular Phosphate Ion Homeostasis Response To Magnesium Ion Response To Estradiol Response To Vitamin A Phosphate Ion Transmembrane Transport Response To Potassium Ion Indole Metabolic Process Response To Peptide Hormone Sodium-dependent Phosphate Transport Positive Regulation Of Membrane Potential Response To Cadmium Ion Response To Mercury Ion Phosphate Ion Homeostasis Response To Growth Hormone Response To Parathyroid Hormone Cellular Response To Metal Ion Cellular Response To Parathyroid Hormone Stimulus Tricarboxylic Acid Metabolic Process Cellular Response To Staurosporine Response To Thyroid Hormone Dentinogenesis Sodium Ion Import Across Plasma Membrane Gentamycin Metabolic Process Response To Peptide Arsenate Ion Transmembrane Transport Positive Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Phosphate Transmembrane Transport
Pathways		None	Type II Na+/Pi cotransporters Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) Surfactant metabolism
Diseases		None	Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS		Body mass index ( 25673413 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Granulocyte count ( 27863252 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Iron status biomarkers (total iron binding capacity) ( 28334935 ) Iron status biomarkers (transferrin saturation) ( 28334935 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 ) Red blood cell count ( 27863252 32888494 ) Reticulocyte count ( 32888494 27863252 ) Serum metabolite levels ( 33031748 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Sum basophil neutrophil counts ( 27863252 ) Type 2 diabetes ( 32499647 )	Activated partial thromboplastin time ( 22703881 ) Asthma ( 32296059 ) Calcium levels ( 24068962 ) Chronic kidney disease ( 31152163 20383146 26831199 ) Creatinine levels ( 28270201 31015462 29403010 ) Estimated glomerular filtration rate ( 31451708 31152163 30604766 31015462 ) Estimated glomerular filtration rate in diabetes ( 31451708 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Glomerular filtration rate ( 27588450 29403010 ) Glomerular filtration rate (creatinine) ( 26831199 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Hematocrit ( 29403010 ) Inflammatory bowel disease ( 28067908 ) Kidney stones ( 31729369 26272126 ) Nephrolithiasis ( 22396660 ) Phosphorus levels ( 29403010 ) Red blood cell count ( 29403010 ) Serum parathyroid hormone levels ( 27927781 ) Ulcerative colitis ( 28067908 ) Urinary electrolytes (magnesium/calcium ratio) ( 27915449 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		27 interacting genes: ACE2 ACTN2 APP CDHR2 DYNLL1 MXRA7 PTEN RPS27A RPS6KA1 SH3GL2 SLC34A1 SLC9A3 SMN1 SNTB2 SRPK2 STK36 SUMO2 TK1 TPM1 TPM2 TPM3 TRAF2 TRAF6 TTN USP7 VANGL2 ZNF417	11 interacting genes: BSPRY FHL2 HPCAL1 HSP90AA1 HSP90AB1 MAST2 NHERF1 NHERF2 PDZK1 PEX19 YIF1A
Entrez ID		23139	6569
HPRD ID		11294	08918
Ensembl ID		ENSG00000086015	ENSG00000131183
Uniprot IDs		A0A669KBJ4 Q6P0Q8	Q06495 Q7Z725 Q86VN6
PDB IDs		2KQF 2KYL	Not available
GO Terms Enriched among Interactors		Muscle Thin Filament Tropomyosin Identical Protein Binding Structural Constituent Of Muscle Brush Border Membrane Actin Filament Actin Filament Binding Cellular Component Assembly Cytosol Apical Plasma Membrane Sarcomere Organization Enzyme Binding Muscle System Process Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Actin Cytoskeleton CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Negative Regulation Of Smooth Muscle Cell Proliferation Brush Border CD40 Receptor Complex TORC1 Signaling Positive Regulation Of JUN Kinase Activity Organelle Assembly Cytoskeletal Protein Binding Regulation Of Transport Regulation Of Biological Quality Protein Tag Activity Muscle Tissue Morphogenesis Muscle Filament Sliding Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Intracellular Signal Transduction Postsynaptic Actin Cytoskeleton Organization Actin-myosin Filament Sliding PDZ Domain Binding TOR Signaling Muscle Contraction Stress Fiber Actin Binding Response To Lead Ion Membrane Raft Postsynaptic Cytoskeleton Organization Presynapse System Process Sodium Ion Import Across Plasma Membrane Cardiac Muscle Hypertrophy Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Localization Protein Metabolic Process Cytoplasmic Side Of Plasma Membrane PML Body	Brush Border Membrane Type 2 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Type 3 Metabotropic Glutamate Receptor Binding Phosphatase Binding Telomerase Holoenzyme Complex Assembly Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Protein Localization To Membrane Apical Plasma Membrane Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Microvillus Membrane Cellular Localization Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex Protein Localization To Plasma Membrane ATP-dependent Protein Folding Chaperone Protein Folding Positive Regulation Of Nitric Oxide Biosynthetic Process Localization Within Membrane Positive Regulation Of Nitric Oxide Metabolic Process Intracellular Protein Localization Tau Protein Binding Protein Localization To Cell Periphery Protein Stabilization Cellular Response To Heat CTP Binding DATP Binding Protein Folding Chaperone Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Renal Phosphate Ion Absorption Regulation Of Nitric Oxide Biosynthetic Process Membrane Regulation Of Nitric Oxide Metabolic Process Atrial Cardiac Muscle Cell Development Regulation Of Cell Size Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex PDZ Domain Binding Peroxisome Membrane Targeting Sequence Binding