CUL9 and PLXNB3

Number of citations: 39 (PubMedID 12421765)
Data Source: HPRD (two hybrid)

		CUL9	PLXNB3
Name		cullin 9	plexin B3
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex	Semaphorin Receptor Complex Plasma Membrane Cell Surface Membrane
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding Rho GDP-dissociation Inhibitor Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Microtubule Cytoskeleton Organization Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Nuclear Division Protein Ubiquitination	Positive Regulation Of Endothelial Cell Proliferation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Nervous System Development Synapse Assembly Regulation Of Cell Shape Negative Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Negative Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Positive Chemotaxis Cell Chemotaxis Semaphorin-plexin Signaling Pathway
Pathways		Neddylation	Other semaphorin interactions
GWAS		Adult hearing difficulty ( 31564434 ) General risk tolerance (MTAG) ( 30643258 ) Obesity-related traits ( 23251661 ) Tea consumption ( 31046077 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	No GWAS studies recorded
Interacting Genes		9 interacting genes: CYCS DSCAM MTDH PLXNB3 TP53 UBE2E2 UBE2G1 UBE2G2 UBE2L3	10 interacting genes: ARHGEF11 BTBD3 CUL7 CUL9 DSCR9 HSPA13 MAGI2 MAGI3 RIT2 SPOCK2
Entrez ID		23113	5365
HPRD ID		06317	02198
Ensembl ID		ENSG00000112659	ENSG00000198753
Uniprot IDs		Q8IWT3	A8K920 Q9ULL4
PDB IDs		2JUF 8Q7E 8Q7H 8RHZ	Not available
GO Terms Enriched among Interactors		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Cell-cell Adhesion Mediator Activity Protein K11-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Post-translational Protein Modification Positive Regulation Of Axonogenesis Regulation Of Neurogenesis Protein K63-linked Ubiquitination Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Synapse Assembly Regulation Of Nervous System Development Rho GDP-dissociation Inhibitor Binding Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Apoptosome Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Positive Regulation Of Thymocyte Apoptotic Process Response To Actinomycin D T Cell Proliferation Involved In Immune Response ISG15 Transferase Activity Positive Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Axonogenesis Central Nervous System Development Negative Regulation Of Catalytic Activity Negative Regulation Of Lamellipodium Assembly Histone Deacetylase Regulator Activity Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of G1/S Transition Of Mitotic Cell Cycle B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Regulation Of G1 To G0 Transition Glial Cell Apoptotic Process Cellular Response To UV-C ATP-dependent DNA/DNA Annealing Activity	Cullin-RING Ubiquitin Ligase Complex