PEG10 and SIAH2

Number of citations: 0 (PubMedID 12810624)
Data Source: HPRD (two hybrid, in vitro)

		PEG10	SIAH2
Name		paternally expressed 10	siah E3 ubiquitin protein ligase 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Vesicle	Nucleus Nucleoplasm Cytoplasm Early Endosome Cytosol Neuronal Cell Body
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Apoptotic Process Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MRNA Transport Protein Homooligomerization Viral Translational Frameshifting Vesicle-mediated Intercellular Transport	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Small GTPase-mediated Signal Transduction Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Rhythmic Process Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		None	Netrin-1 signaling Ub-specific processing proteases Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
GWAS		No GWAS studies recorded	BRCA1/2-negative high-risk breast cancer ( 30323354 ) Breast cancer ( 22951594 31757997 )
Interacting Genes		21 interacting genes: CALCOCO2 CLIP4 EXOSC5 LAMTOR5 LNX2 MAPT NXF1 RAB3IP RBFOX2 RNF181 RTL8A RTL8B SIAH1 SIAH2 SMCHD1 SNRPA SNW1 TOLLIP UBC VPS26C ZNF512B	46 interacting genes: AFF1 AKR1C3 ATN1 CACYBP CCAR2 CCBE1 CHEK2 DCC DLST DYRK2 EEF1D EGLN3 HIPK2 HIPK3 LATS2 MYD88 NRF1 OPRM1 PEG10 PEG3 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 UBE2N UBE2V2 USP13 USP19 VAV1
Entrez ID		23089	6478
HPRD ID		15117	03737
Ensembl ID		ENSG00000242265	ENSG00000181788
Uniprot IDs		A0A087WZG9 Q86TG7	O43255
PDB IDs		7LGA	5H9M
GO Terms Enriched among Interactors		Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding	Cell Death Nucleoplasm Apoptotic Process Programmed Cell Death Nucleus Regulation Of Primary Metabolic Process Protein Modification Process Post-translational Protein Modification Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process SUMO Transferase Activity Positive Regulation Of Metabolic Process Cellular Response To Stress Protein Metabolic Process PML Body Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Macromolecule Metabolic Process Transferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of RNA Metabolic Process Cytosol Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling DNA Damage Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process Intrinsic Apoptotic Signaling Pathway Signal Transduction By P53 Class Mediator Proteolysis Involved In Protein Catabolic Process Protein Sumoylation Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Macromolecule Catabolic Process Negative Regulation Of Macromolecule Metabolic Process