WDTC1 and MED23

Number of citations: 39 (PubMedID 12421765)
Data Source: HPRD (two hybrid)

		WDTC1	MED23
Name		WD and tetratricopeptide repeats 1	mediator complex subunit 23
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm Transcription Regulator Complex Mediator Complex Core Mediator Complex
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Histone Binding Histone Deacetylase Binding	Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Glucose Metabolic Process Regulation Of Cell Size Protein Ubiquitination Cellular Response To Insulin Stimulus Multicellular Organism Growth Negative Regulation Of Fatty Acid Biosynthetic Process Intracellular Chemical Homeostasis	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of T Cell Extravasation
Pathways		Neddylation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
GWAS		No GWAS studies recorded	L-arginine levels ( 25245031 ) Type 2 diabetes ( 30054458 )
Interacting Genes		3 interacting genes: DDB1 MED23 MED4	17 interacting genes: CEBPA CEBPB CTDP1 ELF3 ESR1 ESR2 ETS1 FOXJ3 MED13 MED9 NCOA6 PUM2 RELA SREBF1 VDR WDTC1 WEE2-AS1
Entrez ID		23038	9439
HPRD ID		10307	05436
Ensembl ID		ENSG00000142784	ENSG00000112282
Uniprot IDs		Q8N5D0	Q05DL5 Q9ULK4
PDB IDs		3I7N	6H02 7EMF 7ENA 7ENC 7ENJ 7LBM 8GXQ 8GXS 8T9D 8TQW 8TRH
GO Terms Enriched among Interactors		Positive Regulation Of DNA-templated Transcription, Elongation Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Mediator Complex Core Mediator Complex Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Protein-DNA Complex Assembly Positive Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of T Cell Extravasation Base-excision Repair, AP Site Formation Via Deaminated Base Removal WD40-repeat Domain Binding Cul4B-RING E3 Ubiquitin Ligase Complex Transcription Coactivator Activity Ubiquitin Ligase Complex Scaffold Activity Nucleic Acid Metabolic Process UV-damage Excision Repair Spindle Assembly Involved In Female Meiosis Cul4A-RING E3 Ubiquitin Ligase Complex Base-excision Repair, AP Site Formation Meiotic Spindle Assembly Cellular Component Assembly Epigenetic Programming In The Zygotic Pronuclei Positive Regulation Of Cellular Extravasation Nuclear Vitamin D Receptor Binding Ectopic Germ Cell Programmed Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Programmed Cell Death Involved In Cell Development Meiotic Spindle Organization Positive Regulation Of Gluconeogenesis Cullin Family Protein Binding Cul4-RING E3 Ubiquitin Ligase Complex Viral Release From Host Cell Nuclear Thyroid Hormone Receptor Binding Positive Regulation Of Viral Genome Replication Epigenetic Programming Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Migration Regulation Of Cellular Extravasation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Lymphocyte Migration Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Metabolic Process	Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Nuclear Receptor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process C/EBP Complex Regulation Of MiRNA Transcription Nucleoplasm Nuclear Steroid Receptor Activity Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway CHOP-C/EBP Complex RNA Metabolic Process Macromolecule Biosynthetic Process Nuclear Estrogen Receptor Activity Mammary Gland Branching Involved In Pregnancy Chromatin Binding Histone Deacetylase Binding Response To Lipid Negative Regulation Of Macromolecule Metabolic Process