SNRNP200 and BARD1

Number of citations: 93 (PubMedID 22990118)
Data Source: BioGRID (two hybrid)

		SNRNP200	BARD1
Name		small nuclear ribonucleoprotein U5 subunit 200	BRCA1 associated RING domain 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Plasma Membrane Cilium Membrane Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Nuclear Speck BRCA1-BARD1 Complex Cytoplasmic Ribonucleoprotein Granule BRCA1-A Complex BRCA1-B Complex BRCA1-C Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Kinase Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin-modified Histone Reader Activity Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity
	Biological Process	Cis Assembly Of Pre-catalytic Spliceosome Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) MRNA Splicing, Via Spliceosome Osteoblast Differentiation MRNA Processing RNA Splicing	Tissue Homeostasis DNA Repair Regulation Of DNA Repair Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Damage Response Protein Ubiquitination Negative Regulation Of MRNA 3'-end Processing Homologous Recombination Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Mitotic G2/M Transition Checkpoint Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Protein Export From Nucleus Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Protein K6-linked Ubiquitination DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Damage Checkpoint
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) UCH proteinases Metalloprotease DUBs Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective DNA double strand break response due to BRCA1 loss of function Defective DNA double strand break response due to BARD1 loss of function Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Diseases		Retinitis pigmentosa (RP)	None
GWAS		No GWAS studies recorded	Feeling fed-up ( 29500382 ) General risk tolerance (MTAG) ( 30643258 ) Neuroblastoma ( 21124317 22941191 ) Neuroblastoma (high-risk) ( 19412175 ) Neuroblastoma (MYCN amplification) ( 28924153 ) Neurociticism ( 29500382 ) Sporadic neuroblastoma ( 28545128 )
Interacting Genes		33 interacting genes: APC BARD1 BCAS2 BRCA1 CEBPA CHMP1B CREBBP DHX38 DUX4 ECT2 ERG GNMT GRB2 HSPB1 LCOR LSM8 MEGF10 PIN1 PRPF3 PRPF31 PRPF6 PTEN RNF10 RNF113A SF3B3 SMNDC1 SUMO2 UBE2I USP19 USP7 VHL YWHAB YWHAG	131 interacting genes: ACP1 AKIP1 AP1B1 ASH2L ATP1B1 ATP1B3 AXIN2 BCCIP BCL3 BGLT3 BRCA1 BRD7 CAP1 CBX1 CBX3 CBX5 CCDC136 CDK1 CDK2 CEP70 CHD3 CNTN4 COL1A1 COMMD1 CSTF1 DCAF8L2 DCC DDX39B DNAI7 ELP1 ESR1 EWSR1 EXOC5 FAM9B FEZ1 FKBP1A FKBP2 FKBP3 FUCA1 GIT1 GOLGA2 GPRASP2 H2AC20 H2AC4 H2BC3 H3C1 HAP1 HNRNPC HNRNPLL HSF2BP HSPA14 IDI1 IKZF1 ING5 KAT5 KAT7 KBTBD7 KIFC3 KRT40 LARP7 LDOC1 LGALS8 LRIF1 MACROH2A1 MAGED1 MDC1 MRPS22 MSH2 MSH3 MSH6 MT-ND1 MT2A MTUS2 NFKB1 NFKBIA NPC2 PCBP2 PDXK PDZD8 PIAS1 PIAS4 PIN1 POLR2A POLR2H POMZP3 POU2F1 PSMA7 PTN RABEP1 RAD51 RBBP8 RBMY2BP RNF10 RPS20 SELENBP1 SETDB1 SKIC8 SMCHD1 SNRNP200 SNX3 SPAG5 SRSF2 TCERG1 TERF2 TMEM248 TOP1 TP53 TRAF1 TRAPPC11 TRAPPC8 TULP2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBE2U UBE2W UBE3A UBR5 UBXN1 WRN XRCC6 ZFP64 ZHX1 ZNF121 ZNF655
Entrez ID		23020	580
HPRD ID		03391	03354
Ensembl ID		ENSG00000144028	ENSG00000138376
Uniprot IDs		O75643	A0A087WZ19 A0AVN2 C9IYG1 F6MDI0 F6MDI1 F6MDI2 Q99728
PDB IDs		2Q0Z 3JCR 4F91 4F92 4F93 4KIT 5O9Z 5URJ 5URK 5URM 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6QDV 6QW6 6QX9 6S8O 6S8Q 6S9I 7A5P 7ABG 7ABI 7BDI 7BDJ 7BDK 7BDL 7DVQ 7OS1 7OS2 7PX3 7W5B 8BC8 8BC9 8BCA 8BCB 8BCC 8BCD 8BCE 8BCF 8BCG 8BCH 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8I0P 8I0R 8I0S 8I0T 8I0W 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP9 8QPA 8QPB 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8Y6O 9FMD	1JM7 2NTE 2R1Z 3C5R 3FA2 6M14 7E8I 7JZV 7LYB 7LYC 8GRQ
GO Terms Enriched among Interactors		Nucleoplasm Spliceosomal Complex RNA Splicing, Via Transesterification Reactions U2-type Precatalytic Spliceosome Nucleus Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing MRNA Processing Post-translational Protein Modification Protein Stabilization Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Protein Modification Process U4/U6 X U5 Tri-snRNP Complex Regulation Of Primary Metabolic Process Nuclear Speck MRNA Metabolic Process RNA Binding Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Protein Modification By Small Protein Conjugation Spliceosomal Tri-snRNP Complex Assembly Protein Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Protein Stability Regulation Of Cell Cycle Process Nucleic Acid Metabolic Process Regulation Of Metabolic Process Protein Kinase C Inhibitor Activity Cellular Response To Ionizing Radiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Protein K6-linked Ubiquitination Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Cellular Response To Radiation Regulation Of Cell Cycle BRCA1-B Complex Postsynaptic Cytosol U2-type Spliceosomal Complex RNA Processing Catalytic Step 2 Spliceosome	DNA Damage Response Nucleoplasm DNA Repair Ubiquitin Conjugating Enzyme Activity DNA Metabolic Process Chromosome Nucleus Chromatin Organization Nucleic Acid Metabolic Process Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Protein Polyubiquitination Protein K48-linked Ubiquitination Double-strand Break Repair Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Enzyme Binding Modification-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA Metabolic Process Ubiquitin Protein Ligase Binding Post-translational Protein Modification Maintenance Of DNA Repeat Elements Heterochromatin Formation Negative Regulation Of DNA Recombination Chromatin Binding Protein Monoubiquitination Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Single Guanine Insertion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Gene Expression, Epigenetic