DAAM1 and B3GALT4

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		DAAM1	B3GALT4
Name		dishevelled associated activator of morphogenesis 1	beta-1,3-galactosyltransferase 4
Structure			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Motile Cilium Ciliary Basal Body Cell Projection Synapse Perinuclear Region Of Cytoplasm Presynapse Glutamatergic Synapse	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding Identical Protein Binding	N-acetyl-beta-D-glucosaminide Beta-(1,3)-galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity Ganglioside Galactosyltransferase Activity
	Biological Process	Wnt Signaling Pathway Actin Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Presynaptic Actin Cytoskeleton Organization	Ganglioside Biosynthetic Process Protein Glycosylation Protein O-linked Glycosylation Lipid Metabolic Process Glycosphingolipid Biosynthetic Process Oligosaccharide Biosynthetic Process Carbohydrate Derivative Biosynthetic Process
Pathways		PCP/CE pathway RHO GTPases Activate Formins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle	Lewis blood group biosynthesis Glycosphingolipid biosynthesis
GWAS		Brain morphology (MOSTest) ( 32665545 ) Cortical surface area ( 32963231 ) Cortical surface area (visual PC2) ( 32198502 ) Cortical thickness ( 32963231 ) Cortical volume ( 32963231 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Inferior temporal gyrus volume ( 31530798 ) Left–right brain asymmetry ( 33723403 ) Occipital lobe volume ( 31396565 ) Optic disc size ( 31809533 ) Parietal lobe volume ( 31396565 ) Parkinsonism in frontotemporal lobe dementia ( 29724592 ) Type 2 diabetes ( 25483131 )	Autism spectrum disorder or schizophrenia ( 28540026 ) Body mass index ( 26426971 ) LDL cholesterol ( 18193043 )
Interacting Genes		7 interacting genes: AMBP B3GALT4 DVL1 DVL2 PRPF40A RHOA USP10	5 interacting genes: DAAM1 DDX19B DYNLL1 METTL18 NOTCH1
Entrez ID		23002	8705
HPRD ID		09433	04370
Ensembl ID		ENSG00000100592	ENSG00000235863
Uniprot IDs		Q9Y4D1	B3KQP5 O96024 Q5STJ7
PDB IDs		2J1D 2Z6E	Not available
GO Terms Enriched among Interactors		Wnt Signaling Pathway, Planar Cell Polarity Pathway Convergent Extension Involved In Neural Plate Elongation Non-canonical Wnt Signaling Pathway Convergent Extension Involved In Organogenesis Convergent Extension Involved In Gastrulation Positive Regulation Of Neuron Projection Arborization Epithelial Tube Morphogenesis Convergent Extension Regulation Of Neuron Projection Arborization Cochlea Morphogenesis Frizzled Binding Regulation Of Cell Morphogenesis Wnt Signaling Pathway Cytochrome C Metabolic Process Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cytoplasmic Microtubule Organization Tube Morphogenesis Mitotic Cleavage Furrow Formation Morphogenesis Of An Epithelium Outflow Tract Morphogenesis Lateral Plasma Membrane Heart Looping Embryonic Heart Tube Morphogenesis Ganglioside Galactosyltransferase Activity Clathrin-coated Vesicle Calcium Oxalate Binding Aortic Valve Formation Protein Kinase Binding Positive Regulation Of Vascular Associated Smooth Muscle Contraction Tissue Morphogenesis Endothelial Tube Lumen Extension Skeletal Muscle Satellite Cell Migration Regulation Of Cytokinesis Positive Regulation Of Protein Localization To Presynapse Canonical Wnt Signaling Pathway Negative Regulation Of Stress Granule Assembly Collagen Fibril Binding IgA Binding Beta Selection Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor Cytochrome Metabolic Process Bone Trabecula Morphogenesis Regulation Of JNK Cascade Dendritic Spine Apolipoprotein A-I-mediated Signaling Pathway Roundabout Signaling Pathway Matrix Side Of Mitochondrial Inner Membrane Organelle Organization Regulation Of Cell Division Regulation Of Systemic Arterial Blood Pressure By Endothelin	MAML1-RBP-Jkappa- ICN1 Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Vasculogenesis Involved In Coronary Vascular Morphogenesis Venous Endothelial Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Distal Tubule Development Auditory Receptor Cell Fate Commitment Notch Signaling Involved In Heart Development Regulation Of Aorta Morphogenesis Growth Involved In Heart Morphogenesis Negative Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Epidermal Cell Fate Specification Endocardium Morphogenesis Coronary Sinus Valve Morphogenesis Retinal Cone Cell Differentiation Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Pro-B Cell Differentiation Cardiac Right Ventricle Formation Glomerular Mesangial Cell Development Enzyme Inhibitor Activity Cell Migration Involved In Endocardial Cushion Formation Chemical Synaptic Transmission, Postsynaptic Foregut Morphogenesis Compartment Pattern Specification Mitral Valve Formation Arterial Endothelial Cell Differentiation Cellular Response To Tumor Cell Regulation Of Cell Adhesion Involved In Heart Morphogenesis Cardiac Vascular Smooth Muscle Cell Development Negative Regulation Of Extracellular Matrix Constituent Secretion Positive Regulation Of Aorta Morphogenesis Coronary Vein Morphogenesis Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cardiac Right Atrium Morphogenesis Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Protein-L-histidine N-tele-methyltransferase Activity Cell Surface Receptor Signaling Pathway Involved In Heart Development Negative Regulation Of Endothelial Cell Chemotaxis Mesangial Cell Development Luteolysis Endocardium Development Cardiac Atrium Morphogenesis T-helper 17 Type Immune Response Endocardial Cell Differentiation