ACIN1 and PAFAH1B2

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		ACIN1	PAFAH1B2
Name		apoptotic chromatin condensation inducer 1	platelet activating factor acetylhydrolase 1b catalytic subunit 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Nuclear Speck Nuclear Lumen Exon-exon Junction Complex ASAP Complex	Fibrillar Center Extracellular Region Nucleolus Cytoplasm Cytosol Plasma Membrane 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding ATP Hydrolysis Activity Enzyme Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity
	Biological Process	MRNA Processing Apoptotic Process RNA Splicing Erythrocyte Differentiation Apoptotic Chromosome Condensation Positive Regulation Of Apoptotic Process Positive Regulation Of Monocyte Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome	Lipid Metabolic Process Spermatogenesis Lipid Catabolic Process Positive Regulation Of Macroautophagy
Pathways		Apoptotic cleavage of cellular proteins mRNA Splicing - Major Pathway	Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic
GWAS		No GWAS studies recorded	Adult body size ( 32376654 ) Blood protein levels ( 23696881 ) HDL cholesterol ( 24507774 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Protein quantitative trait loci ( 18464913 ) Refractive error ( 32231278 ) Systolic blood pressure ( 30578418 )
Interacting Genes		13 interacting genes: ABCF3 AKR1C3 BTBD10 CASP3 CSNK2A1 KLHL26 LINC01554 PAFAH1B2 PCBD1 RNF10 SRPK2 SUMO2 YWHAG	19 interacting genes: ACIN1 ASF1A CCT3 CLVS2 CRK PAFAH1B1 PAFAH1B3 PINX1 PPP1R12C PRKN REXO1 RPLP0 SLA SNUPN STAT3 TIMM50 TRIM55 TRIM63 ZFP36L1
Entrez ID		22985	5049
HPRD ID		05191	03940
Ensembl ID		ENSG00000100813	ENSG00000168092
Uniprot IDs		B4DQZ7 E7EQT4 Q9UKV3 S4R3H4	P68402 V9HW44
PDB IDs		6G6S	1VYH
GO Terms Enriched among Interactors		Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Positive Regulation Of Neuron Apoptotic Process Protein Catabolic Process Positive Regulation Of Metabolic Process Anterior Neural Tube Closure Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Epidermal Cell Differentiation Cellular Response To Staurosporine Regulation Of Protein Stability Keratinocyte Differentiation Execution Phase Of Apoptosis Phospholipase A2 Activator Activity Regulation Of Macroautophagy Regulation Of Autophagy Catabolic Process Regulation Of Translational Initiation Protein Localization To Vacuole Positive Regulation Of Macroautophagy Protein Kinase CK2 Complex Negative Regulation Of Translational Initiation Symbiont-mediated Disruption Of Host Cell PML Body PML Body Platelet-activating Factor Acetyltransferase Activity 1-alkyl-2-acetylglycerophosphocholine Esterase Complex 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Presynapse Nuclear Speck Organization Protein Kinase C Inhibitor Activity Ketosteroid Monooxygenase Activity Polyprenol Catabolic Process Negative Regulation Of Retinoic Acid Biosynthetic Process Delta4-3-oxosteroid 5beta-reductase Activity Geranylgeranyl Reductase Activity 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity Ketoreductase Activity Prostaglandin D2 11-ketoreductase Activity Prostaglandin H2 Endoperoxidase Reductase Activity Prostaglandin F Synthase Activity Farnesol Catabolic Process Cellular Response To Jasmonic Acid Stimulus Regulation Of Isoprenoid Metabolic Process Sesquiterpenoid Metabolic Process Luteolysis Glial Cell Apoptotic Process Positive Regulation Of Aggrephagy 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity	1-alkyl-2-acetylglycerophosphocholine Esterase Complex Positive Regulation Of Monocyte Differentiation Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Diapedesis Reelin-mediated Signaling Pathway Protein Localization To Organelle Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Monocyte Differentiation Regulation Of ATP Biosynthetic Process Negative Regulation Of Glycolytic Process Positive Regulation Of Myeloid Cell Differentiation Phospholipase Binding Negative Regulation Of ATP Metabolic Process Response To Glucocorticoid Intracellular Protein Localization Response To Hormone Microtubule Nucleus Regulation Of JNK Cascade Protein-containing Complex Binding Response To Corticosteroid Negative Regulation Of JNK Cascade Positive Regulation Of Cell Growth Positive Regulation Of ATP Metabolic Process Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Protein Localization To Mitochondrion Regulation Of Reactive Oxygen Species Biosynthetic Process RNA Binding Cell Population Proliferation Organelle Organization Negative Regulation Of Spontaneous Neurotransmitter Secretion Protein Localization To Nucleus Regulation Of Telomere Maintenance Via Telomerase Phosphotyrosine Residue Binding Regulation Of Myeloid Cell Differentiation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Cellular Response To Raffinose Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Erythrocyte Differentiation Response To Steroid Hormone Helper T Cell Diapedesis Leukocyte Migration Positive Regulation Of Protein Localization Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin