PAXIP1 and HSPA4L

Number of citations: 93 (PubMedID 22990118)
Data Source: BioGRID (two hybrid)

		PAXIP1	HSPA4L
Name		PAX interacting protein 1	heat shock protein family A (Hsp70) member 4 like
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Matrix Histone Methyltransferase Complex MLL3/4 Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity ATP Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Vasculogenesis DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell Migration Positive Regulation Of Isotype Switching Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Transcription Initiation By RNA Polymerase II Adipose Tissue Development Chorion Development Regulation Of Cell Cycle G2/M Phase Transition	Protein Folding Response To Unfolded Protein
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ) Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Regulation of HSF1-mediated heat shock response
GWAS		Bladder cancer (smoking interaction) ( 24662972 ) Metabolite levels ( 23823483 )	High light scatter reticulocyte percentage of red cells ( 32888494 ) Major depressive disorder ( 29317602 )
Interacting Genes		90 interacting genes: A2M APP ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CIAO2B CLU COMTD1 CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FBLN5 FUCA1 H2AX H3C1 HNRNPLL HSPA14 HSPA4L INTS7 LACTB MAPRE2 MAST1 MRPL33 MT-ND1 MT2A MTIF3 MTNR1A NOS3 NPC2 NUPR1 PAGR1 PAX2 PCBP2 PCYT1B PGGHG PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELENOV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 XAGE1B ZBTB8A ZNF251 ZNF280B	5 interacting genes: MSRA NEDD8 PAXIP1 PHLDA1 PTEN
Entrez ID		22976	22824
HPRD ID		08491	07137
Ensembl ID		ENSG00000157212	ENSG00000164070
Uniprot IDs		Q6ZW49	A0A140VKE7 B4DXT2 B4DZR0 E9PDE8 O95757
PDB IDs		3SQD	Not available
GO Terms Enriched among Interactors		Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cytoplasm Protein-DNA Complex	Nucleoplasm L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Chorion Development Cellular Response To Camptothecin Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Protein Repair Regulation Of Cell Junction Assembly Locomotor Rhythm Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Specialization Assembly Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Presynaptic Membrane Organization Schmidt-Lanterman Incisure Anaphase-promoting Complex Binding Postsynaptic Density Assembly Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly MLL3/4 Complex Positive Regulation Of Isotype Switching To IgG Isotypes Methionine Metabolic Process Regulation Of Proteolysis Protein Tag Activity Phosphatidylinositol-3-phosphate Phosphatase Activity Prepulse Inhibition Meiotic Spindle Assembly Synapse Maturation Maternal Behavior Myelin Maintenance Negative Regulation Of Epithelial Cell Migration Parental Behavior Regulation Of Isotype Switching To IgG Isotypes Dendritic Spine Morphogenesis