MMRN1 and F5

Number of citations: 0 (PubMedID 15452129)
Data Source: HPRD (in vitro)

		MMRN1	F5
Name		multimerin 1	coagulation factor V
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Multimerin Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Vesicle
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Copper Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Cell Adhesion Blood Coagulation Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Adhesion Mediated By Integrin Negative Regulation Of Wound Healing Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Platelet Aggregation	Blood Coagulation Hemostasis Blood Circulation Response To Vitamin K
Pathways		Platelet degranulation O-linked glycosylation	Platelet degranulation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation
Drugs		None	Drotrecogin alfa Thrombomodulin Alfa Thrombin Protein C Human thrombin Thrombin alfa Protein S human Anti-inhibitor coagulant complex
Diseases		None	Factor V deficiency; Owren disease Inherited thrombophilia
GWAS		Appendicular lean mass ( 33097823 ) Bitter alcoholic beverage consumption ( 31046077 ) Parkinson's disease ( 19915575 )	Activated partial thromboplastin time ( 22703881 29403010 ) Cytokine network levels (multivariate analysis) ( 31679650 ) D-dimer levels ( 21502573 ) D-dimer levels in HIV infection ( 33095540 ) Hemostatic factors and hematological phenotypes ( 22443383 ) Hippocampal atrophy ( 22745009 ) Inflammatory biomarkers (multivariate analysis) ( 33110245 ) Iron status biomarkers (ferritin levels) ( 33536631 ) Iron status biomarkers (total iron binding capacity) ( 33536631 ) Ischemic stroke ( 26732560 ) Macrovascular complications in type 2 diabetes ( 33430853 ) Medication use (antithrombotic agents) ( 31015401 ) Optic disc area ( 31798171 25631615 ) Optic disc size ( 31809533 ) Peripheral artery disease ( 31285632 ) Plasma factor V levels in venous thrombosis ( 31271701 ) Prothrombin time ( 29403010 ) Stem cell growth factor beta levels ( 27989323 ) Thrombosis ( 26908601 ) Uric acid levels ( 23703922 ) Venous thromboembolism ( 32232851 33592630 31676865 31420334 28373160 25772935 23650146 22672568 21980494 ) Vertical cup-disc ratio ( 31798171 28073927 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Interacting Genes		3 interacting genes: CDKN2A F5 SNCA	11 interacting genes: CALR CSNK2A1 CTSG ELANE F10 F2 MMRN1 PROC PROS1 SERPINA3 SRPK2
Entrez ID		22915	2153
HPRD ID		03267	01964
Ensembl ID		ENSG00000138722	ENSG00000198734
Uniprot IDs		E7EPG1 Q13201	P12259
PDB IDs		Not available	1CZS 1CZT 1CZV 3P6Z 3P70 3S9C 7KVE 7KVF 7KXY 7TPP 8FDG 8TN9 9CTH
GO Terms Enriched among Interactors		Amyloid Fibril Formation Protein Destabilization Copper Ion Binding Ligase Inhibitor Activity Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Cellular Response To Chemical Stress Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Senescence-associated Heterochromatin Focus Negative Regulation Of Immature T Cell Proliferation In Thymus Apoptotic Process Involved In Mammary Gland Involution Response To Vitamin K Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Serotonin Uptake Negative Regulation Of Immature T Cell Proliferation Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Ubiquitin Protein Ligase Activity Mitochondrial Depolarization Oncogene-induced Cell Senescence Regulation Of Protein Stability Positive Regulation Of Apoptotic Process Involved In Development Somatic Stem Cell Division Protein Localization To Nucleolus Negative Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Membrane Potential Negative Regulation Of Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization Response To Oxidative Stress Mitochondrial Matrix	Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Neutrophil-mediated Killing Of Bacterium Leukocyte Mediated Immunity Serine-type Endopeptidase Activity Regulation Of Platelet Activation Acute Inflammatory Response Negative Regulation Of Wound Healing Leukocyte Mediated Cytotoxicity Neutrophil Mediated Immunity Golgi Lumen Regulation Of Body Fluid Levels Killing By Host Of Symbiont Cells Extracellular Region Extracellular Space Calcium Ion Binding Biological Process Involved In Interaction With Symbiont Regulation Of Wound Healing External Side Of Plasma Membrane Neutrophil-mediated Killing Of Gram-negative Bacterium Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Immune Effector Process Regulation Of Response To Wounding Negative Regulation Of Coagulation Extracellular Matrix Cell Killing Peptidase Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Defense Response Positive Regulation Of Phagocytosis Azurophil Granule Lumen Positive Regulation Of Platelet Aggregation Endopeptidase Activity IgG Binding Regulation Of Multicellular Organismal Process Endoplasmic Reticulum Lumen Regulation Of Phagocytosis Acute Inflammatory Response To Antigenic Stimulus Response To Stress Response To Other Organism Positive Regulation Of Homotypic Cell-cell Adhesion Fibrinolysis Blood Microparticle Killing Of Cells Of Another Organism Negative Regulation Of Multicellular Organismal Process