CARD8 and NLRP2

Number of citations: 0 (PubMedID 15030775)
Data Source: HPRD (in vivo)

		CARD8	NLRP2
Name		caspase recruitment domain family member 8	NLR family pyrin domain containing 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Canonical Inflammasome Complex NLRP3 Inflammasome Complex CARD8 Inflammasome Complex	Chromosome, Telomeric Region Cytoplasm Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity NACHT Domain Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity CARD Domain Binding Cysteine-type Endopeptidase Activator Activity Molecular Condensate Scaffold Activity	Nucleotide Binding Protein Binding ATP Binding Pyrin Domain Binding
	Biological Process	Activation Of Innate Immune Response Immune System Process Proteolysis Inflammatory Response Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Inflammatory Response Protein Homooligomerization Protein Maturation Defense Response To Virus Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Self Proteolysis Antiviral Innate Immune Response CARD8 Inflammasome Complex Assembly Pyroptotic Cell Death Negative Regulation Of NLRP3 Inflammasome Complex Assembly	Immune System Process Apoptotic Process Inflammatory Response Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Innate Immune Response Regulation Of Inflammatory Response Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Formation of apoptosome Regulation of the apoptosome activity	None
GWAS		No GWAS studies recorded	Inflammatory bowel disease ( 23128233 ) Venous thromboembolism ( 31420334 )
Interacting Genes		9 interacting genes: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG MTDH NLRP2 NLRP3	4 interacting genes: APP CARD8 FAF1 PYDC2
Entrez ID		22900	55655
HPRD ID		16425	14805
Ensembl ID		ENSG00000105483	ENSG00000022556
Uniprot IDs		Q9Y2G2	A8K9G6 J3KN39 Q9NX02
PDB IDs		4IKM 6K9F 6XKJ 7JKQ 7JN7	9C6V 9C6W 9C6X
GO Terms Enriched among Interactors		Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Cysteine-type Endopeptidase Activity CARD Domain Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Protease Inhibitor Complex Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Negative Regulation Of Interleukin-1 Production Regulation Of Programmed Cell Death Regulation Of DNA-binding Transcription Factor Activity Inflammatory Response Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Interleukin-1 Production Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Regulation Of Intracellular Signal Transduction Response To Lipopolysaccharide Response To External Biotic Stimulus Positive Regulation Of Interleukin-18 Production Regulation Of Canonical NF-kappaB Signal Transduction Response To Molecule Of Bacterial Origin Protein-containing Complex Caspase Binding Regulation Of Interleukin-18 Production Canonical Inflammasome Complex Interleukin-18-mediated Signaling Pathway Regulation Of Cytokine Production Apoptotic Process Cell Death Programmed Cell Death Cellular Response To Lipid Identical Protein Binding Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Protein Binding Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Intracellular Signal Transduction Cysteine-type Endopeptidase Inhibitor Activity Regulation Of Signal Transduction Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Pyroptotic Inflammatory Response Regulation Of Gene Expression Regulation Of Protein Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Osmotic Stress Defense Response	Regulation Of Interleukin-1 Production Regulation Of Interleukin-1 Beta Production Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Inflammatory Response Negative Regulation Of Cell Communication Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Amyloid-beta Complex Innate Immune Response Growth Cone Lamellipodium Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction CARD8 Inflammasome Complex Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Defense Response To Symbiont Defense Response To Other Organism Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein-containing Complex Assembly Acetylcholine Receptor Activator Activity Regulation Of Defense Response Positive Regulation Of Apoptotic Signaling Pathway Lipoprotein Particle Regulation Of Cytokine Production Positive Regulation Of Protein Import NACHT Domain Binding PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Inflammatory Response Endosome To Plasma Membrane Transport Vesicle Programmed Cell Death Positive Regulation Of Endothelin Production Growth Cone Filopodium Cell Death Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development