ARHGEF15 and CSTPP1

Number of citations: 0 (PubMedID 16189514)
Data Source: HPRD (two hybrid)

		ARHGEF15	CSTPP1
Name		Rho guanine nucleotide exchange factor 15	centriolar satellite-associated tubulin polyglutamylase complex regulator 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Dendrite Cell Projection Postsynapse Glutamatergic Synapse	Cytoplasm Cytoskeleton Microtubule Centriolar Satellite
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Regulation Of Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Retina Vasculature Morphogenesis In Camera-type Eye Regulation Of Postsynapse Assembly Negative Regulation Of Synapse Maturation	Microtubule Cytoskeleton Organization Microtubule Polymerization Cilium Disassembly Regulation Of Protein Complex Stability
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	None
GWAS		Bipolar disorder ( 28115744 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Immature fraction of reticulocytes ( 32888494 ) LDL cholesterol ( 30275531 ) Platelet distribution width ( 32888494 ) Total cholesterol levels ( 30275531 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	No GWAS studies recorded
Interacting Genes		14 interacting genes: CDC42 CEP55 CSTPP1 DNAJC5 EPHA4 ESR1 ESRRG GORASP2 LASP1 MOB4 PIN1 PRKG1 RHOA SH3RF1	19 interacting genes: ARHGEF15 CDC16 ENY2 FH GCA GSR PHF1 PNMA5 PRKAR1A PSMA1 RAB17 RAB29 RBM48 RPL8 RPS3A TXN2 UBE3A UBQLN4 ZFHX3
Entrez ID		22899	79096
HPRD ID		10535	08332
Ensembl ID		ENSG00000198844	ENSG00000149179
Uniprot IDs		A0A0S2Z547 O94989	B4DUV7 Q9H6J7
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Postsynapse Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Midbody Steroid Hormone Receptor Signaling Pathway Estrogen Response Element Binding Regulation Of Intracellular Signal Transduction Regulation Of Cytokinesis Glutamatergic Synapse Nuclear Receptor-mediated Signaling Pathway Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Negative Regulation Of Locomotion Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Modification Of Synaptic Structure Polarized Epithelial Cell Differentiation Negative Regulation Of Cell Motility Nuclear Steroid Receptor Activity Microtubule Polymerization Hormone-mediated Signaling Pathway Mitotic Cytokinetic Process Neuron Migration Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Establishment Of Epithelial Cell Polarity Steroid Binding Organelle Organization Negative Regulation Of Neuron Apoptotic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Division Cell-cell Junction Organization Negative Regulation Of Apoptotic Process Cytokinetic Process Intracellular Signaling Cassette Cell Junction Organization Microtubule Polymerization Or Depolymerization Negative Regulation Of Signal Transduction Cell Migration Negative Regulation Of Programmed Cell Death Supramolecular Fiber Organization Positive Regulation Of Cytokinesis Substantia Nigra Development Regulation Of Amyloid-beta Formation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Intracellular Receptor Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Stress Fiber Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Mitotic Cleavage Furrow Formation Cytoplasm	None