NLRP1 and CASP5

Number of citations: 0 (PubMedID 12191486)
Data Source: HPRD (in vitro, in vivo)

		NLRP1	CASP5
Name		NLR family pyrin domain containing 1	caspase 5
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Canonical Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex	Cytoplasm Cytosol Protein-containing Complex NLRP1 Inflammasome Complex
	Molecular Function	Nucleotide Binding Double-stranded DNA Binding Double-stranded RNA Binding Endopeptidase Activity Protein Binding ATP Binding Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Protein Domain Specific Binding Signaling Adaptor Activity Pattern Recognition Receptor Activity Cysteine-type Endopeptidase Activator Activity Molecular Condensate Scaffold Activity	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Immune System Process Proteolysis Apoptotic Process Inflammatory Response Signal Transduction Programmed Cell Death Response To Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Homooligomerization Neuron Apoptotic Process Protein Maturation Defense Response To Virus Pyroptotic Inflammatory Response Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway Self Proteolysis Antiviral Innate Immune Response Canonical Inflammasome Complex Assembly Positive Regulation Of Pyroptotic Inflammatory Response Pyroptotic Cell Death NLRP1 Inflammasome Complex Assembly	Proteolysis Apoptotic Process Substantia Nigra Development Interleukin-18-mediated Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Inflammatory Response Protein Maturation Cellular Response To Mechanical Stimulus
Pathways		The NLRP1 inflammasome	Pyroptosis CASP5 inflammasome assembly CASP5-mediated substrate cleavage
GWAS		Migraine ( 27322543 )	No GWAS studies recorded
Interacting Genes		10 interacting genes: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 MAPK14 NOD1 PYCARD	3 interacting genes: MAX NLRP1 PPHLN1
Entrez ID		22861	838
HPRD ID		07364	04048
Ensembl ID		ENSG00000091592	ENSG00000137757
Uniprot IDs		Q9C000	P51878
PDB IDs		1PN5 3KAT 4IFP 4IM6 5Y3S 6K7V 6X6C 6XKK 7WGE 8ZGD	Not available
GO Terms Enriched among Interactors		Cell Death Apoptotic Process Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Regulation Of Programmed Cell Death NLRP1 Inflammasome Complex Cellular Response To Stress Apoptotic Signaling Pathway Intracellular Signal Transduction Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Regulation Of Neuron Apoptotic Process Programmed Cell Death Involved In Cell Development Neuron Apoptotic Process Identical Protein Binding Protein Maturation Cysteine-type Peptidase Activity Signal Transduction Apoptosome Dendritic Cell Apoptotic Process AIM2 Inflammasome Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Apoptotic Signaling Pathway Protein-containing Complex Response To Virus Response To External Biotic Stimulus DNA Damage Response Pyroptotic Inflammatory Response Response To Stress Epithelial Cell Apoptotic Process Leukocyte Apoptotic Process Response To Mechanical Stimulus BH3 Domain Binding Positive Regulation Of Interleukin-1 Beta Production Response To Cytokine Positive Regulation Of Neuron Apoptotic Process Response To Peptide Osmosensory Signaling Pathway Positive Regulation Of Interleukin-1 Production NLRP3 Inflammasome Complex Cellular Response To Mechanical Stimulus Cytosol Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Response To Other Organism Cysteine-type Endopeptidase Activator Activity	Myc-Max Complex Mad-Max Complex Protein Localization To Heterochromatin Positive Regulation Of Pyroptotic Inflammatory Response Self Proteolysis NLRP3 Inflammasome Complex NLRP1 Inflammasome Complex Cysteine-type Endopeptidase Activator Activity NLRP1 Inflammasome Complex Assembly Cellular Response To UV-B Canonical Inflammasome Complex Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Pyroptotic Cell Death