DOLK and EDA

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid, two hybrid)

		DOLK	EDA
Name		dolichol kinase	ectodysplasin A
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function	Dolichol Kinase Activity Protein Binding Kinase Activity Transferase Activity	Signaling Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Death Receptor Agonist Activity
	Biological Process	Protein N-linked Glycosylation Dolichyl Diphosphate Biosynthetic Process Lipid Metabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process	Hair Follicle Development Immune Response Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cell Differentiation Odontogenesis Of Dentin-containing Tooth Odontogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Skin Development Canonical Wnt Signaling Pathway Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Synthesis of dolichyl-phosphate Defective DOLK causes DOLK-CDG	TNFs bind their physiological receptors
Diseases		Congenital disorders of glycosylation (CDG) type I	Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia
GWAS		No GWAS studies recorded	Male-pattern baldness ( 30573740 ) Metabolite levels ( 23823483 ) Monobrow ( 27182965 ) Primary tooth development (number of teeth) ( 20195514 23704328 ) Primary tooth development (time to first tooth eruption) ( 20195514 23704328 ) Tooth agenesis (maxillary lateral incisors) ( 29364747 )
Interacting Genes		21 interacting genes: APPBP2 CD79A CHODL CREB3 CREB3L1 EDA FAM209A FNDC9 GALNT8 GJA8 GPX8 KCNA1 KCNA10 KCNA3 KCNA6 SLC7A6 SYNPR TMEM45B TMEM80 UBQLN1 VSIR	23 interacting genes: ATP6V0C CTXN3 CYB561 DOLK EDA2R EDAR EMP1 EMP3 FURIN GIMAP5 LEPROTL1 LPAR3 MAL MS4A13 OSTC OSTCP1 PLN PMP22 SEC22A SLC38A7 TMEM42 TMEM50B TMEM60
Entrez ID		22845	1896
HPRD ID		15525	02347
Ensembl ID		ENSG00000175283	ENSG00000158813
Uniprot IDs		A0A0S2Z597 Q9UPQ8	A0A0U5J797 Q92838
PDB IDs		Not available	1RJ7 1RJ8 7X9G
GO Terms Enriched among Interactors		Membrane Delayed Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Action Potential Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Protein Homooligomerization Regulation Of Response To Endoplasmic Reticulum Stress Protein Complex Oligomerization Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway L-lysine:L-arginine Antiporter Activity Positive Regulation Of Deacetylase Activity Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Collagen Catabolic Process Regulation Of Collagen Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway	Bleb Assembly Membrane Lysosomal Membrane Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Epidermis Development Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Dolichol Kinase Activity L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity