FHL3 and QRICH1

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (two hybrid, two hybrid, affinity chromatography technology)

		FHL3	QRICH1
Name		four and a half LIM domains 3	glutamine rich 1
Structure			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Focal Adhesion Z Disc	Nucleus Cytoplasm Plasma Membrane Membrane
	Molecular Function	Transcription Coregulator Activity Actin Binding Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Protein Binding
	Biological Process	Muscle Organ Development Actin Cytoskeleton Organization	Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Integrated Stress Response Signaling
GWAS		Coronary artery disease ( 29212778 33020668 ) Pulse pressure ( 30578418 )	Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Coronary artery disease ( 29212778 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) General factor of neuroticism ( 30867560 ) Inflammatory bowel disease ( 28067908 ) Refractive error ( 32231278 ) Resting heart rate ( 27798624 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		181 interacting genes: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP ANKHD1 ARHGEF10 ARID5A ASCL4 BARX2 C1orf94 CASS4 CBX8 CCDC198 CCND3 CDC25B CDC42EP1 CDKN1A CDKN2D CHEK2 CIMAP1B CLCN2 CNNM3 CNOT7 CORO1A CREB5 CRIP3 CRYBA2 CSF1 CTBP2 CYSRT1 DCDC2B DLGAP4 DMRT3 DUX4L9 E2F8 EFCAB12 EIF4EBP2 EPHA10 EPM2AIP1 ERBB3 EXOSC1 EXOSC5 FADS6 FAM110A FAM222B FAM90A1 FBXL18 FHL2 FOS FOSL2 FOXN4 GARIN6 GATA1 GATA2 GCM2 GUCD1 HAPLN2 HIPK1 HOXA1 HSF2BP HYAL2 HYCC1 IHO1 IKZF3 ITGA7 ITGB5 KANK2 KIDINS220 KIRREL2 KLF12 KLF3 KLF8 KPRP KRTAP12-1 KRTAP12-2 KTI12 LASP1 LATS2 LHB LMO2 LMO4 LNX1 LNX2 MAPK1 MED15 MMP14 MORF4L1 MPZL1 MRM3 MRPL27 MRRF MSRB3 MTA1 MTUS2 MYBPC1 MYBPHL MYCBP2 MYOZ3 MYPOP MZF1 NDUFAB1 NFKBIB NPRL3 P4HA2 PAK5 PATL1 PHC2 PHF21A PIAS1 PIERCE1 PKP2 PLEKHF2 PLEKHG4B POLR1H PPIG PRR35 PRR5L PTPN6 QKI QRICH1 RAB40B RAD21 RASL12 RBM42 RFX3 RFX6 RHEBL1 RSPH14 RYBP SAP30BP SAXO1 SAXO4 SBF2 SDCBP SH3GLB2 SHE SLAIN1 SLC25A46 SLC44A3 SLU7 SMAD2 SMAD3 SMAD4 SNRPB SNRPC SNRPG SPATA8 SPMAP2 SREBF2 SRF SRGN SUPT5H TBC1D22B THAP7 TLE5 TMEM108 TMEM14B TMSB4X TMX3 TRAF3IP2 TRIM27 TRIP6 TRO TSGA10IP TTLL10 TUBA3E TYK2 TYMSOS UBE2I UBE2Q1 VWC2L WDR25 WNK1 YPEL3 ZCCHC14 ZFP36 ZNF417 ZNF512B ZNF587	55 interacting genes: ACTL9 ACTMAP ARID5A ATF7IP ATXN1 BICRAL CEACAM6 CIMIP2B CRX CRYAA CYSRT1 DNAAF6 DSCR9 FHL2 FHL3 FHL5 GMCL1 HIVEP1 HSFY1 HSPB8 KHDC4 KLHDC7B LASP1 LBX1 LHX3 LHX4 LMO3 LMO4 MEOX1 MYH7B NFIX NFYA NLK PAX6 PIERCE2 POGZ POU6F2 PRKAR1B PUF60 RBM17 SELENOV SEPHS1 SIAH1 SMAP1 SP2 SRARP TEKT5 TOX4 TRAF1 TRAF2 USP54 YPEL3 ZDHHC17 ZMAT1 ZYX
Entrez ID		2275	54870
HPRD ID		09101	13372
Ensembl ID		ENSG00000183386	ENSG00000198218
Uniprot IDs		Q13643 Q96C98	A1L3Z9 Q2TAL8
PDB IDs		1WYH 2CUQ 2EHE	Not available
GO Terms Enriched among Interactors		Protein Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Ventral Spinal Cord Interneuron Differentiation Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Chromatin Binding Positive Regulation Of Biosynthetic Process Regulation Of MiRNA Metabolic Process Transcription Coregulator Binding DNA-binding Transcription Factor Activity Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Phosphatase Binding Positive Regulation Of Macromolecule Metabolic Process Cell Population Proliferation Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Identical Protein Binding SMAD Protein Complex Sequence-specific Double-stranded DNA Binding Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Positive Regulation Of MiRNA Metabolic Process Heteromeric SMAD Protein Complex Myelination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axon Ensheathment	Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Medial Motor Column Neuron Differentiation Cell Differentiation In Spinal Cord Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of RNA Metabolic Process Motor Neuron Axon Guidance Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Transcription Regulator Complex DNA Binding Spinal Cord Motor Neuron Cell Fate Specification DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process Thioesterase Binding Spinal Cord Association Neuron Differentiation HMG Box Domain Binding