FGF9 and FGFR3

Number of citations: 0 (PubMedID 10574949)
Data Source: BioGRID (pull down), HPRD (in vivo, in vitro)

		FGF9	FGFR3
Name		fibroblast growth factor 9	fibroblast growth factor receptor 3
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Focal Adhesion Cell Surface Membrane Transport Vesicle Cytoplasmic Vesicle Receptor Complex
	Molecular Function	Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparin Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Fibroblast Growth Factor Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Osteoblast Differentiation Eye Development Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Protein Import Into Nucleus Signal Transduction Smoothened Signaling Pathway Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Mesenchymal Cell Proliferation Positive Regulation Of Gene Expression Wnt Signaling Pathway Substantia Nigra Development Neurogenesis Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Male Sex Determination Lung Development Embryonic Limb Morphogenesis Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Inner Ear Morphogenesis Positive Regulation Of MAPK Cascade Positive Regulation Of Smoothened Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Timing Of Cell Differentiation Embryonic Digestive Tract Development Embryonic Skeletal System Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Sertoli Cell Proliferation Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Lung-associated Mesenchyme Development Stem Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Positive Regulation Of Stem Cell Proliferation	MAPK Cascade Skeletal System Development Ossification Endochondral Ossification Chondrocyte Differentiation Endochondral Bone Growth Apoptotic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Bone Mineralization Chondrocyte Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Negative Regulation Of Developmental Growth Cartilage Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Transcriptional regulation of testis differentiation	Signaling by activated point mutants of FGFR3 t(4;14) translocations of FGFR3 Signaling by FGFR3 in disease Signaling by FGFR3 fusions in cancer
Drugs		None	XL999 Pazopanib Ponatinib Lenvatinib Nintedanib Infigratinib Fostamatinib Erdafitinib Pemigatinib Futibatinib Selpercatinib
Diseases		None	CATSHL syndrome Multiple myeloma FGFR3-related short limb skeletal dysplasias, including: Achondroplasia; Hypochondroplasia; Thanatophoric dysplasia, type 1; Thanatophoric dysplasia, type 2; Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN) Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome Bladder cancer
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Aspartate aminotransferase levels ( 33547301 ) Asthma (childhood onset) ( 27611488 ) Central corneal thickness ( 29760442 ) Chin dimples ( 27182965 ) Corneal structure ( 23291589 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945 ) Systolic blood pressure ( 30224653 ) Type 2 diabetes ( 32499647 )	Bladder cancer ( 20972438 24163127 ) Blood protein levels ( 30072576 ) Hip circumference adjusted for BMI ( 34021172 ) Metabolite levels ( 23823483 ) Urinary bladder cancer ( 20348956 )
Interacting Genes		4 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4	43 interacting genes: ANOS1 ARAP1 ATF3 BORA C6orf47 CCDC17 CEP126 CHGB CTSK EPHA4 ERBB2 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GPSM3 GRB2 GTF3C1 HBZ HNRNPL KRT8 NDUFS6 NECTIN1 POLA2 PTK2B RADIL RNF130 RPL8 RPS6KA3 SH2B1 SLC25A6 SMG7 SRPK2 STAT1 STAT3
Entrez ID		2254	2261
HPRD ID		02951	00624
Ensembl ID		ENSG00000102678	ENSG00000068078
Uniprot IDs		P31371	F8W9L4 P22607 Q0IJ44 X5D2G8
PDB IDs		1G82 1IHK 5W59	1RY7 2LZL 4K33 6LVM 6PNX 7DHL 7YSU 8UDT 8UDU 8UDV 9CD7
GO Terms Enriched among Interactors		Fibroblast Growth Factor Receptor Activity Fibroblast Growth Factor Binding Positive Regulation Of Phospholipase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Lipase Activity Protein Tyrosine Kinase Activity Receptor Complex Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Catalytic Activity Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Peptidyl-tyrosine Phosphorylation Forebrain Neuroblast Division Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Biomineral Tissue Development Forebrain Ventricular Zone Progenitor Cell Division Protein Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Lung-associated Mesenchyme Development Protein Autophosphorylation Endochondral Bone Growth Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Branching Involved In Salivary Gland Morphogenesis Heparin Binding Positive Regulation Of ERK1 And ERK2 Cascade Bone Growth Positive Regulation Of Cell Population Proliferation Mesenchymal Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Gland Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction Midbrain Development Regulation Of Developmental Growth Regulation Of Mesenchymal Cell Proliferation Bone Morphogenesis Positive Regulation Of Heart Growth Protein Phosphorylation Response To Fibroblast Growth Factor Ureteric Bud Development Regulation Of Cardiac Muscle Cell Proliferation ATP Binding Phosphorylation	Fibroblast Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neurogenesis Fibroblast Growth Factor Receptor Binding Growth Factor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Division Type 2 Fibroblast Growth Factor Receptor Binding Type 1 Fibroblast Growth Factor Receptor Binding Regulation Of Cell Division Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Cell Differentiation Positive Regulation Of Cell Communication Cell Surface Receptor Signaling Pathway Signal Transduction Lung Development Mesenchymal Cell Proliferation Cellular Developmental Process Positive Regulation Of ERK1 And ERK2 Cascade Extracellular Space Regulation Of Signal Transduction Stem Cell Proliferation Positive Regulation Of MAP Kinase Activity Cell Population Proliferation Heparin Binding Negative Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Stem Cell Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Corticotropin Hormone Secreting Cell Differentiation Angiogenesis Positive Regulation Of Cell Migration Regulation Of Anatomical Structure Morphogenesis Regulation Of Chemotaxis