FDPS and EIF4ENIF1

Number of citations: 32 (PubMedID 19060904)
Data Source: BioGRID (two hybrid)

		FDPS	EIF4ENIF1
Name		farnesyl diphosphate synthase	eukaryotic translation initiation factor 4E nuclear import factor 1
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrial Matrix Peroxisome Cytosol	P-body Nucleus Cytoplasm Cytosol Membrane PML Body Nuclear Speck Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	RNA Binding Dimethylallyltranstransferase Activity (2E,6E)-farnesyl Diphosphate Synthase Activity Prenyltransferase Activity Protein Binding Transferase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Metal Ion Binding	RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Protein Binding Kinase Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Sterol Biosynthetic Process Geranyl Diphosphate Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process	Translation Regulation Of Translation Protein Import Into Nucleus Protein Transport Negative Regulation Of Translation Stem Cell Population Maintenance Neuron Differentiation Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Neuron Differentiation MRNA Stabilization Nuclear Export Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	None
Drugs		Pamidronic acid Zoledronic acid Alendronic acid Ibandronate Risedronic acid Dimethylallyl Diphosphate Isopentyl Pyrophosphate Geranyl Diphosphate ISOPENTENYL PYROPHOSPHATE Incadronic acid Minodronic acid Farnesyl diphosphate Geranylgeranyl diphosphate	None
GWAS		Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Glycated hemoglobin levels ( 34059833 ) Inflammatory bowel disease ( 28067908 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Age-related hearing impairment ( 24939585 ) Fish- and plant-related diet ( 32066663 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 )
Interacting Genes		9 interacting genes: ABHD16A ATXN1 CEBPA CREB3 EIF4ENIF1 FGFR1 RNF19B SLC30A2 SSMEM1	92 interacting genes: ALG13 ANKHD1 ANXA2 ATP5F1B ATXN1 BAG4 BCAS2 BYSL CDK6 CFAP206 CLASP1 CLK3 CPSF7 CTNNA1 CUL1 DAPK1 DDX1 DDX11 DDX28 DEF6 DHX37 DHX57 DST DTX2 EEF1G EFHC1 EHMT2 EIF3E EIF4E EIF4E2 ELAVL3 EXOSC7 FANCL FDPS FTSJ3 GOLGA4 HDGF HNRNPF HNRNPLL HOOK3 HSPA1A KPNA2 KRT19 KRT31 L3MBTL2 LLPH LMNA LUC7L MGAT5B MYO10 NOP9 NXF3 OIP5 PKP2 PNKP POLR2A PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAE1 RBBP6 RBFOX2 RBM22 RNF10 RPL15 RPL19 RPL26 RPL31 RPRD1B RPS21 RPS6 RPS7 SF3B3 SMAD3 SNRNP40 SNRPN SPAG5 SRBD1 SRSF8 SUPV3L1 TCHP TRAK2 TTC19 TUBA1A TXLNA USP2 WBP4 WTAP XRCC6
Entrez ID		2224	56478
HPRD ID		00606	10456
Ensembl ID		ENSG00000160752	ENSG00000184708
Uniprot IDs		A0A087X090 P14324	Q9NRA8
PDB IDs		1YQ7 1YV5 1ZW5 2F7M 2F89 2F8C 2F8Z 2F92 2F94 2F9K 2OPM 2OPN 2QIS 2RAH 2VF6 3B7L 3CP6 3N1V 3N1W 3N3L 3N45 3N46 3N49 3N5H 3N5J 3N6K 3RYE 3S4J 4DEM 4GA3 4H5C 4H5D 4H5E 4JVJ 4KFA 4KPD 4KPJ 4KQ5 4KQS 4KQU 4L2X 4LFV 4LPG 4LPH 4N1Z 4N9U 4NFI 4NFJ 4NFK 4NG6 4NKE 4NKF 4NUA 4OGU 4P0V 4P0W 4P0X 4PVX 4PVY 4Q23 4QPF 4QXS 4RXA 4XQR 4XQS 4XQT 5CG5 5CG6 5DGM 5DGN 5DGS 5DIQ 5DJP 5DJR 5DJV 5JA0 5JUZ 5JV0 5JV1 5JV2 5KSX 5YGI 6N7Y 6N7Z 6N82 6N83 6OAG 6OAH	5ANR 6F9W 6X2R
GO Terms Enriched among Interactors		Positive Regulation Of Osteoblast Differentiation Stem Cell Proliferation Regulation Of Stem Cell Proliferation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Macromolecule Biosynthetic Process Chemical Homeostasis Positive Regulation Of Cell Differentiation Response To Vitamin B2 C/EBP Complex Integrated Stress Response Signaling Regulation Of Cell Differentiation Embryonic Limb Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Mitotic Cell Cycle DNA Replication Regulation Of Lateral Mesodermal Cell Fate Specification Positive Regulation Of Parathyroid Hormone Secretion Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Positive Regulation Of Deacetylase Activity Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA DNA-templated Transcription Kinase Binding Chromatin Binding Lung Development CHOP-C/EBP Complex White Fat Cell Proliferation Memory Identical Protein Binding Limb Morphogenesis Sequestering Of TGFbeta In Extracellular Matrix Receptor-receptor Interaction Ventricular Zone Neuroblast Division Regulation Of Mitotic Cell Cycle DNA Replication Diphosphate Metabolic Process Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Orbitofrontal Cortex Development Negative Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Phospholipase Activity POZ Domain Binding Zinc Ion Import Into Lysosome Zinc Export Across Plasma Membrane Nuclear Export Nuclear Matrix RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex	RNA Binding RNA Processing MRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process Nucleic Acid Binding Nucleoplasm Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Processing Regulation Of RNA Splicing Nucleus Nucleolus Cytosolic Ribosome Ribonucleoprotein Complex Cytoplasm Translation RNA Splicing Structural Constituent Of Ribosome RRNA Processing Nuclear Speck Cytoplasmic Translation Helicase Activity RRNA Metabolic Process Catalytic Step 2 Spliceosome Centrosome MRNA Splicing, Via Spliceosome Protein Binding RNA Splicing, Via Transesterification Reactions Macromolecule Biosynthetic Process Cytoskeleton Preribosome, Small Subunit Precursor Ribonucleoprotein Complex Biogenesis RNA Helicase Activity Prp19 Complex Spliceosomal Complex MRNA Binding Ribosome Positive Regulation Of RNA Splicing RNA 3'-end Processing Regulation Of Neurogenesis Microtubule Cytoskeleton Organization MRNA Cap Binding Ubiquitin Protein Ligase Binding Cytosolic Large Ribosomal Subunit Microtubule Plus-end Microtubule Anchoring Chromosome Cytosol Structural Molecule Activity