JMJD1C and MT2A

Number of citations: 0 (PubMedID 23455924)
Data Source: BioGRID (two hybrid)

		JMJD1C	MT2A
Name		jumonji domain containing 1C	metallothionein 2A
Structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	Transcription Coregulator Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Chromatin DNA Binding Histone H3K9 Demethylase Activity Metal Ion Binding Nuclear Thyroid Hormone Receptor Binding Dioxygenase Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Blood Coagulation	Intracellular Copper Ion Homeostasis Intracellular Zinc Ion Homeostasis Detoxification Of Copper Ion Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion
Pathways		Factors involved in megakaryocyte development and platelet production	Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling
Drugs		None	Zinc Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
GWAS		Adult body size ( 32376654 ) Androgen levels ( 22936694 ) Apolipoprotein A1 levels ( 32203549 ) Arthritis (juvenile idiopathic) ( 22354554 ) Asthma ( 27611488 ) Asthma (childhood onset) ( 27611488 ) Basophil percentage of granulocytes ( 27863252 ) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809 ) Cognitive ability ( 29186694 ) Cognitive ability (MTAG) ( 29186694 ) CXCL5 levels ( 25147954 ) Cytokine levels ( 31679650 ) Cytokine network levels (multivariate analysis) ( 31679650 ) Educational attainment ( 25201988 ) Eosinophil percentage of white cells ( 32888494 ) Fasting plasma glucose ( 31170924 ) FEV1 ( 30804560 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 26561523 28107422 ) Gallstone disease ( 30504769 ) General cognitive ability ( 29844566 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) HDL cholesterol levels ( 32203549 ) High density lipoprotein cholesterol levels ( 31928498 ) High light scatter reticulocyte count ( 27863252 ) Household income (MTAG) ( 31844048 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Inflammatory biomarkers (multivariate analysis) ( 33110245 ) Insulin-related traits (multivariate analysis) ( 32002517 ) Intelligence (MTAG) ( 29326435 ) Liver enzyme levels ( 18940312 ) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lung function (FEV1) ( 30061609 ) Lung function (FEV1/FVC) ( 30061609 ) Lung function (FVC) ( 30804560 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Macular telangiectasia type 2 ( 33654266 ) Mean platelet volume ( 19820697 22139419 24026423 27863252 28031487 31194788 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolic syndrome ( 31589552 ) Metabolite levels ( 23823483 ) Monocyte percentage of white cells ( 27863252 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 32888494 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311 ) Platelet aggregation ( 20526338 29185836 ) Platelet count ( 22139419 22423221 23263863 24026423 26805783 27863252 32888494 ) Platelet distribution width ( 27863252 32888494 ) Plateletcrit ( 32888494 ) Prothrombin time ( 29403010 ) Schizophrenia ( 28991256 ) Serum alkaline phosphatase levels ( 29403010 31666285 33339817 ) Sex hormone-binding globulin levels ( 22829776 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Total bilirubin levels ( 29403010 ) Triglyceride levels ( 28334899 29403010 31928498 32154731 32203549 33339817 ) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 20686565 24097068 25961943 ) Type 2 diabetes ( 28406950 32499647 ) Urate levels ( 31578528 ) Vascular endothelial growth factor levels ( 26910538 27989323 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 ) Walking pace ( 33128006 ) White blood cell count ( 27863252 )	No GWAS studies recorded
Interacting Genes		16 interacting genes: AR ESR2 GADD45A KLHL20 MT2A MYOM2 NR3C1 NUDT21 PPARG PSMC1 RNF168 RNF8 RXRA SRPK2 THRB TK1	21 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PPDPF PRKD1 RCHY1 RIN3 SHBG SPINK7 TNS2 USP25 USP40
Entrez ID		221037	4502
HPRD ID		05141	08863
Ensembl ID		ENSG00000171988	ENSG00000125148
Uniprot IDs		B7ZLC8 Q15652	P02795
PDB IDs		2YPD 5FZO 9GDK	1MHU 2MHU
GO Terms Enriched among Interactors		Nuclear Receptor Activity Nuclear Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Estrogen Response Element Binding Negative Regulation Of DNA-templated Transcription Steroid Hormone Receptor Signaling Pathway Intracellular Signal Transduction Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nuclear Steroid Receptor Activity Retinoic Acid Receptor Signaling Pathway Zinc Ion Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Steroid Binding Nucleic Acid Metabolic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Chromatin Binding Nucleus DNA Binding Domain Binding Positive Regulation Of Lipoprotein Transport MRNA Transcription By RNA Polymerase II Regulation Of Thyroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Macromolecule Metabolic Process LBD Domain Binding Nucleobase-containing Compound Metabolic Process Positive Regulation Of MiRNA Transcription DNA-binding Transcription Factor Activity MRNA Transcription Enzyme Binding Chromatin Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Transcription By RNA Polymerase II Modification-dependent Protein Catabolic Process Monocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding MRNA Metabolic Process	Negative Regulation Of Endocytosis Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Negative Regulation Of Transport Regulation Of Cellular Component Size Positive Regulation Of Protein Localization To Nucleus Liver Development Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Cellular Response To Stress Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Localization Erythrocyte Apoptotic Process Positive Regulation Of Establishment Of Protein Localization Regulation Of Endocytosis Negative Regulation Of Receptor-mediated Endocytosis Argininosuccinate Synthase Activity Argininosuccinate Metabolic Process Regulation Of Intracellular Protein Transport Regulation Of Protein Export From Nucleus Response To Ionizing Radiation Negative Regulation Of MRNA 3'-end Processing Dihydroorotate Dehydrogenase Activity Dihydroorotate Dehydrogenase (quinone) Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Negative Regulation Of Mast Cell Chemotaxis