FABP1 and PPARA

Number of citations: 36 (PubMedID 11226238)
Data Source: HPRD (in vivo, two hybrid, in vitro)

		FABP1	PPARA
Name		fatty acid binding protein 1	peroxisome proliferator activated receptor alpha
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisomal Matrix Cytosol Extracellular Exosome	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Chromatin Binding Fatty Acid Binding Protein Binding Lipid Binding Antioxidant Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Lipid Binding Phosphatase Binding Protein Domain Specific Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Conjugating Enzyme Binding Signaling Receptor Activity Sequence-specific DNA Binding Protein-containing Complex Binding Metal Ion Binding NFAT Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding MDM2/MDM4 Family Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Fatty Acid Transport Cellular Response To Hydrogen Peroxide Cellular Response To Hypoxia Cellular Oxidant Detoxification Cellular Detoxification	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Gluconeogenesis Regulation Of DNA-templated Transcription Lipid Metabolic Process Fatty Acid Metabolic Process Heart Development Response To Nutrient Lactation Epidermis Development Cellular Response To Starvation Hormone-mediated Signaling Pathway Gene Expression Regulation Of Gene Expression Regulation Of Ketone Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Cholesterol Storage Regulation Of Fatty Acid Metabolic Process Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Appetite Response To Insulin Circadian Regulation Of Gene Expression Behavioral Response To Nicotine Peroxisome Proliferator Activated Receptor Signaling Pathway Wound Healing Lipoprotein Metabolic Process Regulation Of Circadian Rhythm Response To Ethanol Positive Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nitric Oxide Metabolic Process Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Lipid Biosynthetic Process Rhythmic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Enamel Mineralization Cellular Response To Fructose Stimulus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of MiRNA Transcription Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Transformation Of Host Cell By Virus Regulation Of Fatty Acid Transport Positive Regulation Of ATP Biosynthetic Process
Pathways		Triglyceride catabolism Heme degradation PPARA activates gene expression Regulation of lipid metabolism by PPARalpha Cytoprotection by HMOX1	BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha SUMOylation of intracellular receptors Cytoprotection by HMOX1 Heme signaling Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs		None	alpha-Linolenic acid Icosapent Troglitazone Valproic acid Indomethacin Rosiglitazone Fenoprofen Clofibrate Fenofibrate Ibuprofen Amiodarone Gemfibrozil Bezafibrate Prasterone N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide Flufenamic acid Resveratrol Phthalic Acid Lauric acid Stearic acid Doconexent Palmitic Acid Oleic Acid Caprylic acid Arachidonic Acid Reglitazar Elafibranor Cardarine Muraglitazar Ertiprotafib Ragaglitazar Tesaglitazar GW-590735 Indeglitazar Myristic acid Aleglitazar Clinofibrate Ciprofibrate Dexibuprofen Soybean oil Omega-3 fatty acids Myrrh Isoflavone Leukotriene B4 Fenofibric acid Fish oil
GWAS		Alanine aminotransferase levels ( 33547301 ) Blood protein levels ( 30072576 ) C-reactive protein levels ( 30388399 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver fibrosis in non-alcoholic fatty liver disease ( 31311600 ) Night sleep phenotypes ( 27126917 ) Serum alkaline phosphatase levels ( 33547301 )	Cholesterol, total ( 24097068 ) CTACK levels ( 27989323 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Impulsivity (motor) ( 30718321 ) LDL cholesterol ( 24097068 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Refractive error ( 32231278 ) Resting-state electroencephalogram vigilance ( 29703947 ) Triglyceride levels ( 32203549 ) Type 2 diabetes ( 31049640 ) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659 )
Interacting Genes		5 interacting genes: FLNA GRB2 PPARA PPARG SNTA1	70 interacting genes: AIP AKAP13 ANKRD11 AQP1 BCL2 CCDC179 CDC34 CDK3 CEP350 CHD9 CHIC2 COL8A1 CTNNA3 DAP3 DUT EP300 EXOSC4 FABP1 FAM90A1 FAM9B FBLN1 FOXA3 GADD45A GADD45B GADD45G GPANK1 HELZ2 HOXC8 HSP90AA1 KCTD7 KRTAP10-1 LAMTOR5 MAPK1 MAPK3 MECR MED1 MED24 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR1H2 NR1H3 NRBF2 NRIP1 PAQR3 PICK1 PIK3R3 POU1F1 PPARGC1A PPARGC1B PRKCA PRKCD PRMT1 PRMT8 RELA RXRA RXRG SDCBP SIRT1 STAC3 TNP1 TRIM55 TRIM63 UBE2I VWA5A VWC2L ZNF587 ZSCAN23
Entrez ID		2168	5465
HPRD ID		00612	01369
Ensembl ID		ENSG00000163586	ENSG00000186951
Uniprot IDs		P07148 Q05CP7 Q6FGL7	F1D8S4 Q07869
PDB IDs		2F73 2L67 2L68 2LKK 2PY1 3B2H 3B2I 3B2J 3B2K 3B2L 3STK 3STM 3STN 3VG2 3VG3 3VG4 3VG5 3VG6 3VG7 6DO6 6DO7 6DRG 6MP4 7DZE 7DZF 7DZG 7DZH 7DZI 7DZJ 7DZK 7DZL 7FXO 7FY8 7FYA 7G00 7G0W 7G1X	1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK 6KAX 6KAY 6KAZ 6KB0 6KB1 6KB2 6KB3 6KB4 6KB5 6KB6 6KB7 6KB8 6KB9 6KBA 6KXX 6KXY 6KYP 6L36 6L37 6L38 6L96 6LX4 6LX5 6LX6 6LX7 6LX8 6LX9 6LXA 6LXB 6LXC 7BPY 7BPZ 7BQ0 7BQ1 7BQ2 7BQ3 7BQ4 7C6Q 7E5F 7E5G 7E5H 7E5I 8HUK 8HUN 8HUQ 8RCE
GO Terms Enriched among Interactors		Negative Regulation Of Cholesterol Storage Negative Regulation Of Macrophage Derived Foam Cell Differentiation Peroxisome Proliferator Activated Receptor Signaling Pathway DNA-binding Transcription Factor Binding Negative Regulation Of Lipid Storage Negative Regulation Of MiRNA Transcription Regulation Of Membrane Repolarization Negative Regulation Of Defense Response Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Muscle Hypertrophy MRNA Transcription By RNA Polymerase II Regulation Of Lipid Storage Regulation Of Biological Quality Nuclear Receptor Activity MRNA Transcription Regulation Of Multicellular Organismal Process Regulation Of Cardiac Muscle Hypertrophy Regulation Of MiRNA Transcription Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of MiRNA Metabolic Process Positive Regulation Of Transformation Of Host Cell By Virus Regulation Of Transport Negative Regulation Of Innate Immune Response Regulation Of System Process Regulation Of Fatty Acid Metabolic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Circadian Rhythm Transmembrane Transporter Binding Regulation Of Reactive Oxygen Species Metabolic Process Grb2-EGFR Complex Regulation Of Ketone Metabolic Process Regulation Of Lipid Transport RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Positive Regulation Of Adiponectin Secretion Positive Regulation Of Lipid Metabolic Process Hormone-mediated Signaling Pathway Fc-gamma Receptor I Complex Binding Regulation Of Intracellular Signal Transduction Tubulin Deacetylation Myb Complex Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Small Molecule Metabolic Process Regulation Of Transformation Of Host Cell By Virus Response To Nutrient Positive Regulation Of Supramolecular Fiber Organization	Nuclear Receptor Binding Nucleoplasm Nuclear Receptor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Nucleus Transcription Coactivator Activity Intracellular Receptor Signaling Pathway Transcription Coregulator Activity Intracellular Signal Transduction Hormone-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process MRNA Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Lipid Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II MRNA Transcription Response To Hormone Chromatin Response To Steroid Hormone Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nuclear Retinoic Acid Receptor Binding Response To Nutrient Levels Regulation Of Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Retinoid X Receptor Binding Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Cellular Response To Nutrient Levels Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cholesterol Efflux Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Chromatin DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Primary Metabolic Process Nucleobase-containing Compound Biosynthetic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Transcription By RNA Polymerase II Response To Starvation