EPHB4 and SDC3

Number of citations: 0 (PubMedID 9388509)
Data Source: HPRD (in vitro)

		EPHB4	SDC3
Name		EPH receptor B4	syndecan 3
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Membrane Receptor Complex Extracellular Exosome	Golgi Lumen Plasma Membrane Cell Surface Membrane Extracellular Matrix Lysosomal Lumen Microspike
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Protein Binding Identical Protein Binding
	Biological Process	Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Heart Morphogenesis Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway	Cell Migration
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs		Dasatinib N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE 3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDE N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE 3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE Tesevatinib Fostamatinib	None
GWAS		Bipolar disorder ( 31043756 ) Blond vs. brown/black hair color ( 30531825 ) Mean corpuscular hemoglobin ( 27863252 ) Mean corpuscular volume ( 27863252 ) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020 ) Platelet distribution width ( 32888494 ) Resting heart rate ( 27798624 ) Takayasu arteritis ( 33308445 )	Loneliness ( 27629369 ) Systolic blood pressure ( 34074324 )
Interacting Genes		7 interacting genes: APP DTX3 EFNB2 FBXO7 GRIN1 SDC3 VCP	32 interacting genes: AGR2 CASK CMTM7 COL5A1 CSK CTTN CUX1 EPHB4 FGF2 FYN ITGB4 KCNJ2 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP9-2 LCE3D MDK PLN PTN SLC35A1 SMIM1 TMEM14C TMEM218 TUBA1A TUBB TUBB2A
Entrez ID		2050	9672
HPRD ID		02481	01719
Ensembl ID		ENSG00000196411	ENSG00000162512
Uniprot IDs		P54760 Q541P7 Q96L35	O75056
PDB IDs		2BBA 2E7H 2HLE 2QKQ 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD 2YN8 3ZEW 4AW5 4BB4 6FNI 6FNJ 6FNK 6FNL 6FNM	Not available
GO Terms Enriched among Interactors		Acetylcholine Receptor Activator Activity Amyloid-beta Complex Regulation Of Cellular Component Organization Regulation Of Neuronal Synaptic Plasticity Glutamate Receptor Signaling Pathway Regulation Of ATP Metabolic Process Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Synaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Response To Light Stimulus Regulation Of Cell Activation Visual Behavior Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Locomotion Perinuclear Region Of Cytoplasm Regulation Of Biological Quality Amylin Binding Response To Amyloid-beta Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of ATP Metabolic Process Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Cellular Response To Amyloid-beta Cell Adhesion Protein-containing Complex Lipoprotein Particle Extracellular Matrix Organization Regulation Of Receptor Internalization Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Import Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Extracellular Structure Organization Identical Protein Binding Negative Regulation Of Phosphate Transmembrane Transport Positive Regulation Of Wound Healing Establishment Of Endothelial Blood-brain Barrier Positive Regulation Of Aorta Morphogenesis Response To Glycine Propylene Metabolic Process Male Germ-line Sex Determination Flavin Adenine Dinucleotide Catabolic Process VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination EMILIN Complex	Intermediate Filament Keratin Filament Response To Mechanical Stimulus Cell Motility Cell Migration Positive Regulation Of Blood Vessel Branching Regulation Of Blood Vessel Branching Regulation Of Calcium Ion Import Leukocyte Chemotaxis Involved In Inflammatory Response Integrin Binding Cell Projection Morphogenesis Positive Regulation Of Chemotaxis Learning Or Memory Chondroitin Sulfate Binding Positive Regulation Of Hepatocyte Proliferation Dendritic Spine Maintenance Estrous Cycle Heparin Binding Anatomical Structure Morphogenesis Learning Relaxation Of Cardiac Muscle Cognition Regulation Of Response To Wounding Regulation Of Hepatocyte Proliferation Basement Membrane Proline-rich Region Binding Regulation Of Chemotaxis Positive Regulation Of Cell Division Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Vascular Endothelial Cell Proliferation Response To L-glutamate Relaxation Of Muscle Positive Regulation Of Oligodendrocyte Differentiation Cerebral Cortex Development Response To Auditory Stimulus Ovulation Cycle Leukocyte Migration Involved In Inflammatory Response Neuron Projection Arborization Positive Regulation Of Neurogenesis Positive Regulation Of Stem Cell Differentiation Schaffer Collateral - CA1 Synapse Structural Constituent Of Cytoskeleton Identical Protein Binding Cell Migration Involved In Sprouting Angiogenesis Glial Cell Differentiation Calcium Ion Transport Dentate Gyrus Development Integrin Biosynthetic Process Developmental Process Protein Tyrosine Kinase Activity